期刊
PROGRESS IN LIPID RESEARCH
卷 81, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.plipres.2020.101083
关键词
Astaxanthin; Metabolic engineering; Synthetic biology; Carotenoid
资金
- Chinese Academy of Agricultural Sciences [Y2020XK25, CAAS-XTCX2018020-7, CAAS-ASTIP-2016-OCRI, K159]
- Ministry of Science and Technology of the China [2016YFD0501209]
This review focuses on the strategies of reprogramming microorganisms for astaxanthin production via metabolic engineering, with a primary discussion on the applications of synthetic biology, enzyme engineering, and metabolic engineering in this field. The article also summarizes the biosynthetic pathways of astaxanthin within natural producers, as well as achievements and challenges in enhancing astaxanthin production in microorganisms.
There is an increasing demand for astaxanthin in food, feed, cosmetics and pharmaceutical applications because of its superior anti-oxidative and coloring properties. However, naturally produced astaxanthin is expensive, mainly due to low productivity and limited sources. Reprogramming of microorganisms for astaxanthin production via metabolic engineering is a promising strategy. We primarily focus on the application of synthetic biology, enzyme engineering and metabolic engineering in enhancing the synthesis and accumulation of astaxanthin in microorganisms in this review. We also discuss the biosynthetic pathways of astaxanthin within natural producers, and summarize the achievements and challenges in reprogramming microorganisms for enhancing astaxanthin production. This review illuminates recent biotechnological advances in microbial production of astaxanthin. Future perspectives on utilization of new technologies for boosting microbial astaxanthin production are also discussed.
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