Article
Gastroenterology & Hepatology
Yasmina Chouik, Claire Francoz, Eleonora De Martin, Olivier Guillaud, Armand Abergel, Mario Altieri, Louise Barbier, Camille Besch, Olivier Chazouilleres, Filomena Conti, Christophe Corpechot, Sebastien Dharancy, Francois Durand, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie-Noelle Hilleret, Pauline Houssel-Debry, Nassim Kamar, Anne Minello, Martine Neau-Cransac, Georges-Philippe Pageaux, Sylvie Radenne, Olivier Roux, Faouzi Saliba, Didier Samuel, Claire Vanlemmens, Marie-Lorraine Woehl-Jaegle, Vincent Leroy, Jean-Charles Duclos-Vallee, Jerome Dumortier
Summary: This study describes the early outcomes of liver transplantation for autoimmune hepatitis (AIH). The prognosis is good for AIH patients after transplantation, and pre-transplant immunosuppression does not affect the outcomes. However, the presence of acute kidney injury at the time of transplantation can negatively impact the prognosis.
LIVER INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Bradley J. Gardiner, Sue J. Lee, Allisa N. Robertson, Yvonne Cristiano, Gregory I. Snell, C. Orla Morrissey, Anton Y. Peleg, Glen P. Westall
Summary: This study reviewed the application of Quantiferon-Cytomegalovirus (QF-CMV) testing in lung transplant recipients and found a strong correlation between QF-CMV results and serostatus. D+/R- patients were unlikely to test positive while receiving prophylaxis. Extended prophylaxis was associated with delayed, reduced, and milder CMV infection. However, the incremental predictive value of QF-CMV was limited after accounting for serostatus.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Review
Immunology
Monika Svorcova, Rene Novysedlak, Robert Lischke, Jiri Vachtenheim, Zuzana Strizova
Summary: Lung transplant recipients are at higher risk from COVID-19 and their immune response to vaccines is uncertain. Observational studies show some solid organ transplant patients can generate sufficient antibody levels, but other studies indicate most patients have no immune response after vaccination. The third booster dose of COVID-19 vaccines may be an effective measure in preventing severe COVID-19 infection in lung transplant recipients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Oana Joean, Tobias Welte, Jens Gottlieb
Summary: Despite progress in follow-up strategies, lung transplant recipients still face high morbidity and mortality due to infection risks and chronic lung allograft dysfunction. Quick diagnosis, early treatment, and follow-up are crucial but challenging due to a wide range of pathogens and compromised immune responses in transplant recipients.
Review
Respiratory System
Sakhee Kotecha, Steven Ivulich, Gregory Snell
Summary: Lung transplantation has seen significant advancements in immunosuppression management over the past three decades, moving towards a more personalized approach. As the demographics of lung transplant recipients change and survival rates improve, the management of immunosuppression related comorbidities becomes increasingly important.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Medicine, General & Internal
Fernando Luis Scolari, Laura Caroline Tavares Hastenteufel, Lidia Einsfeld, Julia Bueno, Leticia Orlandin, Nadine Clausell, Livia Adams Goldraich
Summary: Heart transplant recipients in Southern Brazil showed a high rate of COVID-19 infection with typical symptom presentation in most cases. A significant proportion required hospitalization and supplementary oxygen support, and experienced complications. In-hospital lethality among infected heart transplanted recipients was similar to previously reported data worldwide despite the high rates of infection in Latin America.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Lauryn A. Benninger, Cesar Trillo, Jorge Lascano
Summary: CFTR modulator therapy may improve extrapulmonary manifestations of cystic fibrosis in post-lung transplant recipients without affecting graft function or immunosuppressive drug levels.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Immunology
Maria Iglesias-Escudero, David San Segundo, David Merino-Fernandez, Victor M. Mora-Cuesta, Patricia Lamadrid, Marta Alonso-Pena, Sandra Raso, David Iturbe, Sonia Fernandez-Rozas, Jose Cifrian, Marcos Lopez-Hoyos
Summary: Lung transplantation is a primary treatment for end-stage lung diseases, but long-term survival is limited. The study explores the dysregulation of immune mechanisms and the role of myeloid-derived suppressor cells (MDSCs) in promoting graft tolerance. The results suggest that increased frequencies of Mo-MDSCs after acute cellular rejection may be associated with the development of chronic lung allograft dysfunction (CLAD).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Emergency Medicine
Brit Long, William J. Brady, Alin Gragossian, Alex Koyfman, Michael Gottlieb
Summary: Cardiac transplant is an effective therapy for end-stage heart failure, but patients may experience complications such as graft failure, rejection, infection, and dysrhythmias. Additionally, patients with acute coronary syndrome can have atypical presentations, requiring comprehensive evaluation and management by healthcare professionals.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Andre Karch, Daniela Schindler, Andrea Kuehn-Steven, Rainer Blaser, Klaus A. Kuhn, Lisa Sandmann, Claudia Sommerer, Markus Guba, Uwe Heemann, Jens Stroehaker, Stephan Gloeckner, Rafael Mikolajczyk, Dirk H. Busch, Thomas F. Schulz
Summary: The DZIF Transplant Cohort is a multicentre prospective cohort study focusing on infectious complications after solid organ and stem cell transplantation. It aims to understand the risk factors associated with infections, collect detailed data and biosamples to facilitate studies in infectious diseases and transplant medicine. The study has collected baseline data and biosamples from approximately 1400 patients as of January 2020, with plans to recruit 3500 patients by 2023 and continue follow-up visits and documentation of infectious events until at least 2025.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Orthopedics
Ruben Dukan, Herve Mal, Yves Castier, Marc-Antoine Rousseau, Patrick Boyer
Summary: This study aimed to determine outcomes and complications after shoulder arthroplasty in lung transplant recipients. Results showed that shoulder arthroplasty is a safe procedure in this vulnerable population, with significant improvements in shoulder function and quality of life post-operatively.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2021)
Article
Infectious Diseases
Nikolaus Kneidinger, Matthias Hecker, Vasiliki Bessa, Ina Hettich, Alexandra Wald, Sabine Wege, Anna-Barbara Nolde, Maike Oldigs, Zulfiya Syunyaeva, Heinrike Wilkens, Jens Gottlieb
Summary: This study aims to assess the outcome and associated factors in lung transplant recipients during the Omicron era of COVID-19, and found that age and glomerular filtration rate < 30 ml/min/1.73m(2) were independent risk factors for severe or critical COVID-19.
Article
Microbiology
Antonio F. Caballero-Bermejo, Ignacio Darnaude-Ximenez, Myriam Aguilar-Perez, Alicia Gomez-Lopez, Aranzazu Sancho-Lopez, Cristina Lopez Garcia-Gallo, Gema Diaz Nuevo, Elena Diago-Sempere, Belen Ruiz-Antoran, Cristina Avendano-Sola, Piedad Ussetti-Gil
Summary: This study investigated the pharmacokinetics of Isavuconazole (ISA) in lung transplant recipients and found that ISA achieves adequate concentrations in the lung with a tolerable safety profile.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Dermatology
Marco Vecchiato, Stefano Piaserico, Giulia Biolo, Anna Chiara Frigo, Monica Loy, Federico Rea, Irene Russo, Mauro Alaibac
Summary: This study aimed to determine the incidence and risk factors of skin cancers in lung transplant recipients, finding that age, gender, phototype, and voriconazole use were significant predictors for squamous cell carcinoma development. Male gender and phototype were identified as independent risk factors for basal cell carcinoma.
DERMATOLOGIC THERAPY
(2021)
Review
Immunology
Cynthia L. Miller, M. O. M. Jane, James S. Allan, Joren C. Madsen
Summary: Allograft failure in lung transplantation is a major barrier, and standard immunosuppressive regimens have not been successful. Recent research on the mechanisms of lung allograft rejection has led to the development of new strategies to promote long-term graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Correction
Immunology
Nadia Caccamo, Gabriella Pietra, Lucy C. Sullivan, Andrew G. Brooks, Teresa Prezzemolo, Marco P. La Manna, Diana Di Liberto, Simone A. Joosten, Krista E. van Meijgaarden, Paola Di Carlo, Lucina Titone, Lorenzo Moretta, Maria C. Mingari, Tom H. M. Ottenhoff, Francesco Dieli
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Robert B. Gilmore, Kirstin M. Taylor, C. Orla Morrissey, Bradley J. Gardiner
Summary: This article reviews the available literature and outlines a practical approach to the diagnosis and management of cytomegalovirus (CMV) in patients with inflammatory bowel disease (IBD).
INTERNAL MEDICINE JOURNAL
(2022)
Article
Infectious Diseases
Iain J. Abbott, Elke van Gorp, Kelly L. Wyres, Steven C. Wallis, Jason A. Roberts, Joseph Meletiadis, Anton Y. Peleg
Summary: The effectiveness of oral fosfomycin in treating urinary tract infections caused by non-Escherichia coli uropathogens, including Klebsiella pneumoniae, is uncertain.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Bradley J. Gardiner, Sue J. Lee, Allisa N. Robertson, Yvonne Cristiano, Gregory I. Snell, C. Orla Morrissey, Anton Y. Peleg, Glen P. Westall
Summary: This study reviewed the application of Quantiferon-Cytomegalovirus (QF-CMV) testing in lung transplant recipients and found a strong correlation between QF-CMV results and serostatus. D+/R- patients were unlikely to test positive while receiving prophylaxis. Extended prophylaxis was associated with delayed, reduced, and milder CMV infection. However, the incremental predictive value of QF-CMV was limited after accounting for serostatus.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Genetics & Heredity
Mohammad Hamidian, Ram P. Maharjan, Daniel N. Farrugia, Natasha N. Delgado, Hue Dinh, Francesca L. Short, Xenia Kostoulias, Anton Y. Peleg, Ian T. Paulsen, Amy K. Cain
Summary: This study reports the complete genome sequences of six diverse environmental strains of A. baumannii and reveals their similar virulence potential to nosocomial strains but greater sensitivity to antibiotics.
MICROBIAL GENOMICS
(2022)
Review
Infectious Diseases
Kelly A. Cairns, Iain J. Abbott, Michael J. Dooley, Anton Y. Peleg, Trisha N. Peel, Andrew A. Udy
Summary: This study aimed to determine whether daptomycin therapeutic drug monitoring (TDM), including dose adjustment, improves the clinical outcomes of adult patients with Gram-positive infections. A systematic review found no studies exploring the efficacy of routine daptomycin TDM in comparison with fixed dosing regimens. Further well-designed, comparative studies are needed to determine the role of daptomycin TDM in patients with Gram-positive infections.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Infectious Diseases
Iain J. Abbott, Elke van Gorp, Hugh Cottingham, Nenad Macesic, Steven C. Wallis, Jason A. Roberts, Joseph Meletiadis, Anton Y. Peleg
Summary: The study found that high-dose oral ciprofloxacin therapy (750 mg 12 hourly) has good antibacterial activity against ceftriaxone-resistant Escherichia coli, especially with ciprofloxacin MIC <= 1 mg/L.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Microbiology
Kelly A. Cairns, Andrew A. Udy, Trisha N. Peel, Iain J. Abbott, Michael J. Dooley, Anton Y. Peleg
Summary: Vancomycin-resistant enterococci (VRE) are a common cause of bloodstream infections (BSIs) with high morbidity and mortality rates. The management of VRE BSI presents significant challenges, including drug dosing, resistance emergence, and optimal treatment strategies. Therapeutic drug monitoring (TDM) shows promise in predicting drug toxicity for VRE-active agents, but there is limited evidence for predicting antimicrobial efficacy for VRE BSIs. This article provides an overview of treatment options, the role of TDM in clinical infection management, and future challenges and perspectives.
CLINICAL MICROBIOLOGY REVIEWS
(2023)
Article
Surgery
Bradley J. Gardiner, Jessica P. Bailey, Mia A. Percival, Beth A. Morgan, Victoria M. Warner, Sue J. Lee, C. Orla Morrissey, David M. Kaye, Anton Y. Peleg, Andrew J. Taylor
Summary: This study evaluated the incidence and severity of cytomegalovirus (CMV) infection in seropositive heart transplant recipients and found that CMV infection was associated with longer hospitalization, increased intensive care readmission, and higher mortality rates. The use of valganciclovir prophylaxis was protective against CMV infection. These findings support the routine use of antiviral prophylaxis in all CMV seropositive heart transplant recipients.
CLINICAL TRANSPLANTATION
(2023)
Article
Microbiology
Micaela Mossop, Luca Robinson, Jhih-Hang Jiang, Anton Y. Peleg, Luke Blakeway, Nenad Macesic, Audrey Perry, Stephen Bourke, Fatima R. Ulhuq, Tracy Palmer
Summary: One third of CF patients in the UK are co-infected with both Staphylococcus aureus and Pseudomonas aeruginosa, which contribute to lung tissue destruction and respiratory failure. This study aims to characterize twenty-five clinical S. aureus isolates from CF patients, including those with mono- and coinfection with P. aeruginosa, using molecular and phenotypic tools.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Pathology
Xenia Kostoulias, Christina C. Chang, Jessica Wisniewski, Iain J. Abbott, Helen Zisis, Amanda Dennison, Denis W. Spelman, Anton Y. Peleg
Summary: We investigated the effectiveness of ceftolozane-tazobactam (C/T) in a high-risk population for antimicrobial resistance, specifically patients with cystic fibrosis (CF) and lung transplantation (LTx). Out of 163 clinical Pseudomonas aeruginosa isolates collected from a tertiary hospital in Melbourne, Australia, 81.6% were susceptible to C/T. Among the multidrug resistant (MDR) and extensively drug resistant (XDR) isolates, C/T showed susceptibility in 88.3% and 28.1% of cases, respectively. In conclusion, C/T maintained its activity against a significant portion of MDR and XDR P. aeruginosa isolates from CF and post-LTx patients.
Article
Transplantation
Jenny Li, Bradley J. Gardiner, Sanda Stankovic, Clare V. L. Oates, Yvonne Cristiano, Bronwyn J. Levvey, Andrew G. Brooks, Gregory I. Snell, Glen P. Westall, Lucy C. Sullivan
Summary: This study compared the effectiveness of two commercial assays (QFN-CMV and T-Track) in predicting the risk of CMV disease in lung transplant recipients. The results showed that both assays had good predictive ability for CMV replication in the blood, but were unable to predict CMV replication in the lung allograft.
TRANSPLANTATION DIRECT
(2023)
Article
Computer Science, Interdisciplinary Applications
Yashpal Ramakrishnaiah, Nenad Macesic, Geoffrey I. Webb, Anton Y. Peleg, Sonika Tyagi
Summary: The adoption of electronic health records (EHRs) has created opportunities for predicting clinical outcomes and improving patient care. However, non-standardized data representations and anomalies present major challenges in digital health research. To address these challenges, we have developed EHR-QC, a tool with two modules: data standardization and preprocessing. We believe that the development and adoption of tools like EHR-QC are critical for advancing digital health.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Microbiology
Yue Qu, David McGiffin, Lina Duque Sanchez, Thomas Gengenbach, Chris Easton, Helmut Thissen, Anton Y. Peleg
Summary: This study comprehensively assessed the anti-biofilm capability of the Carbothane driveline against leading microorganisms causing VAD driveline infections and explored its physicochemical characteristics. The Carbothane driveline demonstrated anti-biofilm activity, and the surface characteristics may explain its ability to inhibit biofilm formation.
Review
Microbiology
Jhih-Hang Jiang, David R. Cameron, Cara Nethercott, Marta Aires-de-Sousa, Anton Y. Peleg
Summary: This review focuses on the mechanisms that trigger the establishment and maintenance of current, dominant MRSA lineages across the globe. Factors that influence MRSA's ability to colonize and cause disease within a host are discussed, with an emphasis on colonization and niche adaptation. Understanding these mechanisms may lead to the development of targeted therapies.
CLINICAL MICROBIOLOGY REVIEWS
(2023)