期刊
PSYCHIATRY RESEARCH
卷 295, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2020.113568
关键词
Interleukin-1 beta; Tumor necrosis factor-alpha; Major depressive disorder
类别
The study found that serum IL-1 beta and TNF-alpha levels are increased in MDD patients and are positively correlated with the severity of depression. Elevated levels of serum IL-1 beta and TNF-alpha could potentially be used as risk assessment indicators for depression.
Major depressive disorder (MDD) is a debilitating psychiatric disease. The dysregulated cytokines in depression are assumed due to the hyperactivation of the immune system. Here we aimed to evaluate the serum interleukin1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in MDD. This study recruited 87 MDD patients and 87 age and sex matched healthy controls (HCs). The increased levels of serum IL-1 beta and TNF-alpha were observed among MDD patients. These higher levels of peripheral markers were positively correlated with the severity of depression. Therefore, the elevated levels of serum IL-1 beta and TNF-alpha might be used as risk assessment indicators for depression.
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