Article
Public, Environmental & Occupational Health
Hao Wen, Xiaojing Wei, Shuqi Ge, Jingchun Zeng, Wen Luo, Rouhao Chen, Yu Dong, Songhua Xiao, Yunfeng Lai, Liming Lu
Summary: Acupuncture as an adjunctive therapy for patients receiving methadone maintenance treatment shows significant clinical and economic benefits, including reducing methadone dosage, improving drug cravings, and alleviating insomnia, leading to an improved quality of life. However, the cost of acupuncture may exceed what society is willing to pay, indicating a need for further study.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Psychiatry
Hao Wen, Rouhao Chen, Peiming Zhang, Xiaojing Wei, Yu Dong, Shuqi Ge, Wen Luo, Yiping Zhou, Songhua Xiao, Liming Lu
Summary: The study conducted a meta-analysis to compare acupuncture-related therapies with methadone maintenance treatment (MMT) for opioid dependence patients. The results indicated that manual acupuncture may be the best choice, and emphasized the need for further research and efforts to reduce relapse and promote recovery.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Hengfen Gong, Ying Huang, Xingjia Zhu, Wei Lu, Zhengyi Cai, Na Zhu, Juan Huang, Ying Jin, Xirong Sun
Summary: This study aimed to explore the impact of intermittent theta burst stimulation (iTBS)-MMT combination on craving and emotional symptoms of opioid use disorder. Results showed that patients receiving iTBS-MMT combination treatment had significant improvement in anxiety, depression, and craving reduction compared to MMT alone. Therefore, iTBS-MMT combination treatment may be more effective in reducing drug cravings and improving emotional well-being.
PSYCHIATRY RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Michael Soyka
Summary: Methadone and buprenorphine are commonly used medications in opioid maintenance treatment, with no established algorithm for transitioning between them. Transfer is recommended for patients on low doses of methadone, but there are reports suggesting transition from higher doses may be possible. Various dosing strategies have been proposed to alleviate withdrawal symptoms and facilitate transfer.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Nikki Bozinoff, Siyu Men, Paul Kurdyak, Peter Selby, Tara Gomes
Summary: This population-based cohort study found that tapering buprenorphine after at least 1 year of therapy, a slower rate of taper, and a lower percentage of days with dose decrease were significantly associated with a lower risk of opioid overdose. These findings underscore the importance of a carefully planned taper in reducing opioid-related overdose deaths.
Article
Chemistry, Medicinal
Hongsong Feng, Rui Wang, Chang-Guo Zhan, Guo-Wei Wei
Summary: In this study, a deep generative model combining a stochastic differential equation (SDE)-based diffusion model with a pretrained autoencoder is proposed. The model efficiently generates molecules targeting multiple opioid receptors and evaluates their ADMET properties. Molecular optimization is performed to enhance the pharmacokinetic properties of lead compounds. Advanced binding affinity predictors are built using molecular fingerprints, providing a valuable tool for evaluating the pharmacological effects of the generated molecules.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Psychiatry
Meichen Li, Yuting Wang, Keyi Li, Xiaoyan Xu, Lixing Zhuang
Summary: This study aims to verify the effectiveness of Jin's three-needle therapy (JTNT) for patients with post-stroke anxiety (PSA) and observe the changes in serum indicators and brain region activity using ELISA and rs-fMRI. The method is a 16-week randomized controlled trial with three groups of participants, evaluating anxiety symptoms and quality of life using multiple scales. The objective is to provide high-quality clinical evidence and explore the mechanism of action.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Stephanie Paula Elisabeth Guillery, Rainer Hellweg, Soeren Enge, Ulrich Bohr, Hagen Kunte, Golo Kronenberg
Summary: A survey study was conducted from February to June 2018 on outpatients receiving diamorphine or methadone/levomethadone maintenance treatment, highlighting the higher satisfaction levels of diamorphine patients with their substitute drug and reductions in relapse-related behaviors and cravings.
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION
(2021)
Article
Medicine, General & Internal
Andi Camden, Teresa To, Joel G. Ray, Tara Gomes, Li Bai, Astrid Guttmann
Summary: Early identification of people who use opioids in pregnancy is crucial for improving health outcomes for pregnant individuals and infants. This study categorized individuals who used opioids during pregnancy into distinct clinical groups and found that these groups were associated with varying levels of risk for postpartum drug overdose or death.
Article
Public, Environmental & Occupational Health
Anna E. Austin, Vito Di Bona, Mary E. Cox, Scott K. Proescholdbell, Rebecca B. Naumann
Summary: This study aims to compare the mortality rate and causes of mortality among infants with neonatal opioid withdrawal syndrome, taking into account whether their mothers received medication for opioid use disorder during pregnancy. The results show that infants of mothers who did not receive medication for opioid use disorder had a higher mortality rate, primarily due to sudden unexpected infant death syndrome. This highlights the importance of assessing potential differences in outcomes according to whether infants with neonatal opioid withdrawal syndrome were exposed to medication for opioid use disorder, and calls for equitable access to medication and support services during pregnancy.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Review
Substance Abuse
Hao Wen, Xingyu Xiang, Yong Jiang, Haoyu Zhang, Peiming Zhang, Rouhao Chen, Xiaojing Wei, Yu Dong, Songhua Xiao, Liming Lu
Summary: This study aimed to evaluate the efficacy of multiple psychosocial interventions for opioid-dependent individuals receiving methadone maintenance treatment. The findings indicated that cognitive-behavioral therapy and educational and behavioral counseling were more effective than treatment as usual. The study concluded that educational and behavioral counseling may be the most effective intervention, while behavioral couples' therapy may be the best option for treatment discontinuation.
Article
Pharmacology & Pharmacy
Erika N. Titus-Lay, Heather A. Jaynes, Elena Tomaselli Muensterman, Todd A. Walroth, Carol A. Ott, Zeruesenay Desta, Gabriela Williams, Paul R. Moe, Michelle Wilbrandt, James E. Tisdale
Summary: This study aimed to investigate the incidence of QT interval prolongation among patients receiving maintenance methadone therapy in an urban opioid treatment program, and to explore the relationship with serum methadone concentrations. The results showed that approximately 15% of patients experienced QT interval prolongation, and there was a correlation between serum methadone concentrations and QTc intervals.
Article
Psychiatry
Didier Jutras-Aswad, Bernard Le Foll, Keith Ahamad, Ron Lim, Julie Bruneau, Benedikt Fischer, Jurgen Rehm, T. Cameron Wild, Evan Wood, Suzanne Brissette, Lea Gagnon, Jill Fikowski, Omar Ledjiar, Benoit Masse, M. Eugenia Socias
Summary: The study aimed to compare the effectiveness of flexible take-home buprenorphine/naloxone and supervised methadone in reducing opioid use among prescription-type opioid consumers with opioid use disorder. The results showed that the flexible model of care with buprenorphine/naloxone was safe and noninferior to methadone therapy in reducing opioid use.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Clinical Neurology
S. Jeremy Lum, M. Katrina Bird, Jennifer Wilkie, J. Samuel Millard, Sachie Pallimulla, A. Kelly Newell, M. Ian Wright
Summary: The research describes a clinically relevant rat model of MMT to assess the long-term behavioral and neurobiological effects of prenatal methadone exposure on adolescent offspring. The results showed that methadone-exposed offspring had significantly lower body and brain weights at birth, and exhibited cognitive impairments and working memory learning deficits during adolescence.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Clinical Neurology
Yu Dong, Baochao Fan, Enliang Yan, Rouhao Chen, Xiaojing Wei, Jie Zhan, Jingchun Zeng, Hao Wen, Liming Lu
Summary: This study investigated the impact of acupuncture intervention on methadone maintenance treatment (MMT) patients, constructing a decision-tree model. The results showed that acupuncture, years of opioid use, route of previous opioid use, MMT time, and age were key predictors for MMT treatment. The findings suggest that considering these factors may improve the efficacy of acupuncture-assisted MMT strategies.
FRONTIERS IN NEUROLOGY
(2022)