Article
Orthopedics
Benjamin J. Levy, Mary Beth McCarthy, Amir Lebaschi, Melinda M. Sanders, Mark P. Cote, Augustus D. Mazzocca
Summary: This study identified significant concentrations of progenitor cells and fibroblast-type cells in the subacromial bursal tissue of patients undergoing rotator cuff repair, with prominent amounts of fat and proteoglycans present in the matrix.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2022)
Article
Orthopedics
Xiaopeng Tong, Yan Xu, Tao Zhang, Chao Deng, Jinrui Xun, Deyi Sun, Daqi Xu
Summary: This study investigates the effect of exosomes derived from human urine-derived stem cells (USCs) and their subpopulations (CD133+USCs) on the regeneration of fibrocartilage tissue between tendon and bone during rotator cuff repair. The findings suggest that CD133+ USC-Exos hydrogel complex may be a promising therapeutic approach for rotator cuff healing.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Medicine, General & Internal
Daichi Morikawa, Benjamin C. Hawthorne, Mary Beth R. McCarthy, Nicholas Bellas, Jeremiah D. Johnson, Maxwell T. Trudeau, Kyle Murphy, Michael R. Mancini, Matthew R. LeVasseur, Mark P. Cote, Augustus D. Mazzocca
Summary: The study found that patient demographics did not significantly affect the number of CFUs or NCC of CTPs derived from the SB, but tear size was negatively correlated with CFUs. This suggests that tear size, rather than patient demographics, may influence the viability of CTPs and should be considered in augmenting RC repairs with SB.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Hao-Nan Wang, Xiao Rong, Lu-Ming Yang, Wei-Zhong Hua, Guo-Xin Ni
Summary: This review summarizes the advances of stem cells and stem cell-derived extracellular vesicles (EVs) in the repair of rotator cuff injuries, highlighting the underlying mechanisms and suggesting future directions for research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mark Lundeen, Jason L. Hurd, Matthew Hayes, Meredith Hayes, Tiffany R. Facile, John P. Furia, Nicola Maffulli, Christopher Alt, Eckhard U. Alt, Christoph Schmitz, David A. Pearce
Summary: This study found that the use of UA-ADRCs injections for sPTRCT treatment is more effective than corticosteroid injections in the long run and carries no greater risks. Subjects in the UA-ADRCs group showed significantly higher ASES Total scores.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Jieun Baek, Bokyeong Ryu, Jin Kim, Seul-Gi Lee, Min-Seok Oh, Ki-Sung Hong, Eun-Young Kim, C-Yoon Kim, Hyung-Min Chung
Summary: This study compared M-MSCs with adult-MSCs and found that M-MSCs have the potential to be used in next-generation therapies for rotator cuff tears (RCTs). They are able to regulate inflammation and promote tissue repair, leading to improved muscle recovery in RCTs.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
Review
Orthopedics
Zetao Wang, Youguo Liao, Canlong Wang, Chenqi Tang, Cailian Fang, Junchao Luo, Hengzhi Liu, Xianan Mo, Zicheng Wang, Lingfang Shen, Junjuan Wang, Xiao Chen, Zi Yin, Jianyou Li, Weiliang Shen
Summary: Rotator cuff tendinopathy is a common disorder that causes a significant burden. Although stem cell therapy has shown promising results, there are many unresolved issues, such as determining the optimal source and dosage of stem cells, as well as standardizing patient types.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Materials Science, Multidisciplinary
Xiping Jiang, Yunfan Kong, Mitchell Kuss, Joel Weisenburger, Hani Haider, Robert Harms, Wen Shi, Bo Liu, Wen Xue, Jianghu Dong, Jingwei Xie, Philipp Streubel, Bin Duan
Summary: This study presents a novel therapeutic method that combines three-dimensional (3D) bioprinting and melt electrospinning writing techniques to regenerate the tendon-to-bone interface. The use of 3D-bioprinted pre-differentiated autologous adipose-derived mesenchymal stem cells (ADMSC) generated biomimetic multilayered scaffolds that recapitulated the compositional and cellular structures of the interface. In vivo studies demonstrated the superior histological score and improved collagen organization of the scaffold with spatially differentiated autologous ADMSCs.
APPLIED MATERIALS TODAY
(2022)
Article
Medicine, General & Internal
Ian J. Wellington, Lukas N. Muench, Benjamin C. Hawthorne, Colin L. Uyeki, Christopher L. Antonacci, Mary Beth McCarthy, John P. Connors, Cameron Kia, Augustus D. Mazzocca, Daniel P. Berthold
Summary: The use of biologically enhanced demineralized bone matrix augmentation in the repair of complex rotator cuff tears shows promise in improving clinical outcomes. However, 50% of the patients in this study demonstrated failure of supraspinatus healing according to post-operative MRI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Peter Lapner, Martin Bouliane, J. W. Pollock, Stephanie Coupal, Elham Sabri, Taryn Hodgdon, Jason Old, Katie Mcilquham, Peter MacDonald, CSES Investigators
Summary: Bone channeling may attract autologous mesenchymal stem cells, cytokines, and growth factors to the repair site, resulting in a higher healing rate in arthroscopic rotator cuff repair.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Engineering, Biomedical
Wenbo Chen, Yaying Sun, Xueping Gu, Jiangyu Cai, Xingwang Liu, Xingyu Zhang, Jiwu Chen, Yuefeng Hao, Shiyi Chen
Summary: Stem cell-related therapies play a significant role in rotator cuff repair, with their secretome having a significant impact on tendon-bone healing. Research indicates that by modulating macrophage polarization, the conditioned medium of stem cells can promote faster tendon-bone healing.
Article
Orthopedics
Liren Wang, Yuhao Kang, Guoming Xie, Jiangyu Cai, Chang'an Chen, Xiaoyu Yan, Jia Jiang, Jinzhong Zhao
Summary: Severe rotator cable tears do not significantly impair rotator cuff function, while tears involving all rotator cuff tissue above the humeral head rotation center result in obvious functional impairment.
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2021)
Article
Rehabilitation
Alan Z. Grusky, Amos Song, Peter Kim, Gregory D. Ayers, Laurence D. Higgins, John E. Kuhn, Keith M. Baumgarten, Elizabeth Matzkin, Nitin B. Jain
Summary: In a cohort of patients with shoulder pain, older age, involvement of the dominant shoulder, and a higher body mass index were found to be independently associated with rotator cuff tears. Further research is needed to understand the mechanisms behind these associations.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Orthopedics
Ya Song, Ping Li, Yan Xu, Zhangyuan Lin, Zhenhan Deng, Can Chen
Summary: Human MenSCs encapsulated in autologous platelet-rich gel (APG) promote the healing of chronic rotator cuff tears by enhancing the formation of new bone tissue and regenerating mature fibrocartilage. This treatment also improves the mechanical properties of the repaired cuff.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
