Article
Nutrition & Dietetics
Guojun Wu, Hiba R. Tawfeeq, Atreju I. Lackey, Yinxiu Zhou, Zoe Sifnakis, Sophia M. Zacharisen, Heli Xu, Justine M. Doran, Harini Sampath, Liping Zhao, Yan Y. Lam, Judith Storch
Summary: This study investigated the effects of LFABP and IFABP deficiency on the gut microbiota in mice, and found that these changes were associated with phenotypic changes induced by a high-fat diet.
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Review
Medicine, General & Internal
Hangkai Huang, Chengfu Xu
Summary: Nonalcoholic fatty liver disease (NAFLD) is becoming more common as the global economy grows. Retinol-binding protein-4 (RBP4) has been found to be related to various metabolic diseases. However, observational studies on the association between serum RBP4 level and NAFLD prevalence have shown contradictory results. Further research should focus on the predictive value of RBP4 in NAFLD development and its potential as a therapeutic target.
CHINESE MEDICAL JOURNAL
(2022)
Article
Physiology
Ricardo Rodriguez-Calvo, Juan Moreno-Vedia, Josefa Girona, Daiana Ibarretxe, Neus Martinez-Micaelo, Jordi Merino, Nuria Plana, Lluis Masana
Summary: The study found that serum FABP4 is associated with liver steatosis in metabolic patients, suggesting its potential role in fatty liver disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Julia Nowowiejska, Anna Baran, Iwona Flisiak
Summary: This study discusses the role of fatty-acid-binding proteins (FABPs) in psoriasis and their potential as markers. Due to the different expressions and functions of FABPs in various tissues, they may be associated with psoriasis and its comorbidities.
Article
Biology
Neha Attal, Emilio Marrero, Kyle J. Thompson, Iain H. McKillop
Summary: Alcohol-induced metabolism through CYP2E1 inhibits AMPK alpha phosphorylation, leading to increased FFA accumulation and FABP4 protein secretion via an SREBP-1c dependent mechanism.
Article
Cell Biology
Liang-Ti Huang, Hsiu-Chu Chou, Chung-Ming Chen
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease in premature infants characterized by interrupted alveologenesis and alveolar simplification due to oxygen therapy. The study found that the FABP4 inhibitor BMS309403 can regulate pulmonary fibrotic processes in newborn rats exposed to hyperoxia, reducing lung fibrosis and expression of TGF-beta 1. The inhibition of FABP4 showed potential clinical and therapeutic applications in attenuating hyperoxia-induced lung impairments.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cell Biology
Peng Yuan, Jiao Mu, Zijun Wang, Shuaijun Ma, Xiuwei Da, Jian Song, Hongxin Zhang, Le Yang, Jibin Li, Jingyue Yang
Summary: SLC25A20 expression is frequently down-regulated in HCC cells due to the up-regulation of miR-132-3p, associated with a poor prognosis in patients. SLC25A20 suppresses HCC growth and metastasis by inhibiting cell transition, EMT, and inducing apoptosis. It may serve as a novel prognostic factor and therapeutic target for HCC patients.
CELL DEATH & DISEASE
(2021)
Review
Endocrinology & Metabolism
Rong Liu, Ming-Ping Qian, Ying-Yu Cui
Summary: Protein kinases (PKs) are a large protein family that can be divided into different groups based on their substrate or structure and function. They play important roles as signaling messengers in various life activities, including cell metabolism, proliferation, division, differentiation, senescence, death, and disease. Accumulating evidence suggests that PKs are involved in the pathogenesis of nonalcoholic fatty liver disease-derived hepatocellular carcinoma (NAFLD-HCC) through aberrant metabolism, hypoxia, autophagy, gut microbiota dysbiosis, and/or immune cell rearrangement. This review aims to summarize the latest research advances and highlight the feasibility and effectiveness of therapeutic strategies that regulate PKs.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Medicine, Research & Experimental
Yang Xiao, Lingling Shu, Xiaoping Wu, Yang Liu, Lai Yee Cheong, Boya Liao, Xiaoyu Xiao, Ruby L. C. Hoo, Zhiguang Zhou, Aimin Xu
Summary: The study reveals that elevated levels of FABP4 in patients with type 1 diabetes and their relatives are positively correlated with several islet autoantibodies. Inhibiting FABP4 expression can reduce the development of autoimmune diabetes in NOD mice, suggesting FABP4 plays a crucial role in activating innate and adaptive immune responses in islets.
Article
Gastroenterology & Hepatology
Manuel Rodriguez, Maria Luisa Gonzalez-Dieguez, Maria Varela, Valle Cadahia, Sara Maria Andres-Vizan, Alicia Mesa, Andres Castano, Carmen Alvarez-Navascues
Summary: Alcohol abstinence can reduce the risk of HCC in patients with alcohol-related cirrhosis, particularly in those without a history of decompensated disease. Early diagnosis of alcohol-related liver disease and strategies to achieve and maintain abstinence are crucial for this population.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giusy Tassone, Maurizio Orlandini, Massimo Olivucci, Cecilia Pozzi
Summary: Bile acids are hydroxylated steroids derived from cholesterol that facilitate nutrient absorption and act as signaling molecules, while bile acid-binding proteins mediate their trafficking in the liver, making them suitable for distributing various substances. Recombinant chicken liver BABP shows potential for drug carriers, nanotechnologies, and synthetic photoswitch systems after an efficient production, purification, and crystallization process. The study supports the use of recombinant cL-BABP for innovative applications in drug delivery and technology development.
Article
Multidisciplinary Sciences
Fumihito Hikage, Masato Furuhashi, Yosuke Ida, Hiroshi Ohguro, Megumi Watanabe, Soma Suzuki, Kaku Itoh
Summary: The study identified the presence of FABP4 and VEGFA in the vitreous fluid of RVO patients, with significantly higher levels in CRVO patients. Post-operatively, there was a correlation between FABP4 levels and VEGFA levels or MV-MT.
Article
Biotechnology & Applied Microbiology
Madison M. Mann, James D. Tang, Bryan W. Berger
Summary: PFAS are synthetic fluorinated chemicals with surface active and water-repellent properties that accumulate significantly in humans due to widespread use. A fluorescence-based biosensor designed using hLFABP allows for rapid detection of PFAS, demonstrating its usefulness in environmental water samples.
BIOTECHNOLOGY AND BIOENGINEERING
(2022)
Review
Pharmacology & Pharmacy
Kai Zhang, Anna E. Barry, Ryan Lamm, Keyur Patel, Michelle Schafer, Hien Dang
Summary: This review summarizes the roles of RNA-binding proteins (RBPs) in the development and progression of hepatocellular carcinoma (HCC). RBPs play a crucial role in promoting HCC progression and may have potential diagnostic and therapeutic implications for early diagnosis and prognosis of the disease.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)