Article
Multidisciplinary Sciences
Uxio Meis-Pinheiro, Francesc Lopez-Segui, Sandra Walsh, Anton Ussi, Sebastia Santaeugenia, Jose Augusto Garcia-Navarro, Antonio San-Jose, Antoni L. Andreu, Magda Campins, Benito Almirante
Summary: This study investigated the natural history of COVID-19 in older adults and found that some comorbidities and symptoms have a strong predictive value for mortality. The infection rate was 28%, with 71% of residents showing symptoms, including fever and dyspnea. The study provides insights into the disease progression and mortality predictors in long-term nursing homes during the early months of the pandemic.
Article
Cardiac & Cardiovascular Systems
Mladen Jergovic, Christopher P. Coplen, Jennifer L. Uhrlaub, Janko Nikolich-Zugich
Summary: SARS-CoV-2, the third highly pathogenic coronavirus to emerge in the human population in the last two decades, shows age-dependent pathology with more severe symptoms and mortality in older and frail humans. Infectious diseases have always been a major cause of death in older adults, whose immune function tends to decline with age.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Virology
Rabia Bag Soytas, Mahir Cengiz, Mehmet Sami Islamoglu, Betul Borku Uysal, Hande Ikitimur, Hakan Yavuzer, Serap Yavuzer
Summary: Elevated levels of COVID-19 IgG antibodies were found in older patients, particularly in the first 3 months after a positive RT-PCR test. Patients aged 80 and above demonstrated higher antibody titers compared to those in the 60-69 and 70-79 age ranges. This suggests a potential link between high antibody levels and disease severity in older adults with COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Medicine, General & Internal
Jose Rivera-Torres, Natalia Giron, Esther San Jose
Summary: This article reviews the impact of COVID-19 on older adults, specifically its effects on the respiratory, cardiovascular, and immune systems. Aging and comorbidities are risk factors for severe illness and poor prognosis. Understanding the underlying mechanisms of these pathologies is crucial for improved medical care for elderly COVID-19 patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Infectious Diseases
Virginie Prendki, Giusy Tiseo, Marco Falcone
Summary: There are unmet needs in the care for elderly patients with COVID-19, including differences in typical clinical presentation, high mortality rates, long-term sequelae risks, and issues regarding the durability and need for booster doses of vaccines.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Cardiac & Cardiovascular Systems
A. G. Buenen, Marijn Sinkeldam, Martje L. Maas, Martha Verdonschot, Peter C. Wever
Summary: This observational study found that the prior use of anticoagulation was associated with better survival outcomes in COVID-19 patients, with potential additional benefits from DOACs, especially dabigatran.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Nutrition & Dietetics
Maria Dolores Arenas Jimenez, Emilio Gonzalez-Parra, Marta Riera, Abraham Rincon Bello, Ana Lopez-Herradon, Higini Cao, Sara Hurtado, Silvia Collado, Laura Ribera, Francesc Barbosa, Fabiola Dapena, Vicent Torregrosa, Jose-Jesus Broseta, Carlos Soto Montanez, Juan F. Navarro-Gonzalez, Rosa Ramos, Jordi Bover, Xavier Nogues-Solan, Marta Crespo, Adriana S. Dusso, Julio Pascual
Summary: The study suggests that the use of paricalcitol, calcimimetics, or a combination of both may be associated with improved survival in HD patients with COVID-19. However, there was no correlation found between serum vitamin D levels and prognosis or outcomes in these patients. Prospective studies and clinical trials are needed to further validate these findings.
Article
Cardiac & Cardiovascular Systems
Rebecca Cope, Briann Fischetti, Nourhan Eladghm, Mahy Elaskandrany, Nardine Karam
Summary: During the COVID-19 pandemic, TBHC's anticoagulation clinic implemented measures such as telemedicine follow-ups and extending INR testing intervals, but there was no significant reduction in the time patients spent in the therapeutic range or other secondary outcomes.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Cardiac & Cardiovascular Systems
A. John Camm, Keith A. A. Fox, Saverio Virdone, Jean-Pierre Bassand, David A. Fitzmaurice, Samuel Berchuck, Bernard J. Gersh, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Freek W. A. Verheugt, Riccardo Cappato, Ajay K. Kakkar
Summary: In patients with atrial fibrillation at risk of stroke, non-vitamin K antagonist oral anticoagulants (NOACs) showed lower risks of all-cause mortality and major bleeding compared to vitamin K antagonists (VKAs), with similar risks of non-haemorrhagic stroke/systemic embolism.
Article
Cardiac & Cardiovascular Systems
Jose Miguel Rivera-Caravaca, Stephanie L. Harrison, Benjamin J. R. Buckley, Elnara Fazio-Eynullayeva, Paula Underhill, Francisco Marin, Gregory Y. H. Lip
Summary: In COVID-19 outpatients with cardiometabolic diseases, prior use of DOAC therapy compared to VKA therapy at the time of COVID-19 diagnosis demonstrated lower risk of arterial or venous thrombotic outcomes, without increasing the risk of bleeding.
CARDIOVASCULAR DIABETOLOGY
(2021)
Review
Medicine, General & Internal
Peter L. Gross, Noel C. Chan
Summary: Older adults are more prone to arterial and venous thromboembolism, making the use of anticoagulants crucial but requiring careful consideration of the balance between risk and benefit, especially in the very elderly population. The challenges of implementing and managing anticoagulant therapy in older patients are further complicated by the availability of multiple options including VKAs and DOACs.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Ji-Young Kwon, Sung-Goo Kang
Summary: This study investigated the changes in vitamin D levels and deficiency prevalence among Korean adults during the COVID-19 pandemic. The results showed an increase in vitamin D levels and a decrease in deficiency prevalence during the pandemic.
Article
Medicine, General & Internal
Enrico Guido Spinoni, Chiara Ghiglieno, Simona Costantino, Eleonora Battistini, Gabriele Dell'Era, Stefano Porcellini, Matteo Santagostino, Federica De Vecchi, Giulia Renda, Giuseppe Patti
Summary: This study compares the occurrence of post-procedural bleeding complications between patients with atrial fibrillation undergoing cardiac implantable electronic device (CIED) intervention who were treated with non-vitamin K antagonist anticoagulants (NOACs) or vitamin K antagonist anticoagulants (VKAs). The results suggest that NOACs may be associated with a lower incidence of post-intervention pocket hematoma compared to VKAs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Claudio Tana, Livia Moffa, Katia Falasca, Jacopo Vecchiet, Marco Tana, Cesare Mantini, Fabrizio Ricci, Andrea Ticinesi, Tiziana Meschi, Francesco Cipollone, Maria Adele Giamberardino
Summary: This review aims to discuss the impact of COVID-19 in vulnerable populations and provide recommendations for personalized care plans for older adults to improve treatment outcomes.
ANNALS OF MEDICINE
(2023)
Article
Immunology
Ankita P. Desai, Sahera Dirajlal-Fargo, Jared C. Durieux, Heather Tribout, Danielle Labbato, Grace A. McComsey
Summary: This study found that vitamin K and vitamin D deficiencies were independently associated with worse severity of COVID-19 in patients, suggesting a potential synergistic interplay between these two vitamins in COVID-19.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Acoustics
Antoine Moret, Jerome Boursier, Pauline Houssel Debry, Jeremie Riou, Anne Crouan, Marine Dubois, Sophie Michalak Provost, Christophe Aube, Anita Paisant
ULTRASCHALL IN DER MEDIZIN
(2022)
Article
Biology
Paul Blanche, Jean-Francois Dartigues, Jeremie Riou
Summary: This paper presents an efficient method for comparing prognostic biomarkers by combining the max-t test and closed testing procedures to control the family-wise error rate. The method takes into account correlations between test statistics and logical constraints between null hypotheses. It outperforms other popular procedures and can be applied in various contexts.
Article
Transplantation
Samuel Wacrenier, Jeremie Riou, Pierre Jourdain, Fanny Guibert, Nicolas Henry, Assia Djema, Jean-Philippe Coindre, Romain Crochette, Maud Cousin, Anne Croue, Jean-Francois Subra, Giorgina Piccoli, Jean-Francois Augusto, Benoit Brilland
Summary: Lymphopaenia is associated with the severity of AAV glomerulonephritis at diagnosis and predicts poor renal outcome in AAV-RI patients. Therefore, lymphopaenia could be used as a simple and cost-effective biomarker to assess renal prognosis at AAV-RI diagnosis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Clement Samoreau, Giorgina Barbara Piccoli, Cecile Martin, Philippe Gatault, Emeline Vinatier, Frank Bridoux, Jeremie Riou, Alice Desouche, Pierre Jourdain, Jean-Philippe Coindre, Samuel Wacrenier, Fanny Guibert, Nicolas Henry, Odile Blanchet, Anne Croue, Assia Djema, Lise-Marie Pouteau, Marie-Christine Copin, Celine Beauvillain, Jean-Francois Subra, Jean-Francois Augusto, Benoit Brilland
Summary: This study found that ANCA specificity is associated with the progression and renal prognosis of ANCA-associated vasculitis with glomerulonephritis. Recurrent or persistent MPO-ANCA is associated with lower renal recovery potential and higher risk of kidney failure, while recurrent or persistent PR3-ANCA is associated with a greater risk of relapse. Therefore, ANCA kinetics can help identify patients with a smouldering disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Guillaume T. Duval, Anne-Marie Schott, Dolores Sanchez-Rodriguez, Francois R. Herrmann, Cedric Annweiler
Summary: The study suggests that older women born in the summer to early fall months have higher muscle mass and strength.
Article
Hematology
Amelie Bachelot, Anne Bouvier, Jeremie Riou, Sylvain Thepot, Aurelien Giltat, Christopher Nunes Gomes, Jerome Paillassa, Rebecca Jouanneau-Courville, Maxime Renard, Annaelle Beucher, Laurane Cottin, Margaux Wiber, Benedicte Ribourtout, Franck Genevieve, Damien Luque Paz, Aline Tanguy-Schmidt, Valerie Ugo, Mathilde Hunault-Berger, Odile Blanchet, Corentin Orvain
Summary: The aim of this study was to evaluate the relationship between comorbidities, molecular landscape, and outcome in acute myeloid leukemia (AML) patients aged 60 years or older who underwent intensive induction therapy. Next-generation sequencing identified 323 mutations in 77 genes among 91 patients, with NPM1, FLT3, TET2, and DNMT3A being the most frequently mutated genes. Different mutations were associated with achieving complete remission, primary refractory disease, and mortality after relapse. Short-term outcome was best predicted by Ferrara unfitness criteria and performance status, while genomic classifications were better predictors of long-term outcome. It is suggested that specific prognostic classifications should be designed for AML patients over 60 years, taking into consideration performance status, comorbidities, and cytogenetic/molecular data.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Hematology
Christophe Desprez, Achille Kouatchet, Tony Marchand, Jean Baptiste Mear, Jean Marc Tadie, Pierre Peterlin, Patrice Chevalier, Emmanuel Canet, Marie-Anne Couturier, Gaelle Guillerm, Laetitia Bodenes, Emmanuel Gyan, Alban Villate, Stephan Ehrmann, Anne Lebreton, Marie-Antoinette Lester, Clementine Fronteau, Gaelle Larhantec, Virginie Andre, Jeremie Riou, Mathilde Hunault-Berger, Aline Schmidt-Tanguy, Corentin Orvain
Summary: Acute myeloid leukemia (AML) patients requiring intensive care unit (ICU) admission had positive outcomes during induction therapy, but the potential benefit of early preemptive (ePE) ICU admission strategy needs to be confirmed prospectively.
ANNALS OF HEMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Clemence Moreau, Marine Roux, Jeremie Riou, Clemence M. Canivet, Etienne Audureau, Clovis Lusivika-Nzinga, Pierre Nahon, Fabrice Carrat, Jerome Boursier
Summary: This study aimed to evaluate whether the dynamics of multiple measurements of simple parameters after sustained viral response (SVR) enable the development of a personalized prediction of prognosis in patients with hepatitis C virus (HCV) chronic infection. The study found that FIB4 was a biomarker associated with liver-related complications (LRC) occurrence after SVR. The results suggest that dynamic modeling using repeated measurements of simple parameters predicts the individual residual risk of LRC and improves personalized medicine after SVR in HCV patients.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Multidisciplinary Sciences
Francois Morin, Delphine Douillet, Jean Francois Hamel, Dominique Savary, Christophe Aube, Karim Tazarourte, Kamelia Marouf, Florence Dupriez, Phillipe Le Conte, Thomas Flament, Thomas Delomas, Mehdi Taalba, Nicolas Marjanovic, Francis Couturaud, Nicolas Peschanski, Thomas Boishardy, Jeremie Riou, Vincent Dubee, Pierre-Marie Roy
Summary: L-POCUS is effective in detecting pulmonary peripheral patterns and can early identify non-critical COVID-19 patients at high risk of worsening.
Article
Multidisciplinary Sciences
Guillaume Duval, Anne-Marie Schott, Yves Rolland, Jennifer Gautier, Hubert Blain, Gustavo Duque, Cedric Annweiler
Summary: This study found that a decrease in systolic blood pressure while standing was associated with baseline cognitive impairment in older women, but orthostatic hypotension itself and a decrease in diastolic blood pressure while standing were not. Furthermore, none of these factors could predict incident cognitive decline after 7 years. This suggests that the relationship between orthostatic hypotension and cognitive impairment is more complex than previously thought.
Article
Critical Care Medicine
Rafael Mahieu, Carole Lemarie, Delphine Douillet, Alain Mercat, Helene Cormier, Matthieu Eveillard, Vincent Dubee, Jeremie Riou, Achille Kouatchet
Summary: A multi-faceted program based on UBC can effectively reduce blood culture contamination rate without affecting their yield. In ICU patients, the use of UBC strategy significantly reduces the occurrence of blood culture contamination.
ANNALS OF INTENSIVE CARE
(2023)
Article
Multidisciplinary Sciences
Olivier Briere, Marie Otekpo, Marine Asfar, Jennifer Gautier, Guillaume Sacco, Cedric Annweiler
Summary: The study aimed to determine whether baseline functional disability in older patients hospitalized for COVID-19 was associated with mortality risk after 1 year. The results showed that initial functional disability was associated with poorer survival in hospitalized frail elderly COVID-19 patients.
Review
Health Care Sciences & Services
Clemence Moreau, Jeremie Riou, Marine Roux
Summary: With the development of personalized medicine, the study of individual prognosis becomes important. Dynamic models are suitable for such studies, allowing potential changes in follow-up. We propose a new procedure to compare predictive abilities of different biomarkers based on dynamic area under the receiver operating characteristic curve or Brier score.
STATISTICAL METHODS IN MEDICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Dorien De Meester, Mathijs Goossens, Ester Marco, Marie Claessens, Jennifer Gautier, Cedric Annweiler, Siddhartha Lieten, Florence Benoit, Murielle Surquin, Dolores Sanchez-Rodriguez
Summary: The Geriatric Nutritional Risk Index (GNRI) on hospital admission was found to be associated with increased 14-day mortality risk in older inpatients with COVID-19. A GNRI score of <= 98 indicated a risk of malnutrition. However, no association was found between GNRI and 12-month mortality risk. Further studies are needed to validate the short-term predictive value of GNRI in this population.
CLINICAL NUTRITION ESPEN
(2023)
