Article
Biochemistry & Molecular Biology
Margaret A. Wangeline, Randolph Y. Hampton
Summary: HMG-CoA reductase undergoes feedback-regulated degradation as part of sterol pathway control. The study revealed that the Hmg2 SSD is critical for regulated degradation of Hmg2 and required for mallosteric misfolding of GGPP.INSIG proteins modulate the function of Hmg2 SSD, imposing a second layer of control on Hmg2 regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Engineering, Geological
Francisco J. Pinto, Shideh Dashti, Christian Ledezma, Jose A. Abell
Summary: The construction of tall buildings in major cities has grown exponentially, presenting new challenges in earthquake engineering and design. Existing procedures for evaluating seismic lateral earth pressures on basement walls connected to these buildings typically ignore the inertia and dynamic properties of the superstructure.
SOIL DYNAMICS AND EARTHQUAKE ENGINEERING
(2023)
Editorial Material
Biology
Maggie R. Wagner
Summary: This statement describes the influence of maize genes on recruiting bacterial species from the soil, particularly in the absence of nitrogen fertilizer.
Article
Polymer Science
Russell K. W. Spencer, Bae-Yeun Ha
Summary: Inclusions in a brush disrupt the brush structure and introduce effective particle-particle interactions mediated by the brush. The brush promotes clustering of inclusions when the grafting point is mobile, while inclusions tend to be dispersed when the grafting point is fixed. These findings have biological implications for interactions between antimicrobial peptides and bacterial lipopolysaccharides, as well as clustering of integrin on cancerous cell membranes.
Article
Agriculture, Multidisciplinary
Hongxia Tan, Hongyuan Zhou, Ting Guo, Ying Zhou, Yuhao Zhang, Ruo Yuan, Liang Ma
Summary: The study found that thermal processing decreases the interaction between zein and zearalenone (ZEN), leading to the release of ZEN. This is important for improving the risk assessment of ZEN in maize-based products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Xiao-Yu Li, Ying Zou, Song-De Han, Guo-Ming Wang
Summary: This study constructed two novel Fe clusters, Fe-6 and Fe-18, with different structural models based on a rare H(5)thmmg ligand. The transition from Fe-6 to Fe-18 was successfully achieved by adding more triethylamine, leading to nuclearity enlargement and structural regulation. Additionally, both Fe-6 and Fe-18 clusters exhibit antiferromagnetism, providing insights for the structural predesign and adjustment of metal nanoclusters.
INORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Genta Ito, Taisuke Tomita, Naoko Utsunomiya-Tate
Summary: In this study, it was found that the abnormal increase in phosphorylation of Rab12 by LRRK2 is attributed to the structural differences caused by the bound nucleotide, and that Rab12 phosphorylation inhibits its activation. The research also showed that Rab12 in its GDP-bound form is more susceptible to heat-induced denaturation and has a lower thermal stability compared to its GTP-bound form. These findings provide insights into unraveling the mechanism behind the abnormal increase in Rab12 phosphorylation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jie Yang, Ping Shang, Hui Yuan, Ling Song, Qing Huang, Zihao Jiang, Can Wu, Xuanfeng Jiang
Summary: In this study, we successfully synthesized two host-guest-encapsulated cuprous iodide cluster-based supramolecular architectures using flexible ligands. These structures exhibited tunable luminescent properties and demonstrated high photocatalytic activity.
CRYSTAL GROWTH & DESIGN
(2022)
Article
Chemistry, Applied
Jie Liu, Yiman Zhang, Jiayuan Liu, Huijuan Zhang, Lingxiao Gong, Zhaofeng Li, Hongzhi Liu, Ziyuan Wang
Summary: This study investigated the effects of epigallocatechin-3-gallate (EGCG), chlorogenic acid (CA), piceatannol (PIC) and ferulic acid (FA) on the conformational and functional properties of wheat germ protein (WGP). The findings suggest that EGCG has the highest binding affinity to WGP, and polyphenols change the secondary and tertiary structure of WGP, leading to improved solubility and functionality.
FOOD HYDROCOLLOIDS
(2024)
Article
Neurosciences
Silvia Perzolli, Arianna Bentenuto, Giulio Bertamini, Paola Venuti
Summary: This study compared the interactive behaviors of fathers and mothers with their children with ASD during play activities. The results showed that mothers engaged more in symbolic play, while fathers displayed higher levels of exploratory play. However, child cognitive functioning only impacted maternal play, not paternal play characteristics.
Review
Neurosciences
Katrina A. Black, Ruitao Jin, Sitong He, Jacqueline M. Gulbis
Summary: The primary means for controlling ion permeation through potassium channels is the switching between non-conducting and conducting states. While traditionally explained by a steric mechanism, some classes of K+ channels may have 'non-canonical' mechanisms. The review aims to illuminate the structural and dynamic relationships underlying permeation control in K+ channels.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Education & Educational Research
Shiyan Jiang, Blaine E. Smith, Ji Shen
Summary: This study examines how different modes mediate students' interactions in creating multimodal science fictions as they work in small groups. Findings show that students tend to provide short responses to continue composing practices, and group discussions during multimodal composing go through three stages, with different modes supporting self-oriented and group-oriented contributions uniquely.
INTERACTIVE LEARNING ENVIRONMENTS
(2021)
Article
Public, Environmental & Occupational Health
Johannes Carl, Eva Gruene, Klaus Pfeifer
Summary: Research in the field has led to the development of various frameworks, models, and theories to understand physical activity levels. The PAHCO model, situated between health literacy and physical activity research, has yet to address the role of the environment. The article suggests three potential solutions for enhancing the relevance of the PAHCO model, including integration, elaboration, and extension, to better incorporate environmental factors into the model.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Health Care Sciences & Services
Jan Domaradzki, Marcin Piotr Walkowiak, Dariusz Walkowiak, Gilbert Ramirez
Summary: This study investigated the correlation between medical and healthcare students' willingness to donate biospecimens, the type of tissues to be donated, and the type of biomedical research to be conducted. The findings suggest that cluster thinking can predict people's readiness to participate in the collection and management of biospecimens.
Article
Engineering, Civil
Gonzalo Barrios, Tam Larkin, Nawawi Chouw
Summary: This study investigated the effect of distance on interaction between adjacent structures and the impact of neighboring buildings on the dynamic properties of a structure through experiments on single degree-of-freedom structures in a sand-filled laminar box. The research found that as the number of participating structures increased, the fundamental frequency also increased, with the damping ratio being significantly influenced by the soil, achieving the lowest damping ratio with an intermediate number of structures.
INTERNATIONAL JOURNAL OF STRUCTURAL STABILITY AND DYNAMICS
(2021)
Review
Biochemistry & Molecular Biology
Xuelan Wu, Renhong Yan, Pingping Cao, Hongwu Qian, Nieng Yan
Summary: This article summarizes recent structural and mechanistic investigations of sterol-sensing domain (SSD)-containing proteins and proposes to divide them into moderators and transporters.
TRENDS IN BIOCHEMICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Tian Xie, Zike Zhang, Jian Yue, Qi Fang, Xin Gong
Summary: The ATP-binding cassette transporter ABCA3 plays a critical role in pulmonary surfactant synthesis. Mutations in human ABCA3 are the most common cause of inherited surfactant dysfunction disorders. This study presents the cryo-EM structures of human ABCA3 in two conformations and reveals a potential substrate binding mechanism and a conserved lateral access and extrusion mechanism for lipid transport mediated by ABCA transporters.
Article
Multidisciplinary Sciences
Yingying Guo, Yuanyuan Zhang, Renhong Yan, Bangdong Huang, Fangfei Ye, Liushu Wu, Ximin Chi, Yi Shi, Qiang Zhou
Summary: This study reports the structures of human NKA, providing insights into the cytoplasmic Na+ entrance pathway and the mechanism of cytoplasmic gate closure coupled with ATP hydrolysis. This fills crucial gaps in understanding the working cycle of NKA.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ryan Keable, Shangfeng Hu, Grant Pfundstein, Irina Kozlova, Feifei Su, Ximing Du, Hongyuan Yang, Jenny Gunnersen, Melitta Schachner, Iryna Leshchyns'ka, Vladimir Sytnyk
Summary: The association between NCAM2 and BACE1 promotes the targeting of BACE1 to endosomes, thereby regulating its activity.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Isabelle M. Capell-Hattam, Nicole M. Fenton, Hudson W. Coates, Laura J. Sharpe, Andrew J. Brown
Summary: In this study, researchers identified the noncatalytic protein ERG28 as a player in mammalian cholesterol synthesis. They found that ERG28 is transcriptionally regulated by the transcription factor SREBP-2 and interacts with enzymes involved in cholesterol synthesis. Knockout of ERG28 resulted in reduced cholesterol levels and impaired cholesterol synthesis. Additionally, ERG28 knockout also affected the activation of SREBP-2 under sterol-replete conditions. These findings highlight the importance of ERG28 in cholesterol synthesis and suggest that further understanding of this protein could contribute to therapeutic strategies for diseases associated with aberrant cholesterol metabolism.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Cell Biology
Ivan Lukmantara, Fang Chen, Hoi Yin Mak, Armella Zadoorian, Ximing Du, Fanqian Nicole Xiao, Dougall MacMurray Norris, Elvis Pandzic, Renee Whan, Qing Zhong, Hongyuan Yang
Summary: In this study, we identified PI(3)P as a novel regulator of lipid droplet (LD) biogenesis, which impacts LD formation and lipidation through DFCP1. Disruption of cellular PI(3)P homeostasis affects the normal function and localization of DFCP1.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Biology
Hudson W. Coates, Isabelle M. Capell-Hattam, Ellen M. Olzomer, Ximing Du, Rhonda Farrell, Hongyuan Yang, Frances L. Byrne, Andrew J. Brown
Summary: Cholesterol synthesis is an energy- and oxygen-intensive process, but the regulatory effects of hypoxia on pathway enzymes are not well understood. Researchers have discovered that hypoxia triggers the truncation of the rate-limiting enzyme squalene monooxygenase (SM), allowing it to maintain activity and pathway flux. This mechanism involves increased proteasomal degradation of SM and accumulation of its substrate squalene. These findings provide insights into how SM accommodates fluctuating substrate levels and may contribute to its oncogenic properties.
Article
Oncology
Ximing Liu, Xinxin Tian, Xinyan Hao, Huixiang Zhang, Kailun Wang, Zhizhong Wei, Xin Wei, Yulu Li, Jianhua Sui
Summary: The study successfully developed pH-dependent anti-EGFR antibodies with cross-species reactivity, demonstrating their tumor-selective binding to EGFR under acidic conditions and potential to overcome limitations of antibody binding to normal tissues.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Engineering, Biomedical
Xinxin Tian, Ximing Liu, Jingjin Ding, Fengchao Wang, Kailun Wang, Juan Liu, Zhizhong Wei, Xinyan Hao, Yulu Li, Xin Wei, Huixiang Zhang, Jianhua Sui
Summary: An anti-CD98 antibody with pH-dependent binding has been found to elicit broad-spectrum anti-tumour activity in CD98-humanized mice. This discovery suggests that pH-dependent antibody variants targeting CD98 may have superior therapeutic outcomes.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Virology
Yaning Li, Yaping Shen, Yuanyuan Zhang, Renhong Yan
Summary: The Omicron variants of SARS-CoV-2, characterized by numerous spike protein mutations, have become the dominant strains globally. Cryo-EM structures of the trimeric S proteins from different Omicron subvariants (BA.1, BA.2, BA.3, and BA.4/BA.5) in complex with ACE2 receptor were determined. The S protein conformations varied among subvariants, correlating with their transmissibility and immune evasion mechanisms. Understanding the molecular basis of Omicron's infectivity and immune evasion is crucial for developing effective therapeutic interventions against SARS-CoV-2 variants.
Article
Multidisciplinary Sciences
Zhenhua Wang, Meng Yang, Yufan Yang, Yonglin He, Hongwu Qian
Summary: This study presents the cryo-EM structures of human CEPT1 and its complex with CDP-choline, revealing a hydrophobic chamber involved in catalysis. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are vital components of eukaryotic membranes and have various important roles. The structures of CEPT1 and its complex provide insights into the catalytic mechanism and potential substrate-triggered product release.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yaning Li, Yaping Shen, Ziwei Hu, Renhong Yan
Summary: The ongoing global pandemic caused by a variant of the monkeypox virus has raised concerns. The structure and mechanism of the DNA polymerase holoenzyme of the virus remains elusive, but recent research has provided insights into its assembly and functioning. These findings are important for developing targeted antiviral therapies.
Letter
Cell Biology
Xia Yao, Shuai Gao, Nieng Yan
Letter
Cell Biology
Renhong Yan, Enjun Xie, Yaning Li, Jin Li, Yuanyuan Zhang, Ximin Chi, Xueping Hu, Lei Xu, Tingjun Hou, Brent R. Stockwell, Junxia Min, Qiang Zhou, Fudi Wang
