Article
Biochemistry & Molecular Biology
Rahim Ullah, Gowhar Ali, Ajmal Khan, Sajjad Ahmad, Ahmed Al-Harrasi
Summary: The study investigated the effects of 3NCP on AD using 5xFAD mouse models, showing potential therapeutic effects in reducing amyloid plaques and improving learning and memory. In vivo studies demonstrated that 3NCP did not induce anxiety, significantly reduced beta-amyloid plaques, and decreased BACE-1 expression in the brain tissues. This suggests that 3NCP may be a promising candidate for future AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Insup Choi, Minghui Wang, Seungyeul Yoo, Peng Xu, Steven P. Seegobin, Xianting Li, Xian Han, Qian Wang, Junmin Peng, Bin Zhang, Zhenyu Yue
Summary: Choi et al. demonstrate that autophagy is activated in microglia, particularly in disease-associated microglia surrounding amyloid plaques in Alzheimer's disease mouse models. Blocking microglial autophagy worsens neuropathology in AD mice. Dysfunction in autophagy has been implicated in the pathogenesis of AD, and previous studies have shown disruptions in autophagy-lysosomal pathway in affected neurons. However, the role of deregulated autophagy in microglia, a cell type associated with AD, and its contribution to disease progression, remained unclear.
NATURE CELL BIOLOGY
(2023)
Article
Chemistry, Medicinal
Clayton A. Whitmore, Justin R. Haynes, William J. Behof, Adam J. Rosenberg, Mohammed N. Tantawy, Brian C. Hachey, Brian E. Wadzinski, Benjamin W. Spiller, Todd E. Peterson, Krista C. Paffenroth, Fiona E. Harrison, Robert B. Beelman, Printha Wijesinghe, Joanne A. Matsubara, Wellington Pham
Summary: The study assessed the effects of ERGO consumption on the progression of Alzheimer's disease in young 5XFAD mice. The results showed that ERGO could reduce amyloid plaques, oxidative stress, and restore glucose metabolism. The study also highlights the importance of imaging technology in evaluating treatment response.
Article
Biochemistry & Molecular Biology
DaWon Kim, Gi Hun Bae, Hye Yun Kim, Hanna Jeon, Kyeonghwan Kim, Jisu Shin, Sunhee Lee, Seungpyo Hong, Ikyon Kim, YoungSoo Kim
Summary: The study showed that YB-9 administration in a mouse model reduced Aβ oligomers and plaques in the hippocampus, leading to decreased astrogliosis and improved synaptic dysfunction.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Sharay E. Setti, James Raymick, Joseph Hanig, Sumit Sarkar
Summary: A new method for rapid and thorough amyloid plaque labeling using Congo Red via perfusion has been introduced, resulting in reduced labeling time and variability in staining procedures.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Christopher Liang, Grace A. Nguyen, Tram B. Danh, Anoopraj K. Sandhu, Lusine L. Melkonyan, Amina U. Syed, Jogeshwar Mukherjee
Summary: The effects of Aβ plaques on nicotinic acetylcholine receptors (nAChRs) alpha 4 beta 2* subtype were studied using the transgenic 5xFAD mouse model of Alzheimer's disease (AD).
Review
Nanoscience & Nanotechnology
Piper A. Rawding, Jiyoon Bu, Jianxin Wang, Da Won Kim, Adam J. Drelich, Youngsoo Kim, Seungpyo Hong
Summary: Cancer immunotherapy utilizes the patient's immune system to treat cancer, but currently, it is only effective in a small subset of patients. Nanoparticles have been used as carriers for immunotherapeutic drugs, showing robust anti-tumor effects.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
A-Hyeon Lee, Sung-Chul Hong, Inwook Park, Soljee Yoon, YoungSoo Kim, Jinsik Kim, Seung-Hoon Yang
Summary: The fluorescence chemical dye fucoxanthin is capable of detecting Aβ aggregates in the brain tissue of AD transgenic mouse models, making it a valuable tool for AD diagnosis. This study found that fucoxanthin from the microalgae P. tricornutum has specific excitation and emission wavelengths for detecting Aβ aggregates without interference. The colocalization of fucoxanthin-positive and thioflavin S-positive stained regions in the brain tissue confirms the potential of fucoxanthin as a new Aβ fluorescent imaging reagent in AD diagnosis.
APPLIED SCIENCES-BASEL
(2021)
Review
Nanoscience & Nanotechnology
Michael J. Poellmann, Piper Rawding, DaWon Kim, Jiyoon Bu, YoungSoo Kim, Seungpyo Hong
Summary: The development of minimally invasive tests for cancer diagnosis and prognosis, such as liquid biopsies, face challenges in isolating and detecting cancerous material from routine blood samples. This review discusses the use of branched and hyperbranched polymers to improve the performance of liquid biopsy devices, enhancing sensitivity, specificity, and signal amplification. Further advancements in hyperbranched polymers in liquid biopsy applications will enhance device capabilities and help these critical technologies reach the oncology clinic.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Donghee Lee, Hyunjin Vincent Kim, Hye Yun Kim, YoungSoo Kim
Summary: In this study, brain-to-blood efflux of Aβ in AD transgenic mice was stimulated by orally administrating a chemical, and the altered levels of blood Aβ showed potential as an amyloid burden marker of AD brains.
Article
Biochemistry & Molecular Biology
Illhwan Cho, Soljee Yoon, Sunghyun Park, Seung Woo Hong, Eunjung Cho, Eosu Kim, Hye Yun Kim, YoungSoo Kim
Summary: This article introduces a method for identifying A beta peptide, which is gradually becoming a biomarker for Alzheimer's disease, and for targeting compounds used in diagnostics and drug development. By immobilizing fragmented A beta hexamers on a microplate and aggregating them with fluorescent full-length A beta, a mapping approach is reported for exploring targeting residues of A beta-imaging probes and A beta-regulating drug candidates. Through experimental validation, the authors were able to gain mechanistic understanding of how these compounds target nonfibrillar A beta.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Mungyo Jung, Songmin Lee, Sohui Park, Jihye Hong, Cheesue Kim, Illhwan Cho, Hee Su Sohn, Kyunghwan Kim, In Wook Park, Soljee Yoon, Sungpil Kwon, Jisu Shin, Donghee Lee, Mikyung Kang, Seokhyung Go, Sangjun Moon, Yeonseok Chung, YoungSoo Kim, Byung-Soo Kim
Summary: Alzheimer's disease, the most common cause of dementia, has multiple pathophysiological mechanisms. Current immunotherapy approaches targeting single mechanism have limitations. A nanovaccine has been developed to target multiple mechanisms and show higher efficacy in treating Alzheimer's disease in mice. The nanovaccine is easy-to-prepare and cost-effective, providing a novel treatment option for Alzheimer's disease.
ADVANCED MATERIALS
(2023)
Article
Biophysics
Michael J. Poellmann, Jiyoon Bu, Stanley Liu, Andrew Z. Wang, Steven N. Seyedin, Chandrikha Chandrasekharan, Heejoo Hong, YoungSoo Kim, Joseph M. Caster, Seungpyo Hong
Summary: A highly sensitive liquid biopsy using circulating tumor cells (CTCs) was used to monitor gastrointestinal cancer patients and predict disease recurrence. The approach captured CTCs from peripheral blood and employed a machine learning algorithm to quantify their abundance. The results showed that the CTC counts obtained 3 months post-treatment were predictive of disease progression.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Medicinal
Jinsheng Cui, Suhyun Ye, Daniel Shin, Illhwan Cho, Hye Yun Kim, Yun Kwon, Keunwan Park, Sang-Jip Nam, YoungSoo Kim, Dong-Chan Oh
Summary: Two new glycosylated and succinylated macrocyclic lactones, succinyl glyco-oxydifficidin (1) and succinyl macrolactin O (2), were isolated from a Bacillus strain collected from an intertidal mudflat on Anmyeon Island in Korea. Their planar structures were proposed using mass spectrometric analysis and NMR spectroscopic data, while the absolute configurations were determined through various methods. Biological evaluation showed that both compounds have potential therapeutic effects in inhibiting and dissociating amyloid beta (A beta) aggregation.
Article
Multidisciplinary Sciences
Illhwan Cho, HeeYang Lee, Donghee Lee, In Wook Park, Soljee Yoon, Hye Yun Kim, YoungSoo Kim
Summary: A beta(pE3-42) peptides were synthesized using microwave-assisted solid-phase peptide synthesis and their amyloidogenic and pathological functions were evaluated. The synthesized peptides showed amyloidogenic activity and cellular toxicity. In animal models, A beta(pE3-42) aggregates induced cognitive deficits and synaptic dysfunction.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Hee Yang Lee, Soljee Yoon, Jeong Hwa Lee, Keunwan Park, Youngeun Jung, Illhwan Cho, Donghee Lee, Jisu Shin, Kyeonghwan Kim, Sunmi Kim, Jimin Kim, Koeun Kim, Seung Hoon Han, Seong Muk Kim, Hye Ju Kim, Hye Yun Kim, Ikyon Kim, Young Soo Kim
Summary: The study identified YIAD002 as a potent dissociator of Aβ aggregates, showing significant reduction in amyloid burden, improved cognitive performance, and alleviated major pathological hallmarks of AD. Mechanism studies suggest that YIAD002 interferes with intermolecular beta-sheet fibrillation by directly interacting with specific domains of Aβ.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Songmin Lee, Anuradha Dagar, Illhwan Cho, Kyeonghwan Kim, In Wook Park, Soljee Yoon, Minhae Cha, Jisu Shin, Hye Yun Kim, Ikyon Kim, YoungSoo Kim
Summary: YIAD-0121 is a small molecule that can dissociate preformed amyloid-beta fibrils. In vitro experiments showed that YIAD-0121 can inhibit the aggregation of amyloid-beta. Treatment with YIAD-0121 in transgenic AD mice prevented the increase of cerebral amyloid-beta aggregation and slowed down the progression of hippocampus-dependent cognitive decline, along with reduced neuroinflammation.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Donghee Lee, Ji Eun Ryoo, Seungpyo Hong, Hye Yun Kim, YoungSoo Kim
Summary: Alzheimer's disease is characterized by accumulation of Aβ peptides in the brain, which lead to cognitive dysfunctions. Carprofen, a non-steroidal anti-inflammatory drug, accelerates the formation of Aβ plaques, but also alleviates the pathological features of AD, including neuroinflammation and impaired memory.
SCIENTIFIC REPORTS
(2023)
Review
Medicine, Research & Experimental
Hyomin Jeong, Heewon Shin, Seungpyo Hong, YoungSoo Kim
Summary: Alzheimer's disease (AD) has been mainly focused on clearing A beta plaques or preventing amyloidogenesis. However, recent evidence has shown that A beta has biological functions, such as suppressing microbial infections and regulating synaptic plasticity. Therefore, novel therapeutics targeting A beta should selectively target neurotoxic forms while preserving the physiological functions of A beta monomers.
EXPERIMENTAL NEUROBIOLOGY
(2022)