Ribosome profiling analysis of human skeletal muscle identifies reduced translation of mitochondrial proteins with age

Discovery proteomics in aging human skeletal muscle finds change in spliceosome, immunity, proteostasis and mitochondria

(2019) Ceereena Ubaida-Mohien et al.   eLife

Skeletal muscle ex vivo mitochondrial respiration parallels decline in vivo oxidative capacity, cardiorespiratory fitness, and muscle strength: The Baltimore Longitudinal Study of Aging

(2018) Marta Gonzalez-Freire et al.   AGING CELL

Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

(2018) Gregory M Solis et al.   eLife

Transcriptome-wide measurement of translation by ribosome profiling

(2017) Nicholas J. McGlincy et al.   METHODS

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Systematic discovery of cap-independent translation sequences in human and viral genomes

(2016) Shira Weingarten-Gabbay et al.   SCIENCE

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

A comprehensive assessment of mitochondrial protein synthesis and cellular proliferation with age and caloric restriction

(2011) Benjamin F. Miller et al.   AGING CELL

Human mitochondrial mRNAs—like members of all families, similar but different

(2010) Richard J. Temperley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

(2010) Fabio Demontis et al.   CELL

A midlife longevity drug?

(2009) Matt Kaeberlein et al.   NATURE

Mutation in TACO1, encoding a translational activator of COX I, results in cytochrome c oxidase deficiency and late-onset Leigh syndrome

(2009) Woranontee Weraarpachai et al.   NATURE GENETICS