Review
Biotechnology & Applied Microbiology
Natalie Chia, Sang Yup Lee, Yaojun Tong
Summary: Optogenetics technique provides a solution to chemical induction with dynamic control and low cost. It utilizes genetically encodable light-sensing modules to fine tune gene expression and protein activity. Recent advancements in microbial synthetic biology have been achieved, but more portable optogenetic tools need to be developed.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Biotechnology & Applied Microbiology
Hao Wang, Lin Wang, Baihua Zhong, Zhuojun Dai
Summary: In this review, we discuss the recent advancements in the field of synthetic biology regarding inteins and their future directions.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Chao Feng, Jing Chen, Wenxin Ye, Kaisen Liao, Zhanshi Wang, Xiaofei Song, Mingqiang Qiao
Summary: Resveratrol, a bioactive natural product, has attracted much attention in the medicine and health care products fields due to its remarkable biological activities. Recent advances in biosynthesis and strain development have provided a safe and efficient route for large-scale resveratrol production. This review summarizes the physiological functions, market applications, and future prospects of resveratrol.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Angel Leon-Buitimea, Francisco de Jesus Balderas-Cisneros, Cesar Rodolfo Garza-Cardenas, Javier Alberto Garza-Cervantes, Jose Ruben Morones-Ramirez
Summary: With the rise of antibiotic-resistant bacterial infections, there is a global health crisis. Overuse, inappropriate prescribing, and lack of innovation have led to an increase in microorganisms that can overcome traditional antimicrobial treatments. Synthetic biology offers a promising strategy to develop new antimicrobial therapies through the engineering of control systems in microbial cells.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Clare M. M. Robinson, Nina E. E. Short, David T. T. Riglar
Summary: The mammalian gut and its microbiome form a complex and dynamic environment, and engineered bacteria with synthetic genetic circuits can provide spatially precise diagnostics and therapeutics for specific biomarkers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Agricultural Engineering
Han Yang, Xiaolong Zhang, Yanfeng Liu, Long Liu, Jianghua Li, Guocheng Du, Jian Chen
Summary: This review discusses the physiological functions and applications of folates, summarizes the latest advances in the development of GRAS strains for folate production, introduces the application of synthetic biology-based metabolic regulatory tools in GRAS strains and their progress in folate production. Challenges in efficient folate production and strategies to overcome them through synthetic biology are also addressed, aiming to enhance the efficiency of microbial folate synthesis.
BIORESOURCE TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Salva Duran-Nebreda, Jordi Pla, Blai Vidiella, Jordi Pinero, Nuria Conde-Pueyo, Ricard Sole
Summary: This article discusses the characteristics of multicellular entities and their spatial patterns related to functions, as well as the repeating distributions in biological structures. It introduces patterning modules and synthetic gene circuits, along with the phenomenon of symmetry-breaking demonstrated through experimental results.
ACS SYNTHETIC BIOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Wenwen Yu, Xianhao Xu, Ke Jin, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu
Summary: This review summarizes the recent advances in the construction and applications of genetically encoded biosensors, including different types of biosensors and their applications in high-value chemical production. The challenges and prospects for constructing robust and sophisticated biosensors are also discussed.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Engineering, Electrical & Electronic
Jamie A. Davies
Summary: Synthetic morphogenesis is a new engineering discipline that genetically engineers cells to create designed shapes and structures. Devices in this field utilize natural shape-generating processes from embryonic development, but artificially manipulate them according to a technologist's preferences. Synthetic morphogenesis enables the construction of two-way interfaces between living organisms and electronic devices, facilitating unprecedented information flow and control.
PROCEEDINGS OF THE IEEE
(2022)
Editorial Material
Biochemical Research Methods
Michael B. Sheets, Joshua T. Atkinson, Mark P. Styczynski, Emily R. Aurand
Summary: As engineering biology continues to have increasing impacts, it is crucial to introduce the field early on in an accessible manner. However, teaching engineering biology faces challenges such as limited representation in widely used scientific textbooks or curricula, as well as its interdisciplinary nature. To address this, we have developed an adaptable curriculum module that provides a versatile slide deck designed by engineering biology experts to cover the fundamental principles and applications of the field. Free and accessible through a public website, this module can be used independently or integrated into existing curricula, aiming to enhance the ease of teaching current engineering biology topics and promote public engagement with the field.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jun Geng, Boyang Ji, Gang Li, Felipe Lopez-Isunza, Jens Nielsen
Summary: Microbial variations in the human gut are complex and understanding how microbiota colonize in the gut is a key challenge. The CODY framework integrates species-level modeling of microbial dynamics and ecosystem-level interactions to predict spatiotemporal dynamic changes in the gut microbiota, demonstrating effectiveness in predicting microbial variations in response to diet interventions. Model simulations provide insight into the biogeographical heterogeneity among lumen, mucus, and feces, shaping microbial structure and functionality.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Chemistry, Multidisciplinary
Yuval Elani
Summary: The construction of artificial cells is a major challenge today, with potential applications in clinical and industrial settings. Artificial cells currently cannot match the complexity of biological cells, leading researchers to explore hybrid living/synthetic systems that combine the advantages of both.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biotechnology & Applied Microbiology
Javad Aminian-Dehkordi, Shadi Rahimi, Mehdi Golzar-Ahmadi, Amritpal Singh, Javiera Lopez, Rodrigo Ledesma-Amaro, Ivan Mijakovic
Summary: Synthetic biology offers new solutions for environmental protection by developing remediation systems using genetically engineered microbes and plants, and utilizing computational methods for design and application to detect and respond to specific pollutants.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Multidisciplinary Sciences
Luna Rizik, Loai Danial, Mouna Habib, Ron Weiss, Ramez Daniel
Summary: Researchers have utilized the perceptgene technology to create synthetic gene circuits based on the computational properties of neuronal networks. These circuits can perform non-binary logic computation and signal processing, and can be modified for different tasks by adjusting parameters.
NATURE COMMUNICATIONS
(2022)
Review
Food Science & Technology
Jorge Armando Jimenez-Avalos, Gerardo Arrevillaga-Boni, Lorena Gonzalez-Lopez, Zaira Yunuen Garcia-Carvajal, Marisela Gonzalez-Avila
Summary: A healthy Human Gut Microbial Ecosystem (HGME) is essential for the proper functioning of the body, with dysbiosis potentially leading to various disorders. Different methods such as diet, probiotics, antibiotics, and Fecal Microbiota Transplantation (FMT) can help restore or maintain the balance of Gut Microbiota (GM) populations. New approaches such as engineered nanomaterials, phagotherapy, antimicrobial peptides, non-antibiotic drugs, vaccines, and immunoglobulins are promising strategies for modulating HGME.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Vince W. Kelly, Shannon J. Sirk
Summary: In research on therapeutic antibodies, modifying antibody fragments with short FcRn-binding peptide domains enhances their binding with FcRn to achieve recycling and transmembrane transcytosis. Further studies show that rational, single amino acid mutations to the peptide sequence significantly impact the receptor-mediated function and the underlying structural basis is investigated using computational modeling. Finally, the identification of a short peptide from human serum albumin enables FcRn-mediated function when grafted onto a single-chain variable fragment (scFv) scaffold.
ACS CHEMICAL BIOLOGY
(2022)
