Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer

Autophagy regulates trophoblast invasion by targeting NF-κB activity

(2020) Soo-young Oh et al.   Scientific Reports

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

(2019) Askar Yimit et al.   Nature Communications

SPSB1 enhances ovarian cancer cell survival by destabilizing p21

(2019) Hyun-Jung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autophagy and senescence: A new insight in selected human diseases

(2019) Peramaiyan Rajendran et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

(2018) Mario Mauthe et al.   Autophagy

Use of Targeted Therapeutics in Epithelial Ovarian Cancer: A Review of Current Literature and Future Directions

(2018) Monica Hagan Vetter et al.   CLINICAL THERAPEUTICS

Autophagy inhibition improves the chemotherapeutic efficacy of cruciferous vegetable-derived diindolymethane in a murine prostate cancer xenograft model

(2018) Hossam Draz et al.   INVESTIGATIONAL NEW DRUGS

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

AZD6738, A Novel Oral Inhibitor of ATR, Induces Synthetic Lethality with ATM Deficiency in Gastric Cancer Cells

(2017) Ahrum Min et al.   MOLECULAR CANCER THERAPEUTICS

Patient-Derived Xenograft Models of Epithelial Ovarian Cancer for Preclinical Studies

(2017) Eun Jin Heo et al.   Cancer Research and Treatment

Autophagy inhibitor chloroquine increases sensitivity to cisplatin in QBC939 cholangiocarcinoma cells by mitochondrial ROS

(2017) Xianzhi Qu et al.   PLoS One

The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair

(2016) Diana H. Liang et al.   CANCER LETTERS

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme

(2016) Zachary D. Nagel et al.   CANCER RESEARCH

Sequential combination therapy of ovarian cancer with cisplatin and γ-secretase inhibitor MK-0752

(2016) XiuXiu Chen et al.   GYNECOLOGIC ONCOLOGY

The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect

(2015) Tingting Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells

(2014) Feng-Ze Wang et al.   APOPTOSIS

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The emerging role of the Nrf2-Keap1 signaling pathway in cancer

(2013) M. C. Jaramillo et al.   GENES & DEVELOPMENT

Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer

(2013) M. A. Batey et al.   MOLECULAR CANCER THERAPEUTICS

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy

(2011) Natura Myeku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells

(2011) E. L. Kim et al.   NEURO-ONCOLOGY

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA

Therapeutic Targeting of ATP7B in Ovarian Carcinoma

(2009) L. S. Mangala et al.   CLINICAL CANCER RESEARCH

Inhibition of lysosomal functions reduces proteasomal activity

(2009) Liyan Qiao et al.   NEUROSCIENCE LETTERS

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

DNA Damage Detection and Repair Pathways--Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy

(2008) S. Ashwell et al.   CLINICAL CANCER RESEARCH