Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice

Required growth facilitators propel axon regeneration across complete spinal cord injury

(2018) Mark A. Anderson et al.   NATURE

Combined chondroitinase and KLF7 expression reduce net retraction of sensory and CST axons from sites of spinal injury

(2017) Zimei Wang et al.   NEUROBIOLOGY OF DISEASE

AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors

(2017) Brian Zingg et al.   NEURON

Boosting CNS axon regeneration by harnessing antagonistic effects of GSK3 activity

(2017) Marco Leibinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cortical projections to the red nucleus and the brain stem in the rhesus monkey

(2016) Roger N. Lemon   BRAIN RESEARCH

Hyper-IL-6: a potent and efficacious stimulator of RGC regeneration

(2016) D Fischer   EYE

Promotion of Functional Nerve Regeneration by Inhibition of Microtubule Detyrosination

(2016) P. Gobrecht et al.   JOURNAL OF NEUROSCIENCE

Boosting Central Nervous System Axon Regeneration by Circumventing Limitations of Natural Cytokine Signaling

(2016) Marco Leibinger et al.   MOLECULAR THERAPY

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

Comparative three-dimensional connectome map of motor cortical projections in the mouse brain

(2016) Minju Jeong et al.   Scientific Reports

Highly efficient transduction of primary adult CNS and PNS neurons

(2016) Evgeny Levin et al.   Scientific Reports

Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice

(2015) Camelia A. Danilov et al.   EXPERIMENTAL NEUROLOGY

Trans-neuronal transduction of spinal neurons following cortical injection and anterograde axonal transport of a bicistronic AAV1 vector

(2015) T H Hutson et al.   GENE THERAPY

Toll-Like Receptors and Dectin-1, a C-Type Lectin Receptor, Trigger Divergent Functions in CNS Macrophages

(2015) J. C. Gensel et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion Promotes Regrowth of Corticospinal Tract Axons 1 Year after Spinal Cord Injury

(2015) K. Du et al.   JOURNAL OF NEUROSCIENCE

Plasticity of Intact Rubral Projections Mediates Spontaneous Recovery of Function after Corticospinal Tract Injury

(2015) C. S. Siegel et al.   JOURNAL OF NEUROSCIENCE

Effects of PTEN and Nogo Codeletion on Corticospinal Axon Sprouting and Regeneration in Mice

(2015) C. G. Geoffroy et al.   JOURNAL OF NEUROSCIENCE

A motor cortex circuit for motor planning and movement

(2015) Nuo Li et al.   NATURE

Restoration of skilled locomotion by sprouting corticospinal axons induced by co-deletion of PTEN and SOCS3

(2015) Duo Jin et al.   Nature Communications

The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury

(2014) Yosuke Ohtake et al.   BIOMATERIALS

Signaling regulations of neuronal regenerative ability

(2014) Yi Lu et al.   CURRENT OPINION IN NEUROBIOLOGY

AAVshRNA-Mediated Suppression of PTEN in Adult Rats in Combination with Salmon Fibrin Administration Enables Regenerative Growth of Corticospinal Axons and Enhances Recovery of Voluntary Motor Function after Cervical Spinal Cord Injury

(2014) G. Lewandowski et al.   JOURNAL OF NEUROSCIENCE

Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury

(2014) Bradley T. Lang et al.   NATURE

Sustained GSK3 activity markedly facilitates nerve regeneration

(2014) Philipp Gobrecht et al.   Nature Communications

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

(2013) K. Zukor et al.   JOURNAL OF NEUROSCIENCE

Characterization of a Cervical Spinal Cord Hemicontusion Injury in Mice Using the Infinite Horizon Impactor

(2013) Femke Streijger et al.   JOURNAL OF NEUROTRAUMA

Misguidance and modulation of axonal regeneration by Stat3 and Rho/ROCK signaling in the transparent optic nerve

(2013) V Pernet et al.   Cell Death & Disease

Interleukin-6 contributes to CNS axon regeneration upon inflammatory stimulation

(2013) M Leibinger et al.   Cell Death & Disease

Neuronal STAT3 activation is essential for CNTF- and inflammatory stimulation-induced CNS axon regeneration

(2013) M Leibinger et al.   Cell Death & Disease

p53 Regulates the Neuronal Intrinsic and Extrinsic Responses Affecting the Recovery of Motor Function following Spinal Cord Injury

(2012) E. M. Floriddia et al.   JOURNAL OF NEUROSCIENCE

Promoting optic nerve regeneration

(2012) Dietmar Fischer et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

(2011) Fang Sun et al.   NATURE

PTEN/mTOR and axon regeneration

(2010) Kevin K. Park et al.   EXPERIMENTAL NEUROLOGY

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Assessing Spinal Axon Regeneration and Sprouting in Nogo-, MAG-, and OMgp-Deficient Mice

(2010) Jae K. Lee et al.   NEURON

Interleukin-6 and the serotonergic system of the medulla oblongata in the sudden infant death syndrome

(2009) Ingvar Jon Rognum et al.   ACTA NEUROPATHOLOGICA

Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons

(2009) Kevin J. Cummings et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Acute rolipram/thalidomide treatment improves tissue sparing and locomotion after experimental spinal cord injury

(2009) Guido C. Koopmans et al.   EXPERIMENTAL NEUROLOGY

Neuroprotective and Axon Growth-Promoting Effects following Inflammatory Stimulation on Mature Retinal Ganglion Cells in Mice Depend on Ciliary Neurotrophic Factor and Leukemia Inhibitory Factor

(2009) M. Leibinger et al.   JOURNAL OF NEUROSCIENCE

Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation

(2009) Guillermo García-Alías et al.   NATURE NEUROSCIENCE

SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

(2009) Patrice D. Smith et al.   NEURON

5,7-Dihydroxitryptamine toxicity to serotonergic neurons in serum free raphe cultures

(2008) João Paulo Capela et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

IGF-I gene delivery promotes corticospinal neuronal survival but not regeneration after adult CNS injury

(2008) Edmund R. Hollis et al.   EXPERIMENTAL NEUROLOGY

Repulsive Wnt Signaling Inhibits Axon Regeneration after CNS Injury

(2008) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

A Graded Forceps Crush Spinal Cord Injury Model in Mice

(2008) Jason R. Plemel et al.   JOURNAL OF NEUROTRAUMA

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE