Article
Medicine, Research & Experimental
Yi Wang, Yuqiu Li, Junpei Zhong, Miao Li, Youjia Zhou, Qing Lin, Siwen Zong, Wenting Luo, Jiayang Wang, Keqin Wang, Jie Wang, Lixia Xiong
Summary: Cav-1 in exosomes derived from breast cancer cells promotes lung metastasis by regulating intercellular communication and PMN formation.
Article
Engineering, Biomedical
Xiaoqing Han, Xingbo Wang, Jiao Yan, Panpan Song, Yanjing Wang, Chao Shang, Yunyun Wu, Hua Zhang, Zhenxin Wang, Haiyuan Zhang, Xi Li
Summary: Premetastatic niche (PMN) is crucial for tumor metastasis and its destruction can effectively suppress tumor metastasis. Neutrophils, as therapeutic agents, can migrate to inflammatory sites and consume tumor-derived secreted factors, thus inhibiting PMN formation and metastasis.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Maximilian Geissler, Weiyi Jia, Emine Nisanur Kiraz, Ida Kulacz, Xiao Liu, Adrian Rombach, Vincent Prinz, Daniel Jussen, Konstantinos D. Kokkaliaris, Hind Medyouf, Lisa Sevenich, Marcus Czabanka, Thomas Broggini
Summary: Metastasis, especially brain metastasis, is still a mystery to researchers, and studying its molecular basis may lead to breakthroughs in combating this lethal cancer. The focus of recent research has shifted to understanding the early steps of metastasis formation, including how the primary tumor influences distant organ sites before tumor cells arrive. The concept of pre-metastatic niche encompasses various factors that affect future metastasis sites, such as immunological modulation and ECM remodeling. Although the mechanisms of brain metastasis are still elusive, studying the earliest steps in metastasis formation provides insights into these processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shuxia Zhang, Xinyi Liao, Suwen Chen, Wanying Qian, Man Li, Yingru Xu, Meisongzhu Yang, Xincheng Li, Shuang Mo, Miaoling Tang, Xingui Wu, Yameng Hu, Ziwen Li, Ruyuan Yu, Ainiwaerjiang Abudourousuli, Libing Song, Jun Li
Summary: Tumor-derived extracellular vesicles play critical roles in generating a pre-metastatic microenvironment for organotropic metastasis. This study discovers the crucial role of large oncosomes in bone-tropic metastasis of hepatocellular carcinoma by engineering an osteoclastic pre-metastatic niche. The interaction between VAMP-associated protein A on large oncosomes and osteoclasts mediates the formation of the microenvironment and contributes to HCC bone metastasis.
Review
Biochemistry & Molecular Biology
Lionel Gillot, Louis Baudin, Loic Rouaud, Frederic Kridelka, Agnes Noel
Summary: Lymph node metastasis is a significant prognostic factor in various cancers, serving as a gateway for further dissemination. Prior to metastasis, the primary tumor reshapes the draining lymph node by secreting soluble factors or releasing extracellular vesicles, creating a pre-metastatic niche for the survival and growth of metastatic cells. This review highlights the structure of lymph nodes, matrix composition, cellular heterogeneity, and major processes associated with nodal pre-metastatic niche formation, offering insights into potential research directions and clinical implications.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Benjamin Ormseth, Amblessed Onuma, Hongji Zhang, Allan Tsung
Summary: The pre-metastatic niche (PMN) is a targeted therapy that prevents cancer metastasis before it occurs. The communication between primary tumors and the liver establishes a microenvironment that increases susceptibility to tumor cell invasion and outgrowth. Understanding the mechanisms of the PMN could provide opportunities for clinical intervention and potentially serve as biomarkers.
Review
Oncology
Jing Gao, Song Li, Qian Xu, Xue Zhang, Miao Huang, Xin Dai, Lian Liu
Summary: Exosomes play a crucial role in the formation of pre-metastatic niches in gastric cancer, facilitating tumor metastasis by establishing a supportive environment remotely. The cell components in pre-metastatic niches secrete exosomes that interact with each other, providing signals that promote tumor growth.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Shumei Tu, Dengxuan Mao, Mengxin Shi, Huangqin Zhang, Congyan Liu, Xiaoqi Li, Yang Zhao, Yan Chen, Yuping Liu
Summary: The concept of the inflammatory pre-metastatic niche provides a new direction for preventing and treating metastasis. In this study, ICT was found to inhibit the pulmonary metastasis of melanoma cells by interfering with the PMN. It also suppressed the generation of pro-inflammatory PMN by inactivating the STING signaling pathway. These findings highlight a new binding mechanism between STING and ICT for the inhibition of the STING signaling pathway.
PHYTOTHERAPY RESEARCH
(2022)
Article
Hematology
Harvey G. Roweth
Summary: In addition to their traditional roles in blood clotting and hemostasis, platelets are also involved in nonhemostatic pathologies, including tumor cell metastasis. Mechanistic studies have shown that platelets bind directly to tumor cells in blood vessels, promoting key features of metastasis such as survival in the bloodstream and tumor cell arrest at secondary sites. Furthermore, platelets also interact with nonmalignant cells in primary and metastatic tumors, creating microenvironments that support successful tumor cell metastasis.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Review
Pharmacology & Pharmacy
Yuping Liu, Dengxuan Mao, Hong Wang, Xiaoyu Che, Yan Chen
Summary: Tumor cells-derived EVs play a crucial role in the formation of PMN in the lung and can potentially be utilized as a target or carrier for the intervention of lung PMN.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Chemistry, Multidisciplinary
Yongchao Chu, Tao Sun, Chen Jiang
Summary: The emergence of disseminated metastasis is the leading cause of mortality in patients with malignant tumors. Targeting the pre-metastatic microenvironment may be a promising strategy for preventing metastasis. Nanosystems have shown strong potential in anti-metastatic therapy by selectively targeting pre-metastatic microenvironments.
CHINESE CHEMICAL LETTERS
(2022)
Article
Medicine, Research & Experimental
Xinxin Yuan, Niansong Qian, Shukuan Ling, Yuheng Li, Weijia Sun, Jianwei Li, Ruikai Du, Guohui Zhong, Caizhi Liu, Guotao Yu, Dengchao Cao, Zizhong Liu, Yinbo Wang, Zhihong Qi, Yingpeng Yao, Fang Wang, Jingjing Liu, Shanshan Hao, Xiaoyan Jin, Yinlong Zhao, Jianqi Xue, Dingsheng Zhao, Xingcheng Gao, Shuai Liang, Youyou Li, Jinping Song, Shuyang Yu, Yingxian Li
Summary: Exosomes derived from breast cancer cells, particularly SCP28 cells, play a crucial role in promoting osteoclast differentiation and activation, contributing to the accelerated formation of a microenvironment favorable for bone metastasis. Specifically, the exosomal miR-21 from SCP28 cells regulates PDCD4 protein levels to facilitate osteoclastogenesis, indicating its potential as a diagnostic and therapeutic target for breast cancer bone metastasis.
Article
Biochemistry & Molecular Biology
Katsuaki Ieguchi, Masabumi Funakoshi, Taishi Mishima, Kohtaro Takizawa, Tsutomu Omori, Fumio Nakamura, Makoto Watanabe, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Yoshiro Maru, Satoshi Wada
Summary: Emerging evidence suggests that neural activity contributes to tumor initiation and metastasis. Specifically, the sympathetic nervous system has been found to regulate tumor angiogenesis, growth, and metastasis. By performing chemical sympathectomy, researchers observed a decrease in lung metastasis and identified neuro-immune cell interactions in tumor-bearing mouse lungs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Xiaoxiao Chen, Jiamei Feng, Weili Chen, Shijun Shao, Li Chen, Hua Wan
Summary: Breast cancer metastasis is a complex process, and breast cancer-derived small extracellular vesicles (sEVs) play a crucial role in the formation of pre-metastatic niches. sEVs contribute to tumor invasion through various mechanisms and can also be used as biomarkers and antimetastatic therapies for breast cancer.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biotechnology & Applied Microbiology
Hanwen Zheng, Chunsen Yuan, Jiajun Cai, Wendan Pu, Peng Wu, Chenwen Li, Gang Li, Yang Zhang, Jianxiang Zhang, Jiawei Guo, Dingde Huang
Summary: The luminescent nanoparticles (LAD NPs) based on neutrophil-targeting imaging strategy can serve as a promising modality for early diagnosis of lung metastasis of breast cancers. The targeting nanoprobe shows enhanced luminescence imaging capability and outperforms PET/CT imaging modalities in detecting pulmonary metastasis.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Clinical Neurology
Beddome C. Allen, Sahil Kapoor, Anthony Anzalone, Kirby P. Mayer, Stacey Q. Wolfe, Pam Duncan, Andrew W. Asimos, Ralph D'Agostino Jr, James Tripp Winslow, Aarti Sarwal
Summary: This study reviewed the feasibility of transcranial ultrasonography (TCU) as a diagnostic tool for evaluating intracranial pathology in critical care or austere settings. The results showed that TCU has reasonable sensitivity and specificity in detecting intracranial pathology including intracranial hemorrhage and tumors. This suggests that TCU can be clinically valuable in remote areas or where standard imaging is unavailable.
JOURNAL OF NEUROIMAGING
(2023)
Editorial Material
Oncology
Ravindra P. Deshpande
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2023)
Correction
Multidisciplinary Sciences
Dan Zhao, Kerui Wu, Sambad Sharma, Fei Xing, Shih-Ying Wu, Abhishek Tyagi, Ravindra Deshpande, Ravi Singh, Martin Wabitsch, Yin-Yuan Mo, Kounosuke Watabe
NATURE COMMUNICATIONS
(2023)
Article
Health Care Sciences & Services
Annika Hoyer, Ralph Brinks, Thaddaeus Toennies, Sharon H. Saydah, Ralph B. D'Agostino Jr, Jasmin Divers, Scott Isom, Dana Dabelea, Jean M. Lawrence, Elizabeth J. Mayer-Davis, Catherine Pihoker, Lawrence Dolan, Giuseppina Imperatore
Summary: This study aimed to examine whether a partial differential equation (PDE) can be used to estimate the incidence of diabetes from prevalence. The results showed that the PDE method can accurately estimate the incidence rates of diabetes, and it has the advantage of cost savings compared to traditional methods.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Review
Oncology
Ryan T. Hughes, Rediet R. Gebeyehu, John Mason Kalada, Thomas W. Lycan, Bart A. Frizzell, Rebecca D. Kinney, Ralph B. D'Agostino, Paul M. Bunch, Pierre Triozzi, Wei Zhang, Cristina M. Furdui, Mercedes Porosnicu
Summary: Effective treatment options for advanced/recurrent head and neck squamous-cell carcinoma are limited. The combination of the immune checkpoint inhibitor pembrolizumab and quad-shot, a hypofractionated palliative radiotherapy regimen, shows promise as a potential treatment strategy. This study aims to evaluate the response rates, survival outcomes, and treatment toxicity of this combined therapy, as well as identify molecular biomarkers and immune-related impacts using correlative multiomics analysis.
Article
Clinical Neurology
Christine Henry, Sahil Kapoor, Vivek Krishnan, John Levi, Kyle Fargen, Ralph D'Agostino, Sheryl Hendrix, Dana Foster, Patrick Brown, Charles A. Tegeler, Aarti Sarwal
Summary: This study used transcranial color-coded duplex (TCCD) to examine the transverse venous sinus (TVS), establish normative values, analyze physiological variability, and explore the validity of using TCCD to diagnose transverse venous sinus stenosis (TVSS).
JOURNAL OF NEUROIMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Katherine A. A. Sauder, Deborah H. H. Glueck, Kylie K. K. Harrall, Ralph D'Agostino, Lawrence M. M. Dolan, Abbi D. D. Lane, Angela D. D. Liese, Eva Lustigova, Faisal S. S. Malik, Santica Marcovina, Elizabeth Mayer-Davis, Amy Mottl, Catherine Pihoker, Kristi Reynolds, Amy S. S. Shah, Elaine M. M. Urbina, Lynne E. E. Wagenknecht, Stephen R. R. Daniels, Dana Dabelea
Summary: This study examined arterial stiffness in individuals with type 1 diabetes and explored the differences between Hispanic, non-Hispanic Black, and non-Hispanic White individuals. The results showed that cardiovascular and socioeconomic factors explain a quarter of the racial and ethnic differences in arterial stiffness, but non-Hispanic Black individuals still experienced higher arterial stiffness.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Kerui Wu, Feng Lyu, Shih-Ying Wu, Sambad Sharma, Ravindra Pramod Deshpande, Abhishek Tyagi, Dan Zhao, Fei Xing, Ravi Singh, Kounosuke Watabe
Summary: An active immunotherapy using a smart nanovesicle has been developed to overcome the resistance of breast cancer to immunotherapies. The nanovesicle, called IL2-ep13nsEV, carries bioactive interleukin 2 (IL2) and T cell-promoting costimulatory factors on its surface, allowing for personalized treatment. It also presents antigens inherited from tumor lysate-pulsed dendritic cells and performs antigen presentation. In experiments, IL2-ep13nsEV induced a strong immune reaction, sensitized cancer cells to immune checkpoint inhibitors, and prevented tumor recurrence.
Article
Oncology
Yin Liu, Margaret R. R. Smith, Yuezhu Wang, Ralph D'Agostino Jr, Jimmy Ruiz, Thomas Lycan, Gregory L. L. Kucera, Lance D. D. Miller, Wencheng Li, Michael D. D. Chan, Michael Farris, Jing Su, Qianqian Song, Dawen Zhao, Arvind Chandrasekaran, Fei Xing
Summary: This study reveals that tumor-infiltrating neutrophils secrete high levels of lipocalin 2 (LCN2), which enhances the stemness of tumor cells in brain metastasis. The interactions between neutrophils and brain metastatic cells provide new insights into treating brain metastasis.
Article
Oncology
Margaret R. Smith, Yuezhu Wang, Ralph D'Agostino, Yin Liu, Jimmy Ruiz, Thomas Lycan, George Oliver, Lance D. Miller, Umit Topaloglu, Jireh Pinkney, Mohammed N. Abdulhaleem, Michael D. Chan, Michael Farris, Jing Su, Kathryn F. Mileham, Fei Xing
Summary: Different therapy options are used for NSCLC based on tumor stage and genetic mutations. However, biomarkers to guide treatment selection are limited. A study collected clinical and sequencing data from 524 NSCLC patients to examine the association between mutation profiles and treatment response. Mutation composite scores (MCS) were generated for different treatments, and MCS showed superior predictive power compared to other biomarkers in immune therapy-treated patients.
NPJ PRECISION ONCOLOGY
(2023)
Editorial Material
Oncology
Abhishek Tyagi
FRONTIERS IN ONCOLOGY
(2023)
Article
Biology
Qianqian Song, Jimmy Ruiz, Fei Xing, Hui-Wen Lo, Lou Craddock, Ashok K. K. Pullikuth, Lance D. D. Miller, Michael H. H. Soike, Stacey S. S. O'Neill, Kounosuke Watabe, Michael D. D. Chan, Jing Su
Summary: Single-cell transcriptomic analysis reveals the crucial role of fibroblasts in remodeling tumor microenvironments through the type I collagen signaling axis. Brain metastases are a common intracranial tumor, accounting for about 20% of all systematic cancer cases. Identifying biomarkers and understanding cellular interactions in the tumor microenvironment is essential for effective surveillance and treatment of brain metastases.
COMMUNICATIONS BIOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Warren Szewczyk, Kerryn Reding, Richard Kar-Hang Cheng, Laura Johnson, Oxana Palesh, Alexi Vasbinder, Amy Ladd, Ralph Dagostino, Kathryn Weaver, Glenn J. Lesser, W. Gregory Hundley
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Meeting Abstract
Endocrinology & Metabolism
Kelsey B. Eitel, Alissa J. Roberts, Ralph D'Agostino, Catherine E. Barrett, Ronny A. Bell, Anna Bellatorre, Angelica Cristello, Dana Dabelea, Lawrence M. Dolan, Elizabeth T. Jensen, Angela D. Liese, Elizabeth J. Mayer-Davis, Kristi Reynolds, Santica M. Marcovina, Catherine Pihoker
HORMONE RESEARCH IN PAEDIATRICS
(2023)