Article
Mechanics
Hassan Mehboob, Ali Mehboob, Fethi Abbassi, Furqan Ahmad, Seung-Hwan Chang
Summary: In this study, partially biodegradable titanium/polyglycolic acid (Ti/PGA) composite cubes were designed and compressive simulations were conducted. The results showed that reducing the Young's modulus of the bone plate increased the callus volume and promoted the healing process.
COMPOSITE STRUCTURES
(2022)
Article
Materials Science, Multidisciplinary
Ricardo Donate, Ruben Paz, Rocio Moriche, Maria Jesus Sayagues, Maria Elena Aleman-Dominguez, Mario Monzon
Summary: Despite the lack of functionalities in current biomaterials for osseous diseases treatment, the development of piezoelectric scaffolds shows promise for improved bone regeneration. These scaffolds can positively influence stem cell proliferation and differentiation, and various mechanical stimuli can activate their piezoelectric effect. Biocompatible, piezoelectric polymers are being explored for additive manufacturing of composite scaffolds, with the addition of piezoceramic nanoparticles enhancing their properties. These scaffolds also have potential for real-time monitoring.
MATERIALS & DESIGN
(2023)
Article
Materials Science, Ceramics
Amit Kumar, Kartikeya Dixit, Niraj Sinha
Summary: During the fabrication process of bone regeneration scaffolds, it is challenging to achieve bioactivity, mechanical performance, and ease of fabrication simultaneously. This study reports on the development of additively manufactured (AM) 45S5 Bioglass scaffolds reinforced with functionalized multi-walled carbon nanotubes (CNTs) coated with cellulose nanowhiskers (CNWs). The fabricated scaffolds were characterized using various techniques and exhibited improved compressive strength and toughness. Moreover, the scaffolds showed suitable porosity, pore size, pore throat size, and interconnectivity, and the coating increased the surface roughness for enhanced bone cell attachment. In vitro studies also demonstrated the bioactivity of the scaffolds in simulated body fluid (SBF). These findings highlight the potential for efficient fabrication of hybrid scaffolds with controlled structure, bioactivity, and required toughness and strength for bone tissue engineering.
CERAMICS INTERNATIONAL
(2023)
Article
Polymer Science
Alberto David Pertuz-Comas, Jorge G. Diaz, Oscar Javier Meneses-Duran, Nixon Yesid Nino-Alvarez, Juan Leon-Becerra
Summary: Fatigue bending tests were performed on a polymer matrix composite material reinforced with continuous Kevlar fibers under controlled displacement. Static characterization and numerical modeling were used to analyze the material properties and fatigue behavior. Morphological analysis of the fractured surface revealed different failure mechanisms.
Article
Biophysics
Minufar Abdollahi Khabisi, Farhad Shirini, Kasra Shirini, Hamid Khorsand, Max Marian, Andreas Rosenkranz
Summary: Human bones can suffer from various injuries, leading to the need for bone replacement using advanced bio-materials. MAX-phases and MXenes have gained attention for their unique properties and potential in bone tissue engineering. Additive manufacturing allows for the fabrication of bio-scaffolds with controlled porosity and complex shapes. However, there is a lack of comprehensive articles summarizing the use of MAX-phases and MXenes in bone scaffolds. Our article addresses this gap and discusses the importance of material choice, recent developments, and future potential.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Chemistry, Physical
Wojciech Czyzewski, Jakub Jachimczyk, Zofia Hoffman, Michal Szymoniuk, Jakub Litak, Marcin Maciejewski, Krzysztof Kura, Radoslaw Rola, Kamil Torres
Summary: This study investigates the use of 3D printing technology to produce polymer-based prostheses, aiming to improve the accessibility of cranioplasty. Patient-specific 3D printed prostheses are modeled using CAD software, and budget 3D-printed endoprostheses are found to be cheaper and reliable.
Article
Biotechnology & Applied Microbiology
Francesco Dalle Mura, Lapo Governi, Rocco Furferi, Marta Cervo, Luca Puggelli
Summary: Burn injuries require long-term management and treatment, and the methods used to evaluate burn scars often lack precision. This research aims to design and build a prototype tool to support doctors in scar assessment and therapy by providing objective information on the state of the lesion, particularly skin pliability. The prototype is based on a depressomassage treatment probe named LPG and is manufactured using Additive Manufacturing. Validation tests show that the prototype can provide measurements with sufficient accuracy to estimate the pliability value in a hospital environment.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Antonio Marzola, Francesco Buonamici, Rocco Furferi, Lapo Governi, Lorenzo Genitori, Federico Mussa
Summary: Cranioplasty is a surgical procedure to repair defects in the human skull bone, with potential complications that can impact the surgical outcome; this paper presents an innovative method that utilizes digital analyses and physical simulations to enhance the success rate.
APPLIED SCIENCES-BASEL
(2021)
Article
Materials Science, Multidisciplinary
Usman Bashir, Abrar Hassan, Furqan Ahmed, Muhammad Zain-ul-abdein, Hajrah Mobeen, Abdullah Dildar, Qamar Hayat, Hassan Ijaz, Muhammad Asad, Faramarz Djavanroodi
Summary: This paper proposes a numerical approach to predict residual stresses and their effects on the deformation behavior of polymer composites during additive manufacturing. A finite element model was developed to simulate 3D printing of layered polymer composites using three different polymers. The results showed that the estimated material properties were significantly different from those calculated by theoretical models due to the presence of residual stresses.
MECHANICS OF ADVANCED MATERIALS AND STRUCTURES
(2023)
Article
Mechanics
Leo Demont, Nicolas Ducoulombier, Romain Mesnil, Jean-Francois Caron
Summary: The majority of extrusion-based concrete additive manufacturing focuses on unreinforced mortar, but the lack of reinforcement limits its industrial development. A new reinforcement method called flow-based pultrusion (FBP) is introduced in this paper, which uses continuous fiber rovings to increase the yield stress of the mortar and create anisotropic concrete.
COMPOSITE STRUCTURES
(2021)
Article
Mathematics
Inigo Calderon-Uriszar-Aldaca, Sergio Perez, Ravi Sinha, Maria Camara-Torres, Sara Villanueva, Carlos Mota, Alessandro Patelli, Amaia Matanza, Lorenzo Moroni, Alberto Sanchez
Summary: Finite element modeling was used to simulate AM scaffolds for bone tissue regeneration, with experimental validation using polymer and nano-filler composites. The simulations overestimated scaffold performance due to lack of printing accuracy, highlighting the importance of calibration for expected scenarios.
Article
Polymer Science
Seyyed Kaveh Hedayati, Amir Hossein Behravesh, Sadegh Hasannia, Omid Kordi, Majid Pourghaumi, Arvin Bagheri Saed, Fatemeh Gashtasbi
Summary: This study successfully implemented in-situ impregnation in the FDM process to produce PCL scaffolds with enhanced mechanical and biological properties by incorporating PGA fibers and nHA particles. The composite scaffolds exhibited superior water uptake and hydrophilicity, making them suitable for bone tissue engineering and resorbable barrier membranes.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Mechanics
Hailun Zhou, David Z. Zhang, Naihui He, Miao Zhao
Summary: Compared with single-morphology lattice structures, multi-morphology composite lattice structure has the potential to achieve customizable mechanical properties by modifying the architectural feature of substructures. Inspired by Sigmoid mathematical function, a new parametrical design method for composite lattice structure was proposed by combining two cell lattice structs with complementary spatial distribution of elastic modulus. The results show that the anisotropy control strategy of elastic modulus is achieved by changing the design variables.
COMPOSITE STRUCTURES
(2023)
Article
Engineering, Manufacturing
Frederik Wulle, Oliver Gorke, Sarah Schmidt, Maximilian Nistler, Gunter E. Tover, Oliver Riedel, Alexanser Verl, Achim Weber, Alexanser Southan
Summary: This paper introduces the potential and advantages of multi-axis 3D printing of hydrogels, and demonstrates through experiments the relative flexibility and water absorbency of 3D printed hydrogels compared to conventional molded hydrogels. The research also highlights related research questions, such as cross-linking chemistry and formulation of hydrogel inks.
ADDITIVE MANUFACTURING
(2022)
Article
Construction & Building Technology
Marcin Malek, Krzysztof Grzelak, Waldemar Lasica, Mateusz Jackowski, Janusz Kluczynski, Ireneusz Szachogluchowicz, Janusz Torzewski, Jakub Luszczek
Summary: This study proposes an alternative approach to address the impact of the construction industry on climate change by using a cement-glass composite brick with a printed internal scaffold made from recycled PET-G. The results showed that the CGCB has better thermal properties but reduced flexural and compressive strength compared to traditional cement-glass mortar.
JOURNAL OF BUILDING ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Teresa Russo, Valentina Peluso, Pierpaolo Fucile, Roberto De Santis, Antonio Gloria
Summary: Tissue engineering is an important guiding strategy in oral and maxillofacial surgery and various dental disciplines, with a wide range of techniques and materials being studied and applied. Recent innovations in surgery and growth factors have also been extensively researched. This review paper highlights the innovative strategies and technological approaches in oral and maxillofacial tissue engineering, providing information on scientific data and practical applications.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Physical
Pietro Ausiello, Eleonora Bolli, Saulius Kaciulis, Antonio Gloria, Antonio Lanzotti, Massimo Martorelli, Alessio Mezzi, Roberto Montanari, Maria Richetta, Alessandra Varone
Summary: Titanium and its alloys are commonly used in commercial dental devices. This study investigated the surface morphology and chemical composition of different commercial dental implants through scanning electron microscopy and X-ray photoelectron spectroscopy. The results revealed common features and differences among the implants, as well as the presence of metal oxides on their surfaces.
SURFACE AND INTERFACE ANALYSIS
(2023)
Article
Chemistry, Physical
Alexandru Streza, Aurora Antoniac, Veronica Manescu (Paltanea), Gheorghe Paltanea, Alina Robu, Horatiu Dura, Liliana Verestiuc, Enache Stanica, Stefan Ioan Voicu, Iulian Antoniac, Mihai Bogdan Cristea, Bogdan Radu Dragomir, Julietta V. Rau, Maria-Magdalena Manolea
Summary: Magnesium alloys are promising materials for biodegradable implants due to their ability to promote bone healing and maintain mechanical strength. Surface modification of these alloys using a polymeric-based composite coating with bioactive fillers such as hydroxyapatite and magnesium can reduce biodegradation rate. Various techniques were used to characterize the coatings, and in vitro cytotoxicity assays showed positive effects of magnesium and hydroxyapatite particles for cellulose-acetate-based composite coatings.
Article
Materials Science, Multidisciplinary
Julietta V. Rau, Angela De Bonis, Roberto Teghil, Mariangela Curcio, Inna V. Fadeeva, Katia Barbaro, Massimo Di Menno Di Bucchianico, Marco Fosca, Yufeng Zheng
Summary: In this study, a biodegradable alloy of zinc-lithium (Zn-Li) was coated with a resorbable tricalcium phosphate (Mn,Sr-TCP) doped with manganese and strontium using the Pulsed Laser Deposition method. The coating was characterized using various techniques, and microbiology experiments were performed to test the growth inhibition of bacteria strains and fungus. The results showed that the Mn,Sr-TCP-coated Zn-Li samples exhibited about 10% inhibition on the growth of all four bacteria strains and had the most pronounced effect on Candida albicans fungus (about 50% inhibition of growth). The prepared coatings have the potential to improve the degradation behavior and biological characteristics of Zn-Li alloys.
Article
Materials Science, Ceramics
Amina Gharbi, Hassane Oudadesse, Nureddin Ashammakhi, Wissem Cheikhrouhou-Koubaa, Andreas Blaeser, Julietta V. Rau, Iulian Antoniac, Nabil Derbel, Hafedh El Feki
Summary: This study synthesized bioactive fluorosilicate glasses (BaG-Fx) through melting method to increase the fluoride content in derived Hench bioactive glass (BaG). Different physico-chemical analyses were conducted to characterize the glasses. The addition of calcium fluoride (CaF2) induced significant physico-chemical changes, as proven by X-ray diffraction and infrared spectroscopy. The morphological changes of the glass powders were observed with the increase of CaF2 content, and the thermal analysis demonstrated the impact of fluoride ions on the structural dynamics and thermodynamic properties of the glasses.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Physical
Anna A. Forysenkova, Inna V. Fadeeva, Dina V. Deyneko, Alevtina N. Gosteva, Georgy V. Mamin, Darya V. Shurtakova, Galina A. Davydova, Viktoriya G. Yankova, Iulian V. Antoniac, Julietta V. Rau
Summary: A composite based on polyvinylpyrrolidone (PVP) and alginate (Alg) with carbonate hydroxyapatite (CHA) was prepared and characterized. The microstructure, porosity, and swelling properties of the material were described. In vitro studies demonstrated the biocompatibility of the composite and its potential for dentistry applications.
Article
Chemistry, Physical
Anna A. Forysenkova, Valeria A. Ivanova, Inna V. Fadeeva, Georgy V. Mamin, Julietta V. Rau
Summary: This article investigates the mechanism and properties of the gel formation of alginate with different metal ions using nuclear magnetic resonance spectroscopy. The results show that the concentration of calcium and manganese ions does not affect their distribution in the alginate structure and the cross-linking density, while the number of strontium and copper ions affects the number of binding sites and cross-linking density. Therefore, the cross-linking of alginate is mainly influenced by the characteristics of specific ions, with the nature of the bond being less important.
Article
Polymer Science
Inna V. Fadeeva, Dina V. Deyneko, Alexander V. Knotko, Anatoly A. Olkhov, Pavel V. Slukin, Galina A. Davydova, Taisiia A. Trubitsyna, Ilya I. Preobrazhenskiy, Alevtina N. Gosteva, Iulian V. Antoniac, Julietta V. Rau
Summary: A composite material consisting of electrospinning printed polyhydroxybutyrate fibers impregnated with brushite cement containing Zn substitution was developed for bone implant applications. Characterization of the materials was done using Powder X-ray Diffraction (PXRD), Fourier Transform Infrared Spectroscopy, and Scanning Electron Microscopy. Soaking the composite in Ringer's solution resulted in the transformation of brushite into apatite phase, accompanied by changes in morphology. The bending strength of the composite material was measured to be 3.1 +/- 0.5 MPa. The developed material was found to be non-cytotoxic to NCTC mouse fibroblast cells through the MTT test. The behavior of human dental pulp stem cells on the surface of the composite material was similar to the control.
Review
Engineering, Biomedical
Marco Fosca, Alexandru Streza, Iulian V. Antoniac, Gianluca Vadala, Julietta V. Rau
Summary: Ion-substituted calcium phosphate (CP) coatings have been extensively studied for biomedical implants, showing enhanced biocompatibility, osteoconductivity, and bone formation. This systematic review comprehensively analyzes the effects of ion addition on the physicochemical, mechanical, and biological properties of CP coatings. The review also examines the synergistic effects of different components used with ion-doped CP for composite coatings, and reports on the antibacterial effects of these coatings on specific bacteria strains.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Pharmacology & Pharmacy
Antonio Fabozzi, Marco Barretta, Francesca Della Sala, Gennaro Longobardo, Mario di Gennaro, Teresa Russo, Antonio Gloria, Assunta Borzacchiello
Summary: Natural polymer-based nanoparticles have shown great potential in cancer therapy due to their advantages such as improved drug stability, specific delivery, and reduced toxicity. In this study, non-spherical nanoparticles surface functionalized with hyaluronic acid were compared to their spherical analogs. The results demonstrated that the non-spherical nanoparticles exhibited better cytotoxicity and internalization, which can be attributed to their shape and active targeting ability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Anna A. Forysenkova, Mariya V. Konovalova, Inna V. Fadeeva, Olga S. Antonova, Olga D. Kotsareva, Tatiana K. Slonskaya, Julietta V. Rau, Elena V. Svirshchevskaya
Summary: Surgical operations on the peritoneum often lead to the formation of adhesions. This study evaluated the effectiveness of soluble alginate-polyvinylpyrrolidone (PVP-Alg) and non-soluble Ca ion cross-linked (PVP-Alg-Ca) films in preventing adhesion formation. The results showed that PVP-Alg films effectively prevented adhesions, while PVP-Alg-Ca films caused inflammation and adhesion formation.
Article
Materials Science, Multidisciplinary
Giovana Collombaro Cardoso, Katia Barbaro, Pedro Akira Bazaglia Kuroda, Luca Imperatori, Angela De Bonis, Roberto Teghil, Mariangela Curcio, Elisa Innocenzi, Victoria Yu. Grigorieva, Gianluca Vadala, Carlos Roberto Grandini, Julietta V. Rau
Summary: Micro-arc oxidation (MAO) is a surface modification technique used to improve the surface properties of titanium alloys. This study focused on the surface modification of the β Ti-30Nb-5Mo alloy using MAO method and incorporating calcium, phosphorus, magnesium, and zinc. The results showed that the coating's porosity, roughness, and crystallinity increased with increasing zinc concentration, and the antimicrobial activity was promoted. Incorporating zinc on the surface did not negatively affect cell growth.
Article
Engineering, Biomedical
Amina Gharbi, Hassane Oudadesse, Hafedh el Feki, Wissem Cheikhrouhou-Koubaa, Xanthippi Chatzistavrou, Julietta Rau, Jyrki Heinamaki, Iulian Antoniac, Nureddin Ashammakhi, Nabil Derbel
Summary: In this work, derived Hench bioactive glass containing boron (BaG-B-x) was fabricated using the sol-gel process. A high boron content of 20 wt.% in BaG was achieved for the first time, while maintaining bioactivity and biodegradability. The BaG-B-x showed enhanced bioactivity and chemical stability, with improved crystallization rate and quality of the newly formed hydroxyapatite (HAp) layer on the surface. The presence of boron also accelerated the degradation of BaGs in simulated body fluid (SBF). Therefore, BaG-B-x can be a potential material for bone regeneration, especially in children.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Engineering, Multidisciplinary
Alexandru Streza, Aurora Antoniac, Veronica Manescu (Paltanea), Robert Ciocoiu, Cosmin-Mihai Cotrut, Marian Miculescu, Florin Miculescu, Iulian Antoniac, Marco Fosca, Julietta V. Rau, Horatiu Dura
Summary: Magnesium alloys are suitable materials for orthopedic and maxillofacial implants due to their biocompatibility and good mechanical properties. However, their high-speed corrosion and hydrogen release are major drawbacks. This study investigates the use of alloying elements and coatings to improve the corrosion and mechanical properties of magnesium alloys. The results show that the composite coating based on cellulose acetate and hydroxyapatite particles exhibits the best protective effect for magnesium alloys.
Article
Polymer Science
Alina Petrova, Georgy Mamin, Oleg Gnezdilov, Inna Fadeeva, Olga Antonova, Anna Forysenkova, Iulian V. Antoniac, Julietta V. Rau, Marat Gafurov
Summary: The study synthesized biocompatible and bioresorbable polymer matrix-mineral composite materials and investigated their properties using electron paramagnetic resonance and nuclear magnetic resonance. The results demonstrated that magnetic resonance methods can be used for quality control and monitoring of the treatment, resorption, and degradation processes of the composites.
