Article
Urology & Nephrology
Klaus Eredics, Theresa Luef, Stephan Madersbacher
Summary: This study retrospectively analyzed nonagenarians admitted to the urological ward, with the most common indications for admission being macrohematuria, bladder dysfunction, and urinary tract infection. The average age of patients was 92 years, with an in-house mortality rate of 9% and a 12 months mortality rate of 45%.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Oncology
Sofia Halin Bergstrom, Stina Rudolfsson, Marie Lundholm, Andreas Josefsson, Pernilla Wikstrom, Anders Bergh
Summary: The presence of high-grade tumors can increase the size and proliferation rate of low-grade tumors in experimental models and patient samples, as well as alter the surrounding microenvironment by increasing blood vessel density and macrophage density.
JOURNAL OF PATHOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Genaro Castro-Vazquez
Summary: Cancer has the highest mortality and morbidity rates, and kills more men than women in Japan. Culturally and medically constructed as a 'lifestyle-related disease', prostate cancer incidence is directly proportional to the 'Westernisation of eating habits', and societal ageing. Nevertheless, campaigns to advocate routine testing for prostate cancer remain non-existent.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Multidisciplinary Sciences
Sebnem Ece Eksi, Alex Chitsazan, Zeynep Sayar, George Thomas, Andrew J. Fields, Ryan P. Kopp, Paul T. Spellman, Andrew C. Adey
Summary: High tumor heterogeneity makes it difficult to identify molecular subtypes in prostate cancer. Here, the authors integrate single-cell chromatin accessibility data with multiplex imaging to reveal distinct chromatin features and transcription factor binding signatures in high- and low-grade prostate tumors.
NATURE COMMUNICATIONS
(2021)
Review
Gastroenterology & Hepatology
Shankar Kumar, Richard Pollok, David Goldsmith
Summary: Renal and urinary tract complications related to inflammatory bowel disease (IBD) have been neglected in the literature, but are important. Prompt diagnosis and treatment of these manifestations and complications require a high index of suspicion, while optimal screening and monitoring methods for renal function in IBD patients are still unclear. Urolithiasis is the most common manifestation, while penetrating Crohn's disease involving the genitourinary system as an extraintestinal complication is rare but associated with significant morbidity. Some biologic agents used to treat IBD have been implicated in progressive renal impairment, although differentiating between drug-related side effects and deteriorating kidney function due to other manifestations can be challenging. The most common findings on renal biopsy of IBD patients with renal injury are tubulointerstitial nephritis and IgA nephropathy, with the former also associated with drug-induced nephrotoxicity related to IBD medication. Amyloidosis, though rare, must be diagnosed early to reduce the risk of progression to renal failure. Considering the potential severity and implications of acute or chronic loss of renal function, prompt diagnosis and treatment of these manifestations and complications are crucial.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Qiang Song, Hao Yu, Jie Han, Jiancheng Lv, Qiang Lv, Haiwei Yang
Summary: Exosomes are extracellular vesicles that play various biological functions through proteins, nucleic acids, lipids, and metabolites. They have been found to have important roles in urological diseases and can be used for the diagnosis, treatment, and monitoring of these diseases.
Editorial Material
Urology & Nephrology
Jabril R. Johnson, Rick A. Kittles
Summary: There is a significant disparity in prostate cancer incidence and mortality between men of West African ancestry and men of European ancestry. Identifying different tumor genetic markers and immunomodulating signals in patients with diverse genetic backgrounds may help reduce the disparities in prostate cancer prognosis, treatment outcomes, and mortality in high-risk racial groups.
NATURE REVIEWS UROLOGY
(2022)
Review
Medicine, General & Internal
Vasile Simon, Sorin Marian Dudea, Nicolae Crisan, Vasile Dan Stanca, Marina Dudea-Simon, Iulia Andras, Zoltan Attila Mihaly, Ioan Coman
Summary: Elastography has diverse applications in the day-to-day clinical practice of urology, involving multiple organs and pathologies. However, further studies are needed due to a lack of standardization in methodology and equipment.
Article
Urology & Nephrology
Aaron Brant, Riccardo Campi, Diego M. Carrion, Francesco Esperto, Christina Sze, Jeffrey P. Johnson, Jim C. Hu, Leonardo D. Borregales
Summary: The study assesses the exposure of urology trainees to transperineal prostate biopsy (TP-Bx) and their intention to use TP-Bx in practice. Less than half of the surveyed trainees reported exposure to TP-Bx, with significant differences among countries. The study suggests that greater experience with TP-Bx during training is associated with a higher intention to perform TP-Bx in practice. The authors recommend setting a minimum requirement for TP-Bx cases during urological training to increase trainees' familiarity and adoption of this approach.
Review
Urology & Nephrology
Arjun Nathan, Boris Gershman, Henk Van der Poel, Prasanna Sooriakumaran, Derya Tilki
Summary: Prostate cancer poses a significant challenge for healthcare centers worldwide, leading to the implementation of centralization of services in the UK, Europe, and parts of the USA. The centralization has shown positive effects in improving patient outcomes, streamlining resource utilization, and reducing costs, but has also brought about negative impacts that need to be carefully addressed.
EUROPEAN UROLOGY FOCUS
(2021)
Article
Urology & Nephrology
Sutchin R. Patel, David A. Bloom, Anthony A. Caldamone
Summary: This study explores and documents the life and urologic contributions of Dr. Frank B. Bicknell through his publications, archived documents, and descriptions from colleagues. The results show that Dr. Frank B. Bicknell was an early leader in pediatric urology and urologic history, playing a significant role in the establishment of The Society of Pediatric Urology and the AUA History Forum.
Article
Urology & Nephrology
James Nie, Walter Hsiang, Victoria Marks, Folawiyo Laditi, Adarsh Varghese, Waez Umer, Afash Haleem, David Mothy, Hannah Wang, Riya Patel, William Pan, Rishi Shah, Sophia Khan, Rohan Singh, Vishnukamal Golla, Jaime Cavallo, Benjamin N. Breyer, Michael S. Leapman
Summary: This study investigates the appointment access for Medicaid-insured patients seeking care at urology practices affiliated with private equity firms. The findings suggest that private equity-affiliated practices have lower Medicaid acceptance and more pronounced access disparities than non-private equity affiliated practices.
Article
Psychology, Social
Mehmet Serkan Ozkent, Muzaffer Tansel Kilinc, Mustafa Bilal Hamarat, Burak Yilmaz, Yunus Emre Goger, Yasemin Ozkent, Mehmet Mesut Piskin
Summary: This study evaluated the levels of cyberchondria in patients attending the urology outpatient clinic, and found a correlation between cyberchondria severity and health anxiety. Male patients and uro-oncological diseases showed a higher association with cyberchondria severity and health anxiety. Additionally, there was a positive correlation between cyberchondria severity and health anxiety.
CYBERPSYCHOLOGY BEHAVIOR AND SOCIAL NETWORKING
(2023)
Article
Urology & Nephrology
Floriane Michel, Fabiana Cancrini, Geraldine Cancel-Tassin, Xavier Game, Eric Huyghe, Aurelien Rock, Gregoire Leon, Audrey Uzan, Francois-Regis Desfemmes, Benoit Peyronnet, Jeremy Fallot, Priscilla Leon, Emmanuel Rolland, Marie-Aimee Perrouin-Verbe, Jacques Wodey, Gregoire Capon, Gilles Karsenty, Morgan Roupret, Olivier Cussenot, Hussa Alshehhi, Eva Comperat, Veronique Phe
Summary: This study aimed to investigate the expression of cell markers in neuro-urological patients with bladder cancer (NBC) and its correlation with carcinogenesis. The results showed that markers of basal differentiation, proliferation, and peri-tumoural lymphocytes were significantly higher in NBC, indicating the aggressiveness of NBC and the role of chronic inflammation in the development of bladder cancer in neuro-urological patients.
WORLD JOURNAL OF UROLOGY
(2022)
Review
Nursing
Rong Zhang, Dong-Mei Wang, Yong-Li Liu, Man-Li Tian, Ling Zhu, Jing Chen, Jun Zhang
Summary: This article reviews the literature on symptom management in adult patients with brain tumors, including clinical significance and related theoretical framework systems. The study finds that while progress has been made in symptom science for solid tumors, insufficient attention has been given to symptom management for brain tumor patients. Further research is needed to effectively manage symptoms in these patients.
Letter
Urology & Nephrology
Julia Dagnaes-Hansen, Gitte Hjartbro Kristensen, Hein V. Stroomberg, Soren Schwartz Sorensen, Martin Andreas Roder
EUROPEAN UROLOGY FOCUS
(2023)
Article
Urology & Nephrology
Lasse Rehne Jensen, Andreas Roder, Emma Possfelt-Moller, Upender Martin Singh, Mikael Aagaard, Allan Evald Nielsen, Lars Bo Svendsen, Luit Penninga
Summary: This retrospective study aimed to describe the incidence, diagnosis, treatment, and morbidity of lower urinary tract injuries in patients with pelvic fractures. The results showed inconsistent management and severe complications in urethral injuries, while long-term complications mainly occurred in patients with complete urethral ruptures. The treatment and follow-up of urethral injuries were found to be unsystematic even in an experienced medical center.
SCANDINAVIAN JOURNAL OF UROLOGY
(2023)
Article
Anesthesiology
Maja Vejlgaard, Sophia L. Maibom, Ulla N. Joensen, Henrik Kehlet, Morten Bundgaard-Nielsen, Eske K. Aasvang, Andreas Roder
Summary: This study compared the intraoperative and immediate postoperative outcomes between open radical cystectomy (ORC) and robot-assisted radical cystectomy (iRARC). The results showed that iRARC patients had similar recovery compared to ORC patients.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Julie Abildgaard, Hein Vincent Stroomberg, A. Kirstine Bang, Jakob Albrethsen, Laura Smedegaard Kruuse, Anders Juul, Klaus Brasso, Andreas Roder, Niels Jorgensen
Summary: Men with high-risk, non-metastatic prostate cancer receive adjuvant androgen deprivation therapy (ADT) for at least 2 years according to Danish guidelines. It remains unclarified if patients regain the function of the pituitary-testis axis after cessation of ADT. Our study investigated the function of the pituitary-testis axis following adjuvant ADT and found that persistent testosterone deficiency (TD) is a common long-term consequence, equally distributed between pituitary and testicular dysfunction. The study emphasizes the necessity for systematic follow-up of full pituitary-testis axis function in patients receiving adjuvant ADT.
ENDOCRINE-RELATED CANCER
(2023)
Article
Medicine, Research & Experimental
Sophia Liff Maibom, Ulla Nordstroem Joensen, Eske Kvanner Aasvang, Malene Rohrsted, Peter Ole Thind, Per Bagi, Thomas Kistorp, Alicia Martin Poulsen, Lisbeth Nerstrom Salling, Henrik Kehlet, Klaus Brasso, Martin Andreas Roder
Summary: This study aims to investigate the feasibility of conducting a double-blinded randomized controlled trial comparing open cystectomy (ORC) with robot-assisted laparoscopic cystectomy (RARC) in an Enhanced Recovery After Surgery (ERAS) setup. The primary objective is to study the rate of unblinding after surgery and the number of participants who cannot guess the surgical technique. The study endpoints include various complications, length of stay, quality of life, and oncological outcomes.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Oncology
Thea Helene Degett, Ida Rask Moustsen-Helms, Signe Benzon Larsen, Trille Kristina Kjaer, Anne Tjonneland, Susanne Kruger Kjaer, Christoffer Johansen, Ismail Gogenur, Susanne Oksbjerg Dalton
Summary: This study aimed to investigate the risk of new-onset cardiovascular events for patients with stage I-III colorectal cancer who received elective surgery compared to a matched population. The study found that patients operated on for colorectal cancer had an increased risk of heart failure compared to cancer-free individuals. Several potential risk factors for cardiovascular events were also identified.
Article
Medicine, General & Internal
Maura Marcucci, Thomas W. Painter, David Conen, Vladimir Lomivorotov, Daniel Sessler, Matthew T. V. Chan, Flavia K. Borges, Kate Leslie, Emmanuelle Duceppe, Maria Jose Martinez-Zapata, Chew Yin Wang, Denis Xavier, Sandra N. Ofori, Michael Ke Wang, Sergey Efremov, Giovanni Landoni, Ydo Kleinlugtenbelt, Wojciech Szczeklik, Denis Schmartz, Amit X. Garg, Timothy G. Short, Maria Wittmann, Christian S. Meyhoff, Mohammed Amir, David Torres, Ameen Patel, Kurt Ruetzler, Joel L. Parlow, Vikas Tandon, Edith Fleischmann, Carisi A. Polanczyk, Andre Lamy, Raja Jayaram, Sergey V. Astrakov, William Ka Kei Wu, Chao Chia Cheong, Sabry Ayad, Mikhail Kirov, Miriam de Nadal, Valery V. Likhvantsev, Pilar Paniagua, Hector J. Aguado, Kamal Maheshwari, Richard P. Whitlock, Michael H. McGillion, Jessica Vincent, Ingrid Copland, Kumar Balasubramanian, Bruce M. Biccard, Sadeesh Srinathan, Samandar Ismoilov, Shirley Pettit, David Stillo, Andrea Kurz, Emilie P. Belley-Cote, Jessica Spence, William F. McIntyre, Shrikant Bangdiwala, Gordon Guyatt, Salim Yusuf, P. J. Devereaux
Summary: This study compared the effects of two different blood pressure management strategies, hypotension-avoidance and hypertension-avoidance, on major vascular complications after noncardiac surgery. The results showed that both strategies had similar incidence of major vascular complications.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Hein V. Stroomberg, Marc C. M. Andersen, John Thomas Helgstrand, Signe Benzon Larsen, Andrew J. Vickers, Emeritus Klaus Brasso, Andreas Roder
Summary: A study in Denmark involving 37,231 men who had an initial non-malignant transrectal ultrasonography (TRUS) biopsy showed that these men had a higher incidence of subsequent prostate cancer but a lower risk of prostate cancer death compared to the general population. It suggests that the oncological risk of cancers missed in the initial TRUS biopsy is low, and attempts to increase biopsy sensitivity are unwarranted. Current follow-up after a non-malignant biopsy may be overaggressive, especially for men over the age of 60.
Article
Health Care Sciences & Services
Anne Katrine Graudal Levinsen, Trille Kristina Kjaer, Thomas Maltesen, Erik Jakobsen, Ismail Gogenur, Michael Borre, Peer Christiansen, Robert Zachariae, Soren Laurberg, Peter Christensen, Niels Kroman, Signe Benzon Larsen, Thea Helene Degett, Lisbet Rosenkrantz Holmich, Peter de Nully Brown, Christoffer Johansen, Susanne K. Kjaer, Lau Caspar Thygesen, Susanne Oksbjerg Dalton
Summary: Cancer survivors use more healthcare services compared to cancer-free individuals. There is a correlation between educational level and healthcare use, with survivors with lower education being more likely to use general practitioner and acute healthcare services.
BMC HEALTH SERVICES RESEARCH
(2023)
Article
Health Care Sciences & Services
Hein Vincent Stroomberg, S. Benzon Larsen, G. Samso Lanthen, T. Kjaer Nielsen, J. T. Helgstrand, K. Brasso, A. Roder
Summary: This article introduces the Danish Prostate Cancer Registry (DaPCaR) and the Danish Prostate Registry (DanProst), the latter being a comprehensive centralized registry that includes all men who have undergone histological evaluation of the prostate tissue. DanProst is built on the assessment data from the Danish National Registry for Pathology and integrates data from multiple national registries.
JOURNAL OF MEDICAL SYSTEMS
(2023)
Article
Urology & Nephrology
Anna C. L. Halskov, Julia Dagnaes-Hansen, Hein Stroomberg, Soren S. Sorensen, Andreas Roder
Summary: This study investigates the incidence and risk factors for recurrent urinary tract infections (rUTIs) in renal transplant recipients and evaluates the impact on graft and patient survival. The results show that one in six patients experience rUTIs after renal transplantation, and multiple factors such as age, gender, history of lower urinary tract symptoms, and UTI within 30 days of surgery contribute to rUTIs. However, rUTIs do not affect graft function and patient survival.
EUROPEAN UROLOGY OPEN SCIENCE
(2023)
Article
Oncology
Anne Sofie Friberg, Sigrid V. V. Carlsson, Andrew J. J. Vickers, Susanne Oksbjerg Dalton, Signe Benzon Larsen, Lena Saltbaek, Beverley Lim Hoeg, Pernille Envold Bidstrup, Thomas Helgstrand, Andreas Roder, Klaus Brasso, Christoffer Johansen
Summary: The study examined the risk of suicide among prostate cancer patients compared to cancer-free men, taking into consideration clinical stage, socioeconomic position, somatic comorbidity, and previous depression. The risk of suicide was found to be similar between prostate cancer patients and cancer-free men, but it was highest within the first year after diagnosis. Prostate cancer patients with a history of depression had a higher risk of suicide. Healthcare professionals should pay attention to the risk of suicide among men with previous depression following a prostate cancer diagnosis.
Article
Obstetrics & Gynecology
Rikke Groth Olsen, Dorthe Hartwell, Torur Dalsgaard, Mette Elkjaer Madsen, Flemming Bjerrum, Lars Konge, Andreas Roder
Summary: In this study of 12 cases using the Medtronic Hugo robot-assisted surgery system for endometriosis surgery, it was found to be safe and feasible, with high completion rates and minimal postoperative complications, meeting clinical requirements. The advent of new robotic systems is welcomed to advance surgical care for patients worldwide.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
