Article
Microbiology
Ying-mei Zhang, Xiao-xia Guo, Shu-fang Jiang, Chun-xiao Li, Dan Xing, Heng-duan Zhang, Yan-de Dong, Tong-yan Zhao
Summary: This study confirms the vector competence of different strains of Aedes Albopictus mosquitoes in China for West Nile virus (WNV) infection and transmission. The study also reveals that WNV can be transmitted to progeny through diapause eggs of Aedes Albopictus, maintaining its natural circulation during inter-epidemic seasons.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Cell Biology
Sundy N. Y. Yang, Belinda Maher, Chunxiao Wang, Kylie M. Wagstaff, Johanna E. Fraser, David A. Jans
Summary: This study identifies two drugs that can inhibit the replication of dengue virus and other flaviviruses by directly binding to a viral protein.
Letter
Immunology
Edward Davila, Nadia A. Fernandez-Santos, Jose Guillermo Estrada-Franco, Lihua Wei, Jesus A. Aguilar-Duran, Maria de J. Lopez-Lopez, Roberto Solis-Hernandez, Rosario Garcia-Miranda, Doireyner Daniel Velazquez-Ramirez, Jasiel Torres-Romero, Susana Arellano Chavez, Raul Cruz-Cadena, Roberto Navarro-Lopez, Adalberto A. Perez de Leon, Carlos Guichard-Romero, Estelle Martin, Wendy Tang, Matthias Frank, Monica Borucki, Michael J. Turell, Alex Pauvolid-Correa, Mario A. Rodriguez-Perez, Hector Ochoa-Diaz-Lopez, Sarah A. Hamer, Gabriel L. Hamer
Summary: The study tested 294 domestic pet dogs in Mexico for neutralizing antibodies for mosquito-borne flaviviruses, finding high exposure to West Nile virus in some areas and low exposure to Aedes-borne flaviviruses. Domestic dogs may serve as useful sentinels for monitoring West Nile virus.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Environmental Sciences
Maria S. Lopez, Andre A. Gomez, Gabriela V. Müller, Elisabet Walker, Michael A. Robert, Elizabet L. Estallo
Summary: This study analyzed the relationship between climate change and dengue fever, and found that there is a correlation between increasing temperatures and the rise in dengue cases as well as its geographical expansion. This suggests that climate change is an important driver of the continuous spread of dengue fever in Argentina.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Virology
Caroline J. Stephenson, Heather Coatsworth, Christy M. Waits, Nicole M. Nazario-Maldonado, Derrick K. Mathias, Rhoel R. Dinglasan, John A. Lednicky
Summary: Dengue viruses (DENVs) cause the greatest public health burden globally among arthropod-borne viruses, with transmission risk expanding from tropical to subtropical regions due to the increasing range of its principal mosquito vector, Aedes aegypti. In Florida, focal outbreaks of dengue fever (dengue) have increased since 2009, and the study found that low passage DENVs were more infectious to and had higher transmission potential by Ae. aegypti mosquitoes. Vector competence across all DENV serotypes was greater for mosquitoes from areas with the highest dengue incidence in south FL compared to north FL, indicating a targeted mosquito-plus-pathogen screening approach could help estimate DENV transmission risk more accurately.
Review
Pharmacology & Pharmacy
Ivo C. C. Martins, Rafaela C. C. Ricardo, Nuno C. C. Santos
Summary: Dengue, West Nile, and Zika viruses are vector-borne flaviviruses that cause disease outbreaks with potentially severe symptoms and socioeconomic repercussions. Currently, there are no specific treatments available, and only generic symptom relief is possible. The effectiveness of the first dengue vaccine, Dengvaxia, is limited. Prophylactic approaches against other viruses are even more restricted. Therefore, there is a need for therapeutic strategies.
Review
Parasitology
Mario A. J. Golding, Simmoy A. A. Noble, Nadia K. Khouri, Rhaheem N. A. Layne-Yarde, Inshan Ali, Simone L. Sandiford
Summary: Dengue remains a significant public health concern in Latin America and the Caribbean, with both horizontal and vertical transmission contributing to its spread. While there have been reports of vertical transmission of the dengue virus, its epidemiological significance is still debated.
PARASITES & VECTORS
(2023)
Article
Biochemical Research Methods
Yuliang Chen, Tao Liu, Xiaolin Yu, Qinghui Zeng, Zixi Cai, Haisheng Wu, Qingying Zhang, Jianpeng Xiao, Wenjun Ma, Sen Pei, Pi Guo
Summary: This study proposes an ensemble forecast system for dengue fever, which addresses the challenge of predicting outbreaks with different scales. By combining a susceptible-infected-recovered (SIR) model with the ensemble adjusted Kalman filter (EAKF) algorithm, the system generates real-time forecasts of dengue fever spread dynamics and adjusts the predicted outbreak size based on updated information. The system outperforms a generalized additive model approach in accurately projecting peak timing, peak intensity, and total incidence in retrospective forecasts of dengue outbreaks in Guangzhou, China.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Talya Shragai, Juliana Perez-Perez, Marcela del Pilar Quimbayo-Forero, Raul Rojo, Laura C. Harrington, Guillermo Rua-Uribe
Summary: Dengue is becoming an increasing global threat in rapidly growing urban areas. This study analyzes nine years of dengue case data in Medellin, Colombia and finds that changes in accessibility and usage of public transit are correlated with changes in the spread and magnitude of localized outbreaks. Locations closer to and with greater utilization of public transit have higher dengue incidence, with a stronger effect observed in lower socioeconomic status areas. These results emphasize the importance of public health services in conjunction with urban growth.
SCIENTIFIC REPORTS
(2022)
Article
Parasitology
Kien Duong Thi Hue, Daniela da Silva Goncalves, Vi Tran Thuy, Long Thi Vo, Dui Le Thi, Nhu Vu Tuyet, Giang Nguyen Thi, Trang Huynh Thi Xuan, Nguyet Nguyen Minh, Phong Nguyen Thanh, Sophie Yacoub, Cameron P. Simmons
Summary: This study aims to investigate the impact of Wolbachia endosymbiont wMel strain on the vertical transmission of DENV. The results demonstrate that wMel infection can effectively reduce the vertical transmission rate of DENV.
PARASITES & VECTORS
(2023)
Article
Infectious Diseases
Christin Koersten, Amira A. Al-Hosary, Cora M. Holicki, Mandy Schaefer, Birke A. Tews, Ana Vasic, Ute Ziegler, Martin H. Groschup, Cornelia Silaghi
Summary: The two mosquito-borne zoonotic flaviviruses, West Nile virus (WNV) and Usutu virus (USUV), which have been endemic in many European countries, can coexist in vertebrate hosts. This study found that the susceptibility of different mosquito species to WNV and USUV varies, and coinfections mainly occur in Culex mosquitoes.
TRANSBOUNDARY AND EMERGING DISEASES
(2023)
Article
Virology
Christin Koersten, Amira A. Al-Hosary, Mandy Schaefer, Birke A. Tews, Doreen Werner, Helge Kampen, Ana Vasic, Cornelia Silaghi
Summary: This study suggests that the German mosquito Ae. punctor does not play an important role in the transmission of West Nile virus (WNV) in Germany.
Review
Immunology
Zhuanzhuan Liu, Qingxin Zhang, Liya Li, Junjie He, Jinyang Guo, Zichen Wang, Yige Huang, Zimeng Xi, Fei Yuan, Yiji Li, Tingting Li
Summary: This review explores the correlations between temperature and dengue epidemics, including the distribution and development of Aedes mosquitoes, the structure of DENV, and the vector competence of Aedes mosquitoes. Additionally, it discusses the immune and metabolic mechanism through which temperature affects the vector competence of Aedes mosquitoes to transmit DENV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Virology
Rachel Milomba Velu, Geoffrey Kwenda, Samuel Bosomprah, Moses Ngongo Chisola, Michelo Simunyandi, Caroline Cleopatra Chisenga, Flavien Nsoni Bumbangi, Nicholus Chintu Sande, Limonty Simubali, Monicah Mirai Mburu, John Tembo, Matthew Bates, Martin Chitolongo Simuunza, Roma Chilengi, Yasuko Orba, Hirofumi Sawa, Edgar Simulundu
Summary: This study aims to predict and evaluate the potential risk areas for West Nile Virus (WNV) and Chikungunya Virus (CHIKV) transmission in Zambia based on climate and mosquito species data. The findings identified Lake Kariba, the Kafue River, and the Luangwa Rivers, as well as the Mumbwa, Chibombo, Kapiri Mposhi, and Mpika districts as suitable habitats for the mosquito species that can transmit the viruses. Rainfall and temperature extremes were identified as the most influential variables in the predictive models.
Article
Chemistry, Multidisciplinary
Jose-Manuel Cruz, Jorge Gonzalez-Gutierrez, R. Salgado-Garcia, O. Diaz-Hernandez
Summary: Dengue is transmitted by Aedes aegypti and Aedes albopictus mosquitoes, causing flu-like symptoms and potentially life-threatening complications. A new stochastic model has been developed to understand the transmission dynamics, considering all known mechanisms and environmental factors. The model shows that a combination of transmission routes and favorable conditions could explain the persistence of the virus in the population.
APPLIED SCIENCES-BASEL
(2023)