Targeting cartilage EGFR pathway for osteoarthritis treatment

Manganese dioxide nanoparticles protect cartilage from inflammation-induced oxidative stress

(2019) Shreedevi Kumar et al.   BIOMATERIALS

Block Copolymer Micelles in Nanomedicine Applications

(2018) Horacio Cabral et al.   CHEMICAL REVIEWS

Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Spencer L James et al.   LANCET

Cartilage-penetrating nanocarriers improve delivery and efficacy of growth factor treatment of osteoarthritis

(2018) Brett C. Geiger et al.   Science Translational Medicine

Nanoindentation modulus of murine cartilage: a sensitive indicator of the initiation and progression of post-traumatic osteoarthritis

(2017) B. Doyran et al.   OSTEOARTHRITIS AND CARTILAGE

Loading-Induced Reduction in Sclerostin as a Mechanism of Subchondral Bone Plate Sclerosis in Mouse Knee Joints During Late-Stage Osteoarthritis

(2017) Haoruo Jia et al.   Arthritis & Rheumatology

Cyclic Mechanical Loading Enhances Transport of Antibodies Into Articular Cartilage

(2016) Chris D. DiDomenico et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury

(2016) Huimin Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR signaling is critical for maintaining the superficial layer of articular cartilage and preventing osteoarthritis initiation

(2016) Haoruo Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

­­­­­Insulin-Like Growth Factor II (IGF-II) Inhibits IL-1β-Induced Cartilage Matrix Loss and Promotes Cartilage Integrity in Experimental Osteoarthritis

(2015) Tomoya Uchimura et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities

(2015) D.L. Long et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of aPrg4-Expressing Articular Cartilage Progenitor Cell Population in Mice

(2015) Elena Kozhemyakina et al.   Arthritis & Rheumatology

Nanomechanical phenotype of chondroadherin-null murine articular cartilage

(2014) Michael A. Batista et al.   MATRIX BIOLOGY

Cartilage-specific deletion of Mig-6 results in osteoarthritis-like disorder with excessive articular chondrocyte proliferation

(2014) B. Staal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From wavy hair to naked proteins: The role of transforming growth factor alpha in health and disease

(2014) Bhuminder Singh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Facile Method for the Site-Specific, Covalent Attachment of Full-Length IgG onto Nanoparticles

(2014) James Zhe Hui et al.   Small

Disturbed Cartilage and Joint Homeostasis Resulting From a Loss of Mitogen-Inducible Gene 6 in a Mouse Model of Joint Dysfunction

(2014) Michael A. Pest et al.   Arthritis & Rheumatology

Gold-Loaded Polymeric Micelles for Computed Tomography-Guided Radiation Therapy Treatment and Radiosensitization

(2013) Ajlan Al Zaki et al.   ACS Nano

Sortase-Tag Expressed Protein Ligation: Combining Protein Purification and Site-Specific Bioconjugation into a Single Step

(2013) Robert Warden-Rothman et al.   ANALYTICAL CHEMISTRY

Epidermal growth factor receptor targeting in cancer: A review of trends and strategies

(2013) Chetan Yewale et al.   BIOMATERIALS

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Epiphyseal Cartilage Development through β-Catenin-dependent and -independent Pathways

(2013) Xianrong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epidermal Growth Factor Receptor (EGFR) Signaling Promotes Proliferation and Survival in Osteoprogenitors by Increasing Early Growth Response 2 (EGR2) Expression

(2013) Abhishek Chandra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ErbB/HER family of protein-tyrosine kinases and cancer

(2013) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo

(2013) John B Shepard et al.   ARTHRITIS RESEARCH & THERAPY

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Isolation and Characterization of Multipotential Mesenchymal Cells from the Mouse Synovium

(2012) Ippei Futami et al.   PLoS One

Onset of preclinical osteoarthritis: The angular spatial organization permits early diagnosis

(2011) Bernd Rolauffs et al.   ARTHRITIS AND RHEUMATISM

Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis

(2011) E. R. Sampson et al.   Science Translational Medicine

Loss of cartilage structure, stiffness, and frictional properties in mice lacking PRG4

(2010) Jeffrey M. Coles et al.   ARTHRITIS AND RHEUMATISM

Cartilage cell clusters

(2010) Martin K. Lotz et al.   ARTHRITIS AND RHEUMATISM

Histopathology atlas of animal model systems – overview of guiding principles

(2010) T. Aigner et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse

(2010) S.S. Glasson et al.   OSTEOARTHRITIS AND CARTILAGE

Articular Cartilage: Structure and Regeneration

(2010) José Becerra et al.   TISSUE ENGINEERING PART B-REVIEWS

Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin

(2009) Carl R. Flannery et al.   ARTHRITIS AND RHEUMATISM

Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage

(2009) Stephen P. Henry et al.   GENESIS

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach