Review
Biochemistry & Molecular Biology
Stephanie E. Doyle, Finn Snow, Serena Duchi, Cathal D. O'Connell, Carmine Onofrillo, Claudia Di Bella, Elena Pirogova
Summary: Osteochondral (OC) defects are debilitating joint injuries characterized by the loss of full thickness articular cartilage. Current surgical treatments cannot fully repair all components of the OC unit. Recent advancements in additive manufacturing offer new possibilities in developing 3D printed OC scaffolds, but also present challenges such as creating tissue interfaces and co-culturing different cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
You Chen, Yuanyuan Chen, Xiong Xiong, Rongwei Cui, Guowei Zhang, Chen Wang, Dongqin Xiao, Shuxin Qu, Jie Weng
Summary: In this study, a novel hydrogel was developed by hybridizing different materials and pre-crosslinking to enhance osteochondral repair. The research found that the new hydrogel had controllable properties, good cell compatibility, and significantly promoted bone and cartilage repair in experiments.
MATERIALS TODAY BIO
(2022)
Article
Materials Science, Multidisciplinary
Han Yin, Zineng Yan, Jiang Wu, Muzhe Li, Qian Ge, Tieyuan Zhang, Yang Ma, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: This study aimed to investigate the potential of M2 macrophages-derived exosomes (M2D-Exo) to enhance the repair of acellular cartilage extracellular matrix (ACECM) scaffolds. The results showed that M2D-Exo could promote the migration, proliferation, and chondrogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs). It was also found that M2D-Exo could reduce the expression of proinflammatory factors and promote M2 polarization, ultimately protecting chondrocytes and inhibiting chondrocyte apoptosis. In vivo experiments confirmed the efficacy of M2D-Exo in promoting the repair of ACECM scaffolds.
MATERIALS & DESIGN
(2023)
Review
Polymer Science
Elena Iulia Oprita, Andreea Iosageanu, Oana Craciunescu
Summary: This paper reviews the complex structure of osteochondral tissue, the importance of icariin in osteochondral regeneration, and the recent development of hydrogels and scaffolds enriched with icariin. Icariin has chondrogenic and osteogenic effects, making it a promising alternative to growth factors. The use of icariin as a therapeutic approach in regenerative medicine is low-cost and has potential.
Article
Biochemistry & Molecular Biology
Hector Lopez Hernandez, Jason W. Souza, Eric A. Appel
Summary: This study proposes a strategy for determining the property-function relationships of PHs in injectable drug delivery applications at clinically relevant flow rates, aiming to streamline the screening of PHs and enhance their utility in applications with varying constraints.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Orthopedics
Jingqi Liang, Peilong Liu, Xinquan Yang, Liang Liu, Yan Zhang, Qiong Wang, Hongmou Zhao
Summary: This review explores the application of biomaterial-based scaffolds in the treatment of osteoarthritis (OA). These innovative scaffolds mimic the structure of the natural extracellular matrix and stimulate the regeneration of damaged cartilage. The article summarizes the current research landscape, discusses the biomaterials used in scaffold construction, and explores cutting-edge fabrication techniques. By examining both preclinical and clinical studies, the review highlights the potential of biomaterial-based scaffolds in OA therapy.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Nanoscience & Nanotechnology
Xiaoquan Ding, Jingming Gao, Xiaoye Yu, Jiayue Shi, Jun Chen, Lin Yu, Shiyi Chen, Jiandong Ding
Summary: In this study, a bilayered porous scaffold with bioactive peptides was constructed for osteochondral repair. The scaffold showed promising therapeutic efficacy in promoting tissue regeneration and restoring animal gait behavior.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Xiaolin Wu, Mingliang Zhou, Fei Jiang, Shi Yin, Sihan Lin, Guangzheng Yang, Yuezhi Lu, Wenjie Zhang, Xinquan Jiang
Summary: A novel design of a bilayer scaffold combined with a silk sealant for osteochondral repair was reported. Through this design, osteochondral regeneration and lateral integration were achieved in vivo.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Biomedical
David C. Browe, Pedro J. Diaz-Payno, Fiona E. Freeman, Rossana Schipani, Ross Burdis, Daniel P. Ahern, Jessica M. Nulty, Selcan Guler, Lindsey D. Randall, Conor T. Buckley, Pieter A. J. Brama, Daniel J. Kelly
Summary: This study developed a bilayered scaffold for osteochondral defect repair that spatially directs stem cell differentiation and recapitulates the hierarchical structure of native articular cartilage. In vitro and in vivo experiments demonstrated the effectiveness of the scaffold in promoting tissue repair and aligning collagen fibers.
ACTA BIOMATERIALIA
(2022)
Article
Cell & Tissue Engineering
Mi Yeon Ha, Dae Hyeok Yang, Su Jung You, Hyun Joo Kim, Heung Jae Chun
Summary: This study developed an injectable in situ forming composite hydrogel system containing MPEG-PCL and GFOGER-PEG-PCL, and evaluated its performance in vitro and in vivo. In vitro experiments showed that the GFOGER-PEG-PCL hydrogel enhanced expression of integrins and induced downstream signaling of ERK and p38, suggesting its potential for chondrogenic differentiation of BMSCs. In vivo studies using a rat osteochondral defect model demonstrated that the stem cell-laden GFOGER(0.8)-PEG-PCL hydrogel significantly promoted osteochondral regeneration. These findings provide an important platform for future GFOGER-based stem cell research in osteochondral repair.
NPJ REGENERATIVE MEDICINE
(2023)
Article
Engineering, Biomedical
Yanzhi Liu, Liuqi Peng, Lingli Li, Cuishan Huang, Keda Shi, Xiangbo Meng, Pinpin Wang, Mingming Wu, Ling Li, Huijuan Cao, Kefeng Wu, Qingqiang Zeng, Haobo Pan, William Weijia Lu, Ling Qin, Changshun Ruan, Xinluan Wang
Summary: This study developed a BMSC-laden scaffold capable of inhibiting joint inflammation and promoting cartilage defect repair simultaneously. In animal experiments, the scaffold was found to enhance chondrogenesis and significantly improve joint function in the injured leg.
Article
Dentistry, Oral Surgery & Medicine
Y. Yao, J. E. Raymond, F. Kauffmann, S. Maekawa, J. Sugai, J. Lahann, W. Giannobile
Summary: This study designed and fabricated highly ordered multicompartmental scaffolds using melt electrowriting, aiming to mimic the hierarchical structure of native periodontal tissues. The multicompartmental constructs successfully achieved coordinated proliferation and differentiation of multiple cell types in vitro, and effectively recapitulated the key features of interfacial tissues in periodontium. This tissue-engineered approach offers a fundament for engineering periodontal tissue constructs with characteristic 3D microenvironments similar to native tissues.
JOURNAL OF DENTAL RESEARCH
(2022)
Review
Engineering, Biomedical
Le Yu, Sacha Cavelier, Brett Hannon, Mei Wei
Summary: Osteochondral repair is a challenging issue due to the complex structure and poor regeneration ability of natural osteochondral tissue. Tissue engineering strategy, especially the use of multizonal scaffolds (MZSs), has shown promising outcomes in treating OC defects. This review summarizes recent advances, challenges, and future perspectives in OC repair, focusing on the use of MZSs with different compositions and structures, and the demands of architecture designs, material selections, manufacturing techniques, growth factors, and cells.
BIOACTIVE MATERIALS
(2023)
Article
Polymer Science
Pedro Marcelino, Joao Carlos Silva, Carla S. Moura, Joao Meneses, Rachel Cordeiro, Nuno Alves, Paula Pascoal-Faria, Frederico Castelo Ferreira
Summary: Osteochondral (OC) defects affect both articular cartilage and the underlying subchondral bone, and current therapies have not yet found a suitable long-term solution. Tissue engineering (TE) strategies aim to fabricate tissue substitutes that recreate natural tissue features. This study presents a novel method for designing scaffolds with a mathematically defined curvature, based on the geometry of a sphere, to obtain TE constructs mimicking native OC tissue shape.
Article
Polymer Science
Bridget R. Denzer, Rachel J. Kulchar, Richard B. Huang, Jennifer Patterson
Summary: This paper discusses common methods for characterizing the material properties of supramolecular hydrogels, including spectroscopic, diffraction, microscopy, and rheological techniques, as well as future research directions.
Article
Engineering, Biomedical
Wenbo Chen, Yaying Sun, Xueping Gu, Jiangyu Cai, Xingwang Liu, Xingyu Zhang, Jiwu Chen, Yuefeng Hao, Shiyi Chen
Summary: Stem cell-related therapies play a significant role in rotator cuff repair, with their secretome having a significant impact on tendon-bone healing. Research indicates that by modulating macrophage polarization, the conditioned medium of stem cells can promote faster tendon-bone healing.
Article
Engineering, Biomedical
Liang Hao, Jun Chen, Xiliang Shang, Shiyi Chen
Summary: The study found that the simvastatin-loaded silk fibroin membrane had better biocompatibility, promoting the proliferation and osteogenic differentiation of BMSCs, as well as enhancing tendon bone healing and reducing inflammation in chronic rotator cuff injuries. Additionally, it was shown to promote collagen formation and osteogenic differentiation of BMSCs through the activation of the beta-catenin signaling pathway. These results suggest that surface modification of simvastatin-loaded silk fibroin could be a potential strategy for improving healing in rotator cuff injuries and could be applied in clinical practice in the future.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Engineering, Biomedical
Xingyu Zhang, Jianjun Yang, Baochang Cheng, Shenli Zhao, Yao Li, Hui Kang, Shiyi Chen
Summary: A therapeutic drug delivery strategy using magnetic nanoparticles as carriers for cartilage repair was proposed. The magnetic nanocarriers were shown to promote chondrocyte viability and generate cartilage regeneration in a cartilage transplantation model, improving pain-related motor functions.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2021)
Article
Orthopedics
Yimeng Yang, Longhua Qiu, Xueping Gu, Jun Chen, Shiyi Chen, Dan Hu, Yuefeng Hao, Xiliang Shang
Summary: The validity of T1 mapping in monitoring fatty infiltration (FI) progression of rotator cuff muscles was investigated in this study. The results demonstrated that T1 mapping can effectively and quantitatively monitor the FI progression in rotator cuff muscles.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Engineering, Biomedical
K. Sun, R. Fu, X. W. Liu, L. M. Xu, G. Wang, S. Y. Chen, Q. J. Zhai, S. Pauly
Summary: This study found that Zr-based BMG shows excellent cytocompatibility, promotes bone formation, stimulates blood vessel formation, and reduces the pain level during recovery, making it a suitable candidate for biomedical applications.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Xiaoquan Ding, Jingming Gao, Xiaoye Yu, Jiayue Shi, Jun Chen, Lin Yu, Shiyi Chen, Jiandong Ding
Summary: In this study, a bilayered porous scaffold with bioactive peptides was constructed for osteochondral repair. The scaffold showed promising therapeutic efficacy in promoting tissue regeneration and restoring animal gait behavior.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Biomedical
Zhengchao Yuan, Dandan Sheng, Liping Jiang, Muhammad Shafiq, Atta ur Rehman Khan, Rashida Hashim, Yujie Chen, Baojie Li, Xianrui Xie, Jun Chen, Yosry Morsi, Xiumei Mo, Shiyi Chen
Summary: This study developed VEGF-binding aligned electrospun PCL/Gel scaffolds by incorporating BP sequence and demonstrated their potential in promoting ligament regeneration. The functionalized scaffolds accumulated VEGF, enhanced tubular formation of HUVECs and wound healing in vitro, and facilitated the regeneration of matured collagen in patellar ligament in vivo.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Multidisciplinary
Shuquan Cui, Bo Zhang, Liyang Shen, Frank S. Bates, Timothy P. Lodge
Summary: Block polymer self-assembly with bottlebrush architecture allows the creation of materials with unique properties. By studying the phase behavior of bottlebrush block copolymers, it was found that the addition of bottlebrush side chains can lead to the formation of a substantial core-shell double gyroid phase window, with larger network dimensions than before.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Pengzhou Li, Meng Liao, Shuquan Cui, Jiaxin Li, Lei Ye, Yibei Yang, Chuang Wang, Bingjie Wang, Huisheng Peng
Summary: A supramolecular sol-gel transition electrolyte (SGTE) is designed to dynamically accommodate deformations and repair electrode-electrolyte interfaces at low temperatures, offering a promising power solution for wearable electronics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Yiman Wei, Shuquan Cui, Lin Yu, Jiandong Ding
Summary: Biodegradable polymers, especially biomedical materials, play a significant role in the development of new materials. This study focused on the reorganization of hydrolyzable amphiphilic block copolymers during degradation in water, leading to degradation-influenced/induced self-assembly (DISA). Dynamic Monte Carlo simulations and experimental validations revealed three types of self-assembly processes. The findings demonstrate that degradation can be used as a novel strategy to influence the hierarchical self-assembly of amphiphilic block copolymer chains.
Article
Polymer Science
Bo Zhang, Shuquan Cui, Timothy P. Lodge, Frank S. Bates
Summary: In this study, the structure and phase behavior of ternary mixtures containing AB bottlebrush diblock copolymer and A and B linear homopolymers were systematically investigated using small-angle X-ray scattering and cloud point measurements. The overall phase behavior of these mixtures closely resembles the linear counterparts, but with a significantly weaker increase in lamellar and microemulsion domain spacing as the homopolymer content increases. This behavior is attributed to an unconventional spatial distribution of the homopolymer within the bottlebrush architecture of the diblock copolymer. These ternary mixtures offer a promising platform for designing cocontinuous materials with an expanded parameter space using bottlebrush polymers.
Letter
Medicine, General & Internal
Zhi-Wen Luo, Ya-Ying Sun, Wei Xia, Jun-Ying Xu, Dong-Jing Xie, Chun-Meng Jiao, Ji-Ze Dong, Hui Chen, Ren-Wen Wan, Shi-Yi Chen, Jie Mei, Wen-Jun Mao
MILITARY MEDICAL RESEARCH
(2023)
Article
Materials Science, Biomaterials
Qiao Bian, Chao Guo, Shuquan Cui, Jia Liu, Guohua Xu, Wei Feng
Summary: An injectable composite material was developed for bone regeneration, which could be conveniently injected and filled the defect. The composite had good mechanical strength and drug release capability, promoting bone regeneration. In vitro and in vivo experiments demonstrated the excellent performance of the composite, indicating its potential as a promising material for bone regeneration.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Polymer Science
Yiman Wei, Shuquan Cui, Lin Yu, Jiandong Ding
Summary: Biodegradable polymers are important materials, especially in the field of biomedical applications. In this study, a hydrolyzable amphiphilic copolymer was examined and a phenomenon called degradation-influenced/induced self-assembly (DISA) was observed. The study also showed that the extent of degradation is influenced by the molecular weight and dispersity of the copolymer.