Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Review
Psychiatry
Helene Gjervig Hansen, Helene Speyer, Marie Starzer, Nikolai Albert, Carsten Hjorthoj, Lene Falgaard Eplov, Merete Nordentoft
Summary: This study conducted a comprehensive analysis of previous research on individuals with schizophrenia and found a clinical recovery rate of approximately 21%. The study also found that the recovery rate was not significantly influenced by various factors, and there was no significant difference in recovery between early intervention services and other interventions. New initiatives are needed to improve the rate of recovery.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Psychiatry
Julie Ramain, Philippe Conus, Philippe Golay
Summary: This study aimed to consolidate current knowledge on first-episode affective psychoses and identify areas for further investigation. The results showed heterogeneity in diagnosis-related grouping under the concept of affective psychoses, indicating a need for specialized intervention for patients with different psychopathological and neurocognitive profiles.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Clinical
Gamze Erzin, Lotta-Katrin Pries, Stefanos Dimitrakopoulos, Irene Ralli, Lida-Alkisti Xenaki, Rigas-Filippos Soldatos, Ilias Vlachos, Mirjana Selakovic, Stefania Foteli, Ioannis Kosteletos, Nikos Nianiakas, Leonidas Mantonakis, Emmanouil Rizos, Konstantinos Kollias, Jim Van Os, Sinan Guloksuz, Nikos Stefanis
Summary: This study investigated the association between cumulative environmental risk for schizophrenia and functioning in individuals with first-episode psychosis. The results showed that cumulative environmental risk was associated with functioning, independent of other risk factors and symptom severity. Furthermore, functioning improved over time, but this improvement was not contingent on environmental risk.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Delbert G. Robinson, Nina R. Schooler, Patricia Marcy, Robert D. Gibbons, C. Hendricks Brown, Majnu John, Kim T. Mueser, David L. Penn, Robert A. Rosenheck, Jean Addington, Mary F. Brunette, Christoph U. Correll, Sue E. Estroff, Piper S. Mayer-Kalos, Jennifer D. Gottlieb, Shirley M. Glynn, David W. Lynde, Susan Gingerich, Ronny Pipes, Alexander L. Miller, Joanne B. Severe, John M. Kane
Summary: This study examined the long-term effects of early intervention services for first-episode psychosis. The results showed that compared to community care, early intervention services significantly improved patients' quality of life and symptoms, and reduced the number of hospitalization days.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Psychiatry
Claire Maechling, Antoine Yrondi, Amandine Cambon
Summary: The purpose of this systematic literature review is to evaluate the therapeutic efficacy of mobile health methods in managing patients with first-episode psychosis. The participants were patients with first-episode psychosis, and the interventions included smartphone applications. The studies assessed the preliminary efficacy of various types of applications. The results showed that mobile applications have potential value in managing young patients with first-episode psychosis, reducing relapses, emergency department visits, and hospital admissions through the use of various assessment and intervention tools.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Kathryn Albin, Cameron Albin, Clark D. Jeffries, Diana O. Perkins
Summary: The study found that 38% of subjects were not diagnosed with a psychotic disorder in their initial episode of care. The time to diagnosis for psychosis was similar for subjects that did and did not receive a diagnosis. Care episodes without a psychosis diagnosis more often involved outpatient and mental health services, but dangerousness indicators were similar.
JOURNAL OF ADOLESCENT HEALTH
(2021)
Review
Psychiatry
Ana Catalan, Anja Richter, Gonzalo Salazar de Pablo, Julio Vaquerizo-Serrano, Gonzalo Mancebo, Borja Pedruzo, Claudia Aymerich, Marco Solmi, Miguel A. Gonzalez-Torres, Patxi Gil, Philip McGuire, Paolo Fusar-Poli
Summary: The study found that approximately half of patients experience symptomatic remission around four years after FEP, while about a third show recovery after 5.5 years. No significant effects of sociodemographic or clinical predictors were found.
EUROPEAN PSYCHIATRY
(2021)
Review
Psychiatry
Giacomo Ciocca, Tommaso B. Jannini, Michele Ribolsi, Rodolfo Rossi, Cinzia Niolu, Alberto Siracusano, Emmanuele A. Jannini, Giorgio Di Lorenzo
Summary: A considerable amount of literature indicates that individuals with psychotic disorders often experience sexual dysfunctions, possibly due to long-term use of antipsychotic drugs. Research focusing on sexuality in ultra-high risk and first-episode psychosis reveals the impact of sexual dysfunctions during the transition period of illness.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Kim T. Mueser, Rachel F. Sussman, Nicole R. Detore, Elizabeth S. Eberlin, Susan R. Mcgurk
Summary: Impaired cognitive functioning is a core feature of schizophrenia, and early intervention services have been shown to improve symptoms and functioning in first episode psychosis. This study evaluated the long-term effects of early intervention services on cognitive functioning in first episode psychosis patients. The results showed that while there were no improvements in cognitive functioning for older patients, younger patients showed significant improvements in working memory. Overall, interventions targeting cognition may be necessary to enhance cognitive functioning in most first episode psychosis patients.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Psychiatry
Oihane Mentxaka, Maria Recio-Barbero, Eunate Arana-Arri, Rafael Segarra
Summary: Patients with first-episode psychosis (FEP) are not more likely to be involved in crimes than the general population. The types of violent acts committed by individuals with FEP are diverse, with extreme violence being uncommon.
Review
Clinical Neurology
Ariana J. Cahn, Kamyar Keramatian, Christian Frysch, Lakshmi N. Yatham, Trisha Chakrabarty
Summary: Studies on grey matter changes in patients with bipolar I disorder following the first episode of mania show inconsistent results, with some suggesting that ACC volume decrease may be a marker for neuroprogression. However, the findings are not conclusive and larger studies are needed to better understand neuroprogression in early BD-I.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Antonio Melillo, Edoardo Caporusso, Giulia Maria Giordano, Luigi Giuliani, Pasquale Pezzella, Andrea Perrottelli, Paola Bucci, Armida Mucci, Silvana Galderisi, Jean-Arthur Micoulaud Franchi
Summary: This review aims to explore the correlations between negative symptoms and deficits in neurocognition and social cognition in individuals with first-episode psychosis and at-risk populations. The available evidence suggests that negative symptoms are associated with executive functioning and theory of mind deficits in first-episode psychosis subjects, and with deficits in processing speed, attention, vigilance, and working memory in at-risk populations.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Endocrinology & Metabolism
Claudia Aymerich, Borja Pedruzo, Malein Pacho, Marta Laborda, Jon Herrero, Toby Pillinger, Robert A. McCutcheon, Daniel Alonso-Alconada, Marta Bordenave, Maria Martinez-Querol, Ainara Arnaiz, Javier Labad, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres, Ana Catalan
Summary: Alterations in prolactin and cortisol levels have been found in antipsychotic naive patients with first episode psychosis. This study aims to provide estimates for the standardized mean differences and inter-group variability of these hormone levels in this patient group compared to healthy controls.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Psychiatry
Pei Ling Lim, Roselyne Shirley Pat Fong
Summary: This study provides a brief overview of young people presenting with first episode psychosis at a paediatric hospital in Singapore over the course of a year. It highlights the importance of joint initial assessment by paediatricians and child psychiatrists in determining clinical characteristics and guiding treatment decisions. Stigma and cultural beliefs were also identified as factors affecting delay in presentation and adherence to treatment.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Review
Psychiatry
Jayleigh Lim, Geoff McCombe, Aine Harrold, Katherine Brown, Mary Clarke, David Hanlon, Liam Hennessy, Sinead O'Brien, John Lyne, Ciaran Corcoran, Patrick McGorry, Walter Cullen
Summary: This study examined 27 studies from 10 countries and found that key workers can enhance physical health outcomes in first episode psychosis (FEP) patients by addressing factors associated with increased mortality. Key workers primarily mediated improvements in psychosis-induced effects and reduction of organizational barriers to improve survival rates in FEP patients. Further research on key worker interventions in this population is needed.
EARLY INTERVENTION IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Brian O'Donoghue, John Lyne, Eric Roche, Nathan Mifsud, Laoise Renwick, Caragh Behan, Mary Clarke
Summary: This study found that migrants from Africa have a nearly twofold increased risk of developing a psychotic disorder compared to those born in the Republic of Ireland, while migrants from certain Asian countries have a reduced risk. Further research into the factors behind this increased risk in specific migrant groups could provide insights into the cause of psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Donal O'Keeffe, Ann Sheridan, Aine Kelly, Roisin Doyle, Kevin Madigan, Elizabeth Lawlor, Mary Clarke
Summary: This study aimed to explore how individuals perceive personal recovery 20 years after their first-episode psychosis, and to investigate the potential influence of clinical recovery status on their definitions of recovery. Findings highlight the role of time in conceptualising personal recovery and suggest that clinical recovery may impact the meaning of personal recovery in FEP in mid-later life.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2022)
Article
Psychiatry
John Broughan, Geoff McCombe, Jayleigh Lim, Donal O'Keeffe, Katherine Brown, Mary Clarke, Ciaran Corcoran, David Hanlon, Ned Kelly, John Lyne, Patrick McGorry, Sinead O' Brien, Karen O' Connor, Karen O' Mahony, Seamus Scott, Elizabeth Wycherley, Walter Cullen
Summary: This study evaluated a keyworker-mediated intervention promoting physical health among first episode psychosis patients, finding mixed feasibility outcomes and highlighting challenges such as low recruitment rates, variable linkages between keyworkers and general practitioners, and the impact of COVID-19 restrictions.
EARLY INTERVENTION IN PSYCHIATRY
(2022)
Article
Psychiatry
Donal O'Keeffe, David Marshall, Andrew Wheeler, Eoghan Allen, Helena Ronan, Amy Buckley, Eimear Counihan, Mary Clarke
Summary: The article introduces a multidisciplinary, blended, telehealth intervention called PERCEPTION, which is designed for family members of first episode psychosis service users. By describing the development and implementation of PERCEPTION, reflecting on clinicians' experiences, offering recommendations for future research, and synthesizing key learning, the article aims to assist the integration of similar interventions in other EIP services.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Donal O'Keeffe, Anthony Kinsella, John L. Waddington, Mary Clarke
Summary: Determining the relationship between the duration of untreated psychosis (DUP) and long-term outcomes requires prospective studies of incidence cohorts over several decades. This study followed an Irish first-episode psychosis cohort for 20 years and found that shorter DUP was associated with improved symptoms, functioning, and quality of life, although the associations differed across outcome domains.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Letter
Medicine, General & Internal
Donal O'Keeffe, Mary Clarke
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Letter
Psychiatry
Donal O'Keeffe, Anthony Kinsella, John L. Waddington, Mary Clarke
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Review
Medicine, General & Internal
Sean Naughton, Mary Clarke
Summary: The transition from higher training to consultanthood is crucial, but new consultants often feel unprepared for their clinical and non-clinical duties. Post-CSCST fellowships play an important role in meeting the non-clinical training needs of new consultants.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Psychiatry
Brian O'Donoghue, Eric Roche, John Lyne, Laoise Renwick, Mary Clarke
Summary: Migration is a strong risk factor for developing a psychotic disorder, but there is limited research on the outcomes of migrants with a psychotic disorder. This study aimed to evaluate various outcomes for migrants with first episode psychosis (FEP) in Ireland. The results showed that migrants had similar outcomes to the native-born populations, highlighting the need to improve outcomes for all individuals affected by psychotic disorders.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Psychiatry
B. O'Donoghue, S. Sexton, J. P. Lyne, E. Roche, N. Mifsud, E. Brown, L. Renwick, C. Behan, M. Clarke
Summary: This study explores the demographic and clinical characteristics of migrants with first episode of psychosis (FEP) compared to the native-born population in an Irish Early Intervention for Psychosis service. The findings show that migrants have similar characteristics to the native-born population, except for less insight in migrants from Africa and a higher proportion of involuntary admissions in the total migrant group.
IRISH JOURNAL OF PSYCHOLOGICAL MEDICINE
(2023)
Meeting Abstract
Psychiatry
R. Rowntree, F. Fanning, D. Keating, S. Murray, A. Szigeti, R. Doyle, S. Mcwilliams, M. Clarke
EUROPEAN PSYCHIATRY
(2021)
Article
Medicine, General & Internal
Dolores Keating, Stephen McWilliams, Fiona Boland, Roisin Doyle, Caragh Behan, Judith Strawbridge, Mary Clarke
Summary: The study found that with changing clinical guidelines and the development of mental health services, the pattern of antipsychotic drug use in first-episode psychosis patients has changed, with a preference for second-generation antipsychotics, however, in choosing olanzapine, the recommended initial dosage is often overlooked.