Article
Rheumatology
Yevgeniya Gartshteyn, John Conklin, Michelle A. Petri, Vasileios C. Kyttaris, Daniel W. Goldman, Anja Kammesheidt, Anca D. Askanase, Roberta Vezza Alexander
Summary: The study found that PC4d levels in SLE patients are correlated with history of thrombosis and can assess the risk of future thrombosis events. Patients with a PC4d level above the cutoff of 13 MFI are at a higher risk of arterial thrombosis and all types of thrombosis.
ARTHRITIS CARE & RESEARCH
(2023)
Review
Rheumatology
Amala Ambati, Jason S. Knight, Yu Zuo
Summary: This review discusses the recent international societal treatment guidelines for Antiphospholipid syndrome (APS) and proposes practical management algorithms for different APS sub-types. APS represents a disease spectrum with various clinical phenotypes, making clinical management challenging. While vitamin K antagonists or heparin/LMWH remain preferred for secondary APS thrombosis prophylaxis, some guidelines support the use of direct oral anticoagulants (DOACs) in certain situations. Individualized obstetric care with aspirin and heparin/LMWH improves pregnancy outcomes in pregnant individuals with APS. New therapeutic strategies are being developed for personalized and targeted APS management in the future.
CURRENT OPINION IN RHEUMATOLOGY
(2023)
Article
Rheumatology
Marwa Elkhalifa, Ana-Maria Orbai, Laurence S. Magder, Michelle Petri, Graciela S. Alarcon, Caroline Gordon, Joan Merrill, Paul R. Fortin, Ian N. Bruce, David Isenberg, Daniel Wallace, Ola Nived, Rosalind Ramsey-Goldman, Sang-Cheol Bae, John G. Hanly, Jorge Sanchez-Guerrero, Ann E. Clarke, Cynthia Aranow, Susan Manzi, Murray Urowitz, Dafna D. Gladman, Ken Kalunian, Victoria P. Werth, Asad Zoma, Sasha Bernatsky, Munther Khamashta, Soren Jacobsen, Jill P. Buyon, Mary Anne Dooley, Ronald van Vollenhoven, Ellen Ginzler, Thomas Stoll, Christine Peschken, Joseph L. Jorizzo, Jeffery P. Callen, Sam Lim, Murat Inanc, Diane L. Kamen, Anisur Rahman, Kristjan Steinsson, Andrew G. Franks
Summary: The study assessed the prevalence of anti-beta 2 glycoprotein I IgA in SLE compared to other rheumatic diseases and its association with disease manifestations. Results showed that anti-beta 2 glycoprotein I IgA is more common in patients with SLE, particularly in those of African descent.
Article
Hematology
Arne Vandevelde, Walid Chayoua, Bas de Laat, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: The study evaluated the traditional 40/80-unit thresholds used for categorization of antiphospholipid antibodies in different analytical systems, and found that alternative thresholds can improve consistency in interpretation. By using different thresholds, the positivity levels of antiphospholipid antibodies can be more accurately assessed.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Michelle Petri, Ian N. Bruce, Thomas Doerner, Yoshiya Tanaka, Eric F. Morand, Kenneth C. Kalunian, Mario H. Cardiel, Maria E. Silk, Christina L. Dickson, Gabriella Meszaros, Lu Zhang, Bochao Jia, Youna Zhao, Conor J. McVeigh, Marta Mosca
Summary: Baricitinib, an oral inhibitor of Janus kinase 1 and 2, was evaluated as a treatment for patients with systemic lupus erythematosus (SLE) in a 52-week phase 3 study. The study found that baricitinib did not significantly improve SLE disease activity compared with placebo, and there were no new safety concerns.
Article
Dermatology
S. Polesie, M. Gillstedt, H. Kittler, C. Rinner, P. Tschandl, J. Paoli
Summary: This study assessed the accuracy of international readers and machine learning methods in differentiating MIS from invasive melanomas and estimating the thickness of melanomas based on dermoscopy images. The results showed that readers and CNNs were able to predict melanoma thickness with relative accuracy using dermoscopy images.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Bartosz Kaczmarski, Derek E. Moulton, Ellen Kuhl, Alain Goriely
Summary: In filamentary structures, the activation of fibers through contraction or elongation generates internal stresses relieved by the filament's torsion and curvature. This process is fundamental in morphogenesis and other biological movements. A general theory has been developed to link the microscale activation of fibers to the macroscale generation of curvature and torsion.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2022)
Article
Rheumatology
Zeynep B. Erton, Rebecca K. Leaf, Danieli de Andrade, Ann E. Clarke, Maria G. Tektonidou, Vittorio Pengo, Savino Sciascia, Amaia Ugarte, H. Michael Belmont, Maria Gerosa, Paul R. Fortin, Chary Lopez-Pedrera, Tatsuya Atsumi, Zhouli Zhang, Hannah Cohen, Guilherme Ramires de Jesus, David W. Branch, Denis Wahl, Laura Andreoli, Esther Rodriguez-Almaraz, Michelle Petri, Giuseppe Barilaro, Yu Zuo, Bahar Artim-Esen, Rohan Willis, Rosana Quintana, Margarete B. G. Vendramini, Megan W. Barber, Maria L. Bertolaccini, Robert Roubey, Doruk Erkan
Summary: The study aimed to investigate the outcomes of patients with persistently positive antiphospholipid antibodies and the use of immunosuppression. The results showed that 14% of patients received immunosuppression, with half of them receiving it for selected microvascular and/or non-thrombotic aPL-related manifestations.
Review
Gastroenterology & Hepatology
Lucas Guillo, Maria Abreu, Remo Panaccione, William J. Sandborn, Valderilio F. Azevedo, Lianne Gensler, Bahar Moghaddam, Vineet Ahuja, Sabrina A. Ali, Matthieu Allez, Ashwin N. Ananthakrishnan, Abhik Bhattacharya, Marla Dubinsky, Anne Griffiths, Ailsa Hart, Burton Korelitz, Paulo G. Kotze, Iommaso E. Koutroubakis, Peter L. Lakatos, James O. Lindsay, Fernando Magro, Gerassimos J. Mantzaris, Slew C. Ng, Cohn O'Morain, Julian Panes, Tom Maso Parigi, Zhihua Ran, Gerhard Rogler, David T. Rubin, David B. Sachar, Britta Siegmund, Flavio Steinwurz, Curt Tysk, Stephan Vavricka, Sofa G. Verstraete, Antoine P. Brezin, Anna K. Haemel, Axel Dignass, Bruce E. Sands, Silvio Danese, Laurent Peyrin-Biroulet
Summary: Extraintestinal manifestations are common in patients with inflammatory bowel disease and pose challenges for diagnosis and treatment. The EXTRA initiative aims to achieve international consensus on assessing these manifestations in clinical trials. A panel of experts identified methods for diagnosing extraintestinal manifestations and measuring treatment outcomes. They recommend specialist expertise for confirming the diagnosis in most cases, except for axial spondyloarthritis where typical symptoms and MRI can be sufficient. Easy-to-measure endpoints were identified for assessing treatment response without specialist involvement. Guidelines were proposed for comprehensive evaluation of extraintestinal manifestations in future trials.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Rheumatology
Sara S. McCoy, Miguel Woodham, Christie M. Bartels, Ian J. Saldanha, Vatinee Y. Bunya, Noah Maerz, Esen K. Akpek, Matthew A. Makara, Alan N. Baer
Summary: This study aimed to investigate the impact of pain, dryness, and fatigue, the cardinal symptoms of Sjogren's disease, on disease severity. Through clustering analysis of patient data, four distinct symptom-based clusters were identified, and it was found that symptom burden and medication use did not correlate with disease severity.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Savino Sciascia, Massimo Radin, Irene Cecchi, Roger A. Levy, Doruk Erkan
Summary: APS lacks a uniform definition due to clinical heterogeneity, risk stratification strategies such as aPL-Score and Global APS Score are useful in clinical practice, but more international multicenter studies are needed to improve evidence quality.
Review
Dentistry, Oral Surgery & Medicine
Maria Pigg, Donald R. Nixdorf, Alan S. Law, Tara Renton, Yair Sharav, Lene Baad-Hansen, Thomas List
Summary: Pain is a common symptom in endodontic conditions, and differential diagnostic procedures are necessary to exclude other pain origins. Dentists and endodontists should be familiar with the new International Classification of Orofacial Pain (ICOP) to accurately identify various orofacial painful conditions and provide proper treatment.
JOURNAL OF ENDODONTICS
(2021)
Article
Rheumatology
Michael S. Putman, K. Bates Gribbons, Cristina Ponte, Joanna Robson, Ravi Suppiah, Anthea Craven, Richard Watts, Raashid Luqmani, Peter A. Merkel, Amy M. Archer, Peter C. Grayson
Summary: Histopathologic findings in GCA are strongly associated with the clinical diagnosis of GCA but have a limited role in identifying patterns of disease.
ARTHRITIS CARE & RESEARCH
(2022)
Article
Rheumatology
Manuel F. Ugarte-Gil, Jyoti Dubey, Gerald McGwin, John D. Reveille, Luis M. Vila, Graciela S. Alarcon
Summary: This study demonstrates the association between the SLICC-FI and damage accrual in SLE patients. The SLICC-FI is an important index that combines various aspects of the disease for the evaluation of SLE patients.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Optics
Supriya Sundareswaran, Srinivasan Karuppannan
Summary: The stable Form-I and metastable Form-II polymorphs of vanillin were successfully separated through nucleation control with selected templates. Both polymorphs exhibit good thermal stability and high SHG efficiency, making them promising for nonlinear optical applications.
OPTICS AND LASER TECHNOLOGY
(2021)
Article
Rheumatology
Michelle Petri, Helain Landy, Megan E. B. Clowse, Kim Gemzoe, Munther Khamashta, Milena Kurtinecz, Roger A. Levy, Andrew Liu, Rebecca Marino, Paige Meizlik, Jeanne M. Pimenta, Kelsey Sumner, Hugh Tilson, Mary Beth Connolly, Keele Wurst, Julia Harris, Holly Quasny, Patricia Juliao, David A. Roth
Summary: This study describes the available data on birth defects and pregnancy loss in women with systemic lupus erythematosus (SLE) exposed to belimumab. The results show that there is a risk of birth defects in belimumab-exposed pregnancies, although no consistent pattern of birth defects was observed across different datasets. Additionally, a higher proportion of belimumab-exposed women experienced pregnancy loss. However, due to the limited number of exposed pregnancies, confounding factors, and incomplete data, no clear recommendations can be made regarding the risk of birth defects and pregnancy loss with belimumab use.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Hematology
Thomas Foret, Virginie Dufrost, Marie Heymonet, Jessie Risse, Gilbert C. Faure, Huguette Louis, Jeremy Lagrange, Patrick Lacolley, Katrien Devreese, Sebastien Gibot, Veronique Regnault, Stephane Zuily, Denis Wahl
Summary: This study demonstrated that the levels of circulating endothelial cells (CECs) were associated with thromboembolic events in patients with antiphospholipid antibody (aPL) and/or autoimmune diseases.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Veterinary Sciences
Despoina Georgaki, Femke Vandael, Helena Cardoso de Carvalho Ferreira, Maria Eleni Filippitzi, Patrick De Backer, Mathias Devreese, Jeroen Dewulf, Siska Croubels
Summary: This study conducted a qualitative risk assessment to estimate the risks associated with reduced homogeneity and stability, as well as increased residual concentrations of antimicrobial drugs in medicated feed and drinking water on pig farms. Factors such as human error during the preparation of medicated feed and dosing pump type for medicated drinking water were found to pose moderate to high risks. It is crucial to identify and understand these factors in order to ensure the effectiveness and safety of antimicrobial drug treatment.
BMC VETERINARY RESEARCH
(2023)
Article
Medicine, General & Internal
Konstantinos Thomas, Argyro Lazarini, Evripidis Kaltsonoudis, Paraskevi V. Voulgari, Alexandros A. Drosos, Argyro Repa, Ainour Molla Ismail Sali, Prodromos Sidiropoulos, Panagiota Tsatsani, Sousana Gazi, Kalliopi Fragkiadaki, Maria G. Tektonidou, Petros P. Sfikakis, Pelagia Katsimbri, Dimitrios Boumpas, Evangelia Argyriou, Kyriaki A. Boki, Konstantina Karagianni, Christina Katsiari, Gerasimos Evangelatos, Alexios Iliopoulos, Eleftheria P. Grika, Panagiotis G. Vlachoyiannopoulos, Theodoros Dimitroulas, Alexandros Garyfallos, Konstantinos Melissaropoulos, Panagiotis Georgiou, Constantinos Georganas, Periklis Vounotrypidis, Konstantinos Ntelis, Maria Areti, George D. Kitas, Dimitrios Vassilopoulos
Summary: The rate of pneumococcal vaccination among rheumatoid arthritis (RA) patients remains suboptimal, with 40% remaining unvaccinated. Severe disease, bDMARD use, comorbidities, and influenza vaccination were significant factors associated with pneumococcal vaccination, highlighting the need for cultivating a vaccination culture in RA patients.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Laura Andreoli, Cecilia B. Chighizola, Luca Iaccarino, Angela Botta, Maria Gerosa, Veronique Ramoni, Chiara Tani, Bonnie Bermas, Antonio Brucato, Jill Buyon, Irene Cetin, Christina D. Chambers, Megan E. B. Clowse, Nathalie Costedoat-Chalumeau, Maurizio Cutolo, Sara De Carolis, Radboud Dolhain, Elisa M. Fazzi, Frauke Foerger, Ian Giles, Isabell Haase, Munther Khamashta, Roger A. Levy, Pier Luigi Meroni, Marta Mosca, Catherine Nelson-Piercy, Luigi Raio, Jane Salmon, Peter Villiger, Marie Wahren-Herlenius, Marianne Wallenius, Cristina Zanardini, Yehuda Shoenfeld, Angela Tincani
Summary: Autoimmune rheumatic diseases (ARD) pose challenges to reproductive health. Preconception counseling should consider factors such as fertility, disease impact on pregnancy outcomes, disease activity during pregnancy, medication compatibility, and biomarkers predictive of adverse pregnancy outcomes (APO). Diseases like preeclampsia and pregnancy-induced hypertension are more likely to occur in women with ARD. Placental insufficiency can result in restricted fetal growth. Treatment with compatible drugs is essential for maternal and fetal wellbeing. While limited data is available on medication usage during pregnancy, TNF inhibitors are recommended. Non-medical issues like sexual dysfunction and long-term outcomes of children also require attention in this review. Collaborative research and pregnancy registries will contribute to future insights.
AUTOIMMUNITY REVIEWS
(2023)
Article
Rheumatology
Binod Neupane, Pragya Shukla, Mahmoud Slim, Amber Martin, Michelle Petri, George K. Bertsias, Alfred H. J. Kim, Antonis Fanouriakis, Roger A. Levy, Deven Chauhan, Nick Ballew
Summary: This study aimed to compare the efficacy of belimumab and anifrolumab in SLE patients for informed treatment practices. The results showed that belimumab and anifrolumab had similar efficacy in SLE patients, but the uncertainty around the point estimate means we cannot rule out the possibility of clinically meaningful benefit for either treatment. Further research is needed to identify which patient groups may benefit more from anifrolumab or belimumab.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Alexandros Panagiotopoulos, Christos Koutsianas, Nikolaos Kougkas, Dimitra Moschou, Vasiliki-Kalliopi Bournia, Sousana Gazi, Maria G. Tektonidou, Dimitrios Vassilopoulos, Petros P. Sfikakis, George E. Fragoulis
Summary: This study reports the efficacy of switching to ixekizumab (IXE) after inadequate response to another interleukin-17 (IL-17) inhibitor (SEC) in psoriatic arthritis (PsA) patients. The results showed improvements in peripheral arthritis and skin involvement, as well as significant improvements in axial disease in patients with PsA. These findings suggest that IXE is effective in treating PsA patients, including those with axial disease, in a real-world setting.
RHEUMATOLOGY INTERNATIONAL
(2023)
Meeting Abstract
Hematology
Arne Vandevelde, Luna Crevits, Katrien M. J. Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Pauline Vermeiren, Arne Vandevelde, Katrien M. J. Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Meeting Abstract
Hematology
Delphine De Smet, Dimitri Hemelsoet, Katrien Devreese
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2023)
Article
Rheumatology
Ian N. Bruce, Joy Buie, Lauren Bloch, Sang-Cheol Bae, Karen Costenbader, Roger A. Levy, Victoria P. Werth, Ashley Marion, Sanjyot Sangodkar, Susan Manzi
Summary: Lupus, a complex disease, poses challenges in diagnosis due to non-specific symptoms and a lack of diagnostic criteria and referral pathways. To address these issues, virtual meetings were held with experts in lupus care, including physicians, treatment developers, and patient advocacy group representatives. The discussions highlighted the need for a clearer understanding of lupus, advancements in biotechnology, and potential development of a lupus spectrum to support timely and accurate diagnosis.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Rheumatology
Tatsuya Atsumi, Cecilia B. Chighizola, Yuichiro Fujieda, Ian Mackie, Massimo Radin, Robert Roubey, Maria Laura Bertolaccini
Summary: Classification criteria for antiphospholipid syndrome (APS) require specific antibodies to satisfy the laboratory disease definition, but there have been additional antibodies proposed in recent years. This article evaluates these new antibodies through the study and discussion of relevant data, and also discusses the testing of LA and the value of triple positivity.
Article
Rheumatology
Lorena Rodriguez-Martinez, Cristina Garcia-Moreno, Eva Perez-Pampin, Maria J. Gomara, Juan C. Sarmiento-Monroy, Yolanda Lopez-Golan, Jose A. Gomez-Puerta, Antonio Mera-Varela, Carmen Conde, Raimon Sanmarti, Isabel Haro, Antonio Gonzalez
Summary: Autoantibodies play a critical role in the pathogenesis and clinical assessment of rheumatoid arthritis. The anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies have been claimed to have high sensitivity for all rheumatoid arthritis patients. However, the sensitivity of anti-MAA antibodies varies significantly between patient collections and is determined by complex factors including ethnicity, smoking, and sex.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Hematology
Arne Vandevelde, Jean-Christophe Gris, Gary W. Moore, Jacek Musial, Stephane Zuily, Denis Wahl, Katrien M. J. Devreese
Summary: Currently, the added value of antiphosphatidylserine/prothrombin antibodies testing in the diagnosis of obstetric antiphospholipid syndrome seems limited compared with other antibodies. However, it may be useful in specific subsets of patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Letter
Health Care Sciences & Services
Nick Ballew, Aneela Mian, Roger Abramino Levy, Matt Bradley
JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH
(2023)