Article
Chemistry, Multidisciplinary
Fuhu Guo, Shiquan Shan, Xu Gong, Cancan Dai, Zhengjun Quan, Xiamin Cheng, Xinyuan Fan
Summary: We propose a novel and effective photocatalytic method for the methylation of & beta;-diketones with controllable degrees of deuterium incorporation by developing new methyl sources. By utilizing a methylamine-water system and a cascade assembly strategy, we synthesized methylated compounds with varying degrees of deuterium incorporation. This work demonstrates the utility of readily available reagents, methylamines and water, as a new methyl source, and provides a simple and efficient strategy for the synthesis of degree-controllable deuterium-labelled compounds.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Kazuho Ban, Keisuke Imai, Shuki Oyama, Jin Tokunaga, Yui Ikeda, Hiromasa Uchiyama, Kazunori Kadota, Yuichi Tozuka, Shuji Akai, Yoshinari Sawama
Summary: In this study, a novel concept for preparing deuterated reagents was established and the deuterium kinetic isotope effects were demonstrated for the first time. This research has significant implications for drug discovery based on deuterium chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Food Science & Technology
Ryan M. Parente, Paul M. Tarantino, Bradford C. Sippy, George A. Burdock
Summary: Deuteration as a means of altering caffeine's effects and duration of activity is unexplored. d9-Caffeine, a deuterated isotopologue of caffeine, may offer an alternative with less frequent consumption, lower doses, and reduced exposure to caffeine metabolites. Characterization of d9-caffeine's genotoxic potential and pharmacokinetic behavior is critical in understanding its differences from caffeine.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Organic
Fei-Fei Sheng, Jian-Guo Gu, Kai-Hui Liu, Hong-Hai Zhang
Summary: This study presents a highly efficient and easily manipulated palladium-catalyzed H/D exchange protocol for the synthesis of beta-deuterated N-protected amino amides, which can be converted to beta-deuterated amino acids by removing protecting groups. The use of pivalic acid as an additive also promoted the successful deuterium labeling of phenylalanine derivatives.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Mengjia Yuan, Fuyin Ma, Xing Dai, Lixi Chen, Fuwan Zhai, Linwei He, Mingxing Zhang, Junchang Chen, Jie Shu, Xiaomei Wang, Xia Wang, Yugang Zhang, Xiaobin Fu, Zhenyu Li, Chenglong Guo, Long Chen, Zhifang Chai, Shuao Wang
Summary: By introducing the isotope effect, the luminescence performance of COFs has been significantly improved. The deuterated COF achieved an impressive 19-fold enhancement in quantum yield compared to the non-deuterated counterpart. This strategy is proven to be applicable to many other types of emissive COFs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Chunyang Hu, Fangming Chen, Guo-Ping Lu, Wen-Bin Yi
Summary: A new, stable, and scalable reagent, PhthSCF(2)D, has been developed for deuteriodifluoromethylthiolation, which can be applied in both photocatalytic radical and electrophilic reactions.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Xiang-Ting Min, Yong-Kang Mei, Bing-Zhi Chen, Li-Bowen He, Ting-Ting Song, Ding-Wei Ji, Yan-Cheng Hu, Boshun Wan, Qing-An Chen
Summary: An efficient deuterium labeling technique using Rh-catalyzed decarbonylation of aldehydes with D2O is developed, which shows great potential in the field of deuterated drug candidates.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Wei Ou, Xudong Xiang, Ru Zou, Qing Xu, Kian Ping Loh, Chenliang Su
Summary: This method involves the palladium-catalyzed introduction of deuterium into carbon-oxygen bonds in alcohols and ketones using D-2 balloon at room temperature, showcasing a practical synthesis of deuterated pharmaceuticals and chemicals. Its advantages include mild conditions, broad scope, and high chemoselectivity. By utilizing electrocatalytic D2O-splitting, D-2 can be supplied on demand, enabling precise incorporation of deuterium in pharmaceuticals in a sustainable and practical way.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Siyu Chang, Jun Bu, Jinjin Li, Jin Lin, Zhenpeng Liu, Wenxiu Ma, Jian Zhang
Summary: Herein, we propose an electrocatalytic deuteration strategy for continuous production of deuterated ethylene from acetylene under ambient conditions, utilizing D2O as the D source. Ag nanoparticles exhibit a high deuterated ethylene Faradic efficiency of 99.3% at -0.6 V vs. reversible hydrogen electrode. Additionally, Ag nanoparticles achieve a deuterated ethylene production rate of 3.72 x 10 3 mmol h-1 gcat-1 and show excellent long-term stability.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Zoua Pa Vang, Samuel J. Hintzsche, Joseph R. Clark
Summary: This article discusses the recent advances in catalytic transfer deuteration and transfer hydrodeuteration, as well as methods for the selective synthesis of deuterated alkanes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Optics
Carla Tenorio, Sylvain Bernes, Diego Solis-Ibarra, Efren Gonzalez-Monfil, Paulina Carmona-Monroy, Laura Gasque
Summary: This study describes six new eight-coordinate samarium complexes, consisting of a coumarin derived chelating ligand with or without a diimine auxiliary ligand (1,10-phenanthroline or 4,7-diphenyl-1,10-phenanthroline). The crystal structure and luminescent properties of two complexes are presented. It was found that partial deuteration of the coumarin ligand had a significant effect on the solid state QY values.
JOURNAL OF LUMINESCENCE
(2023)
Article
Chemistry, Organic
Chun-Hong Hu, Yang Li
Summary: A metal-free synthesis of C1-deuterated aldehydes was developed, which utilizes D2O and alpha-oxo carboxylic acids at ambient temperature. This method avoids the use of stoichiometric reductants and oxidants, and can tolerate various functional groups, resulting in high yields and high deuteration levels.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Marta Pytlarczyk, Kornelia Gaczol, Piotr Harmata, Jerzy Dziaduszek, Jakub Herman
Summary: In this study, three synthetic methods for 2,20,4-trifluoro-4 ''-alkyl-[1,1 ':4 ',1 '']terphenyls were presented, with fluorination at the inner-core position found to promote only a nematic phase. The synthesis and purity of the compounds were monitored using gas chromatography and thermal analysis techniques, with phase situations and transition temperatures determined.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Marta Pytlarczyk, Jakub Herman, Yuki Arakawa, Hideto Tsuji, Przemyslaw Kula
Summary: Liquid crystals, especially those with high birefringence, are crucial in optoelectronic devices, but their lifetime is affected by photodegradation processes. New reinforced molecules and deuterated liquid crystals show higher photochemical stability and isotopic purity, indicating potential for widespread use in various liquid crystal devices.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Organic
Yonghang Mu, Zi Wang, Linhua Song, Kun Ma, Yao Chen, Peixun Li, Zifeng Yan
Summary: This article reports a gram-scale synthesis of chain-deuterated sphingosines using hydrothermal platinum-catalyzed hydrogen/deuterium (H/D) exchange and Horner-Wadsworth-Emmons coupling. The deuterium content of the synthesized products was characterized using H-1 NMR and high-resolution mass spectrum (HRMS).
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Spectroscopy
Zheng Li, Yanqi Xu, Huandi Xu, Mengyuan Cui, Tianguang Liu, Xiangyu Ren, Jianfei Sun, Dawei Deng, Yueqing Gu, Peng Wang
Summary: A novel near-infrared fluorescence probe DCM-Cu was designed for the detection of Cu2+, showing good sensitivity and selectivity towards Cu2+. The probe was successfully applied in detecting Cu2+ in living cells and tumor tissue with low cytotoxicity, indicating its potential for monitoring cellular Cu2+ and disease diagnosis.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Chen Ling, Mengyuan Cui, Jieru Chen, Lili Xia, Dawei Deng, Yueqing Gu, Peng Wang
Review
Chemistry, Analytical
Haonan Li, Yuxi Fang, Junjie Yan, Xiangyu Ren, Chao Zheng, Bo Wu, Siyuan Wang, Zhanlin Li, Huiming Hua, Peng Wang, Dahong Li
Summary: Hydrogen sulfide (H2S) is considered as another gasotransmitter involved in important physiological and pathological processes. To real-time detect H2S in biological systems, numerous small-molecule fluorescent probes have been developed, with improvements in selectivity, response capability, and optical performance.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Inorganic & Nuclear
Xiangyu Ren, Yuxin Han, Yanqi Xu, Tianguang Liu, Mengyuan Cui, Lili Xia, Haonan Li, Yueqing Gu, Peng Wang
Summary: NMOFs have been widely used in cancer therapy due to their advantages, including better long-term biodegradability and lower toxicity to normal tissue. Diversified strategies based on metal-organic frameworks, such as PDT, PTT, and CDT, have effectively been applied in cancer treatment.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Spectroscopy
Chen Ling, Tianguang Liu, Ruhui Li, Shihao Wang, Jinyang Zhang, Shuaiwen Li, Lili Xia, Mengyuan Cui, Peng Wang
Summary: Ozone is widely used in industry and medical therapies, but overexposure can lead to health issues. The fluorescent probe DCM-O-3, developed for detecting ozone, shows high selectivity and sensitivity, as well as low cytotoxicity in live cells.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Wei Wang, Min Ji, Junqing Chen, Peng Wang
Summary: In this study, a turn-on type aggregation-induced emission (AIE) fluorescent probe BQM-NBD was developed for selective detection of Cys and Hcy in organisms, showing good selectivity. Additionally, BQM-NBD exhibited low cytotoxicity when used for imaging Cys in living cells.
Article
Chemistry, Analytical
Jing Yang, Weihua Ding, Biyue Zhu, Sherri Zhen, Shi Kuang, Jun Yang, Can Zhang, Peng Wang, Fan Yang, Liuyue Yang, Wei Yin, Rudolph E. Tanzi, Shiqian Shen, Chongzhao Ran
Summary: Bioluminescence imaging can be used to monitor the levels of amyloid beta in Alzheimer's disease and serve as a reservoir mechanism for functional amyloids. The feasibility of this method has been validated through in vitro and in vivo experiments, and it can also be used to monitor disease progression and therapeutic effectiveness.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Huizhe Wang, Xiaohui Xiong, Jiaqi Zhang, Meicen Wu, Yinhui Gu, Yanli Chen, Yueqing Gu, Peng Wang
Summary: This study found that CycNHOH NPs and CypNHOH NPs can activate innate immunity by accelerating the DNA damage process through phototherapy and releasing immunogenic cell death, providing a new direction for the development of photo-immunotherapy.
Article
Chemistry, Organic
Min Yang, Lili Xia, Xiaoqin Zhou, Chengli Jia, Min Ji, Peng Wang
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Xiaoqin Zhou, Mengyuan Cui, Chengli Jia, Min Yang, Min Ji, Peng Wang
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Materials Science, Biomaterials
Wancun Zhang, Lili Xia, Xiangyu Ren, Mengyuan Cui, Tianguang Liu, Chen Ling, Yanqi Xu, Dawei Deng, Xianwei Zhang, Yueqing Gu, Peng Wang
BIOMATERIALS SCIENCE
(2020)
Article
Chemistry, Multidisciplinary
Mengyuan Cui, Haonan Li, Kangyu Ren, Lili Xia, Dawei Deng, Yueqing Gu, Dahong Li, Peng Wang
Article
Chemistry, Multidisciplinary
Jing Yang, Biyue Zhu, Wei Yin, Zhihao Han, Chao Zheng, Peng Wang, Chongzhao Ran
Article
Chemistry, Multidisciplinary
Mengyuan Cui, Lili Xia, Yueqing Gu, Peng Wang
NEW JOURNAL OF CHEMISTRY
(2020)
