Review
Pharmacology & Pharmacy
Costas Thomopoulos, John Ntalakouras, Dimitris Polyzos, Dimitris Konstantinidis, Lina Palaiodimou, Georgios Tsivgoulis, Costas Tsioufis
Summary: This study conducted a meta-analysis of randomized trials to compare the efficacy and safety of low-dose DOACs and warfarin in preventing ischemic stroke and systemic embolism in patients with non-valvular Atrial Fibrillation. The results showed that low-dose DOACs had a more favorable net clinical benefit profile compared to warfarin.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sutee Limcharoen, Manat Pongchaidecha, Piyarat Pimsi, Sarawuth Limprasert, Juthathip Suphanklang, Weerayuth Saelim, Wichai Santimaleeworagun, Pornwalai Boonmuang
Summary: Apixaban is effective in preventing stroke events in patients with NVAF, but the association between apixaban plasma levels and bleeding events in Asian populations is limited. This study found that bleeding events were associated with higher apixaban trough levels and bleeding history. Most patients had apixaban plasma levels within the expected range.
Article
Clinical Neurology
Soonil Kwon, So-Ryoung Lee, Eue-Keun Choi, Euijae Lee, Jin-Hyung Jung, Kyung-Do Han, Myung-Jin Cha, Seil Oh, Gregory Y. H. Lip
Summary: This study compared the effectiveness and safety of NOACs and warfarin among atrial fibrillation patients with prior GIB using the Korean claims database. The findings showed that NOACs were associated with lower risks of ischemic stroke and major bleeding compared to warfarin in this patient population.
Article
Medicine, General & Internal
Hsing-Jung Li, Shin-Yi Lin, Fang-Ju Lin, Chi-Sheng Hung, Chi-Chuan Wang
Summary: The study compared the effectiveness and safety outcomes of NOACs and warfarin in patients with AF and VHD, showing that NOACs reduce the risk of venous thromboembolism, intracranial hemorrhage, and mortality compared to warfarin.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Article
Medicine, General & Internal
Sola Han, Young-Hoon Kim, Myung-Yong Lee, Oh Young Bang, Sung-Won Jang, Seongwook Han, Yoo-Jung Park, Seongsik Kang, Young Keun On, Hae Sun Suh
Summary: In Asian patients with NVAF, reduced-dose NOACs were associated with a significantly lower risk of stroke/systemic embolism and major bleeding compared to warfarin.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Rungroj Krittayaphong, Thanita Boonyapiphat, Suchart Aroonsiriwattana, Pornchai Ngamjanyaporn, Gregory Y. H. Lip
Summary: This study aimed to determine the causes of death in Asian non-valvular atrial fibrillation (AF) patients registered in a nationwide AF registry, and investigate the differences in causes of death between AF patients who were taking and not taking oral anticoagulant (OAC). The COOL-AF study in Thailand enrolled 3,405 non-valvular AF patients and found that non-cardiovascular death, such as infection/sepsis or malignancy, was more prevalent than cardiovascular death in Asian AF patients. Thus, an improved integrated care approach is needed to reduce non-cardiovascular death in Asian AF patients.
Review
Multidisciplinary Sciences
Bailin Zhang, Winglam Cheng, Wulamiding Kaisaier, Zhenbang Gu, Wengen Zhu, Qiuhua Jiang
Summary: This meta-analysis found that edoxaban had lower risks of stroke or systemic embolism, major bleeding, and intracranial hemorrhage compared to other oral anticoagulants in patients with AF.
Article
Medicine, General & Internal
Alpesh Amin, Allison Keshishian, Dionne M. Hines, Oluwaseyi Dina, Hannah Le, Lisa Rosenblatt, Xianchen Liu, Qisu Zhang, Lien Vo
Summary: The study found that DOACs were associated with a lower risk of stroke/SE and major bleeding, as well as lower medical costs compared to warfarin. Apixaban and dabigatran had significantly lower risks of all three outcomes compared to warfarin.
CURRENT MEDICAL RESEARCH AND OPINION
(2022)
Review
Cardiac & Cardiovascular Systems
Fuwei Liu, Yupei Zhang, Jun Luo, Yue Zhou
Summary: This meta-analysis concluded that in patients with atrial fibrillation (AF), the use of non-vitamin K oral anticoagulants (NOACs) did not increase the risk of intraocular bleeding compared to warfarin. Sensitivity analysis even suggested that NOAC users had a lower incidence of intraocular bleeding. Further research is needed to confirm if NOACs are superior to warfarin.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Urology & Nephrology
Frida Welander, Henrik Renlund, Emoke Dimeny, Henrik Holmberg, Anders Sjalander
Summary: This study found that warfarin treatment is associated with a lower risk of ischemic stroke but a higher risk of major bleeding in patients with non-valvular atrial fibrillation and severely reduced glomerular filtration rate. The existing observational data are conflicting, highlighting the need for further randomized controlled trials.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Medicine, General & Internal
Seung Min Kim, Eun-Tae Jeon, Jin-Man Jung, Ji-Sung Lee
Summary: The study evaluated the comparative efficacy and safety of 4 non-vitamin K antagonist oral anticoagulants (NOACs) and warfarin in Asians with non-valvular atrial fibrillation. Edoxaban ranked best in terms of IS and ICH prevention in the total study population, while apixaban ranked best for SSE, major bleeding, and GI bleeding. Apixaban and edoxaban may be relatively better treatment options for Asian patients with non-valvular atrial fibrillation.
Article
Geriatrics & Gerontology
Kuo-Hsuan Chang, Chiung-Mei Chen, Chun-Li Wang, Hui-Tzu Tu, Yu-Tung Huang, Hsiu-Chuan Wu, Chien-Hung Chang, Shang-Hung Chang
Summary: This retrospective cohort study examined the association between direct oral anticoagulants (DOACs) and concurrent antidepressant use in patients with atrial fibrillation (AF). The study found that concurrent use of bupropion with DOACs increased the risk of major bleeding and gastrointestinal hemorrhage. The combinations of DOACs with selective serotonin reuptake inhibitors (SSRIs) and tetracyclic antidepressants (TeCAs) were associated with an increased risk of intracerebral hemorrhage. The study suggests that careful consideration should be given to drug-drug interactions when prescribing DOACs to adult patients with AF.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Myrthe M. A. Toorop, Qingui Chen, Vladimir Y. I. G. Tichelaar, Suzanne C. Cannegieter, Willem M. Lijfering
Summary: Persistence with direct oral anticoagulants (DOACs) in non-valvular atrial fibrillation (NVAF) patients is a concern, and non-persistence within 4 years was associated with poor efficacy of ischemic stroke prevention. Identified baseline characteristics may help identify patients at risk of non-persistence.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Gregory Y. H. Lip, Allison Keshishian, Amiee Kang, Xuemei Luo, Nipun Atreja, Yan Zhang, Patricia Schuler, Jenny Jiang, Huseyin Yuce, Steven Deitelzweig
Summary: In this real-world analysis of NVAF patients with prior bleeding, NOACs were found to have similar or lower risk of stroke/SE and MB compared to warfarin, and there was variable risk of stroke/SE and MB among each other.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Gastroenterology & Hepatology
Steven Deitelzweig, Allison Keshishian, Amiee Kang, Amol D. Dhamane, Xuemei Luo, Neeraja Balachander, Lisa Rosenblatt, Jack Mardekian, Jenny Jiang, Huseyin Yuce, Gregory Y. H. Lip
Summary: Patients with major GI bleeding on oral anticoagulant treatment have a higher risk of stroke/systemic embolism, major bleeding, and mortality after discharge, with a significant proportion discontinuing their medication. Effective management strategies are needed for these high-risk patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dong-Hyuk Cho, Yun Gi Kim, Jimi Choi, Hee-Dong Kim, Mi-Na Kim, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim, Wan-Joo Shim, Seong-Mi Park
Summary: Impaired atrial functional reserve during exercise may indicate early-stage atrial cardiomyopathy in patients with paroxysmal atrial fibrillation (PAF) and is associated with AF recurrence. Atrial cardiomyopathy can occur independently of changes in LV function and even in patients with normal-sized left atria.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Pharmacology & Pharmacy
Chanhyun Park, Ji-Haeng Heo, Sanica Mehta, Sola Han, Jennifer C. Spencer
Summary: This study aimed to estimate the impact of individual adjuvant endocrine therapy (AET) types on treatment efficacy and overall survival in breast cancer patients. The study found that the tamoxifen group had a faster decrease in adherence compared to anastrozole, letrozole, and exemestane, and higher adherence was associated with a lower risk of mortality.
CLINICAL DRUG INVESTIGATION
(2023)
Article
Medicine, General & Internal
Yun Gi Kim, Kyung-Do Han, Seung-Young Roh, Joo Hee Jeong, Yun Young Choi, Kyongjin Min, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: This study found that being underweight is significantly associated with an increased risk of sudden cardiac death in people with diabetes. Individuals with a BMI below 18.5 had a 2.4-fold increased risk of sudden cardiac death during the follow-up period. Comparatively, the underweight group had a higher risk of sudden cardiac death compared to the obese group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Gi Kim, Seung-Young Roh, Joo Hee Jeong, Hyoung Seok Lee, Kyongjin Min, Yun Young Choi, Kyung-Do Han, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: Long-term increase in fasting blood glucose (FBG) is associated with higher risk of sudden cardiac arrest (SCA) in individuals with diabetes mellitus (DM), while a long-term decrease in FBG is not associated with reduced SCA risk. Preventing increase in FBG can have significant impacts on public health in terms of SCA prevention.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Gi Kim, Joo Hee Jeong, Kyung-Do Han, Seung-Young Roh, Kyongjin Min, Hyoung Seok Lee, Yun Young Choi, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: This study investigated the association between LDL-cholesterol level and sudden cardiac arrest (SCA) risk in patients with diabetes mellitus. The results showed a U-shaped association, with both low and high LDL-cholesterol levels being associated with increased SCA risk in diabetes patients.
CARDIOVASCULAR DIABETOLOGY
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Chanhyun Park, Sola Han, Boon Peng Ng
Review
Health Care Sciences & Services
Yi-Shao Liu, Ryan Thaliffdeen, Sola Han, Chanhyun Park
Summary: The objective of this systematic review is to summarize the use of machine learning in predicting overall survival in patients with bladder cancer. The most common algorithms used in the included studies were artificial neural networks and logistic regression. The review highlights the promise of machine learning in optimizing bladder cancer care through accurate survival predictions, but also emphasizes the challenges related to data processing, feature selection, and data source quality.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Medicine, General & Internal
Yun Gi Kim, Joo Hee Jeong, Seung-Young Roh, Kyung-Do Han, Yun Young Choi, Kyongjin Min, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: Based on a nationwide health insurance database, this study investigated the impact of body weight status on the risk of sudden cardiac arrest (SCA). The study found that obesity, as measured by body-mass index (BMI) and waist circumference, was initially associated with increased risk of SCA, but this association disappeared after adjusting for other risk factors. The findings suggest that considering metabolic disorders, demographics, and social habits may provide better understanding and prevention of SCA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Qing He, Georgianne Tiu Hawkins, Chanhyun Park, Sola Han, Jacqueline B. LaManna, Boon Peng Ng
Summary: This study aimed to investigate patient attitudes, experiences, and satisfaction with healthcare associated with office visit utilization among Medicare beneficiaries with type 2 diabetes. Based on the analysis of the 2019 Medicare Current Beneficiary Survey Public Use File, it was found that a considerable proportion of beneficiaries reported low office visit utilization. Factors such as gender, ethnicity, marital status, and place of residence were associated with office visit frequency. Patient attitudes towards healthcare privacy and dissatisfaction with transportation convenience were barriers to higher office visit utilization.
Article
Cardiac & Cardiovascular Systems
Jeongduk Seo, Yae Min Park, Yong Hoon Shin, Albert Youngwoo Jang, Woong Chol Kang, Wook-Jin Chung, Young-Hoon Kim, In Suck Choi
Summary: Atrial fibrosis in the right atrium may be the mechanism behind atrial fibrillation and intra-atrial conduction delay. Scar homogenization in the right atrium can improve intra-atrial conduction delay.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yun Young Choi, Jong-Il Choi, Joo Hee Jeong, Hyoung Seok Lee, Yun Gi Kim, Mi-Na Kim, Seung-Young Roh, Jaemin Shim, Jin Seok Kim, Seong-Mi Park, Young-Hoon Kim
Summary: This study found that a higher pulmonary artery pressure (PAP) is associated with an increased risk of recurrence after radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation, suggesting a mechanism by which pulmonary vascular dysfunction may lead to pulmonary vein impairment and left atrial remodeling.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Mohammad Iqbal, Iwan Cahyo Santosa Putra, Rizki Bunawan, Hanna Goenawan, Mohammad Rizki Akbar, Arief Sjamsulaksan Kartasasmita, Young Hoon Kim
Summary: This study shows that early cardiac remodeling may occur within 1 month after pacemaker implantation, as indicated by an increase in soluble suppression of tumorigenicity 2 (sST2) level. The sST2 level was significantly higher 1 month after implantation compared to before. Early detection of cardiac remodeling is important to prevent pacing induced cardiomyopathy.
Article
Medicine, General & Internal
Seung-Young Roh, Dae-In Lee, Kwang-No Lee, Jinhee Ahn, Yong-Soo Baek, Dong-Hyeok Kim, Jaemin Shim, Jong-Il Choi, Young-Hoon Kim
Summary: This study found that patients with atrial fibrillation (AF) have a higher left atrial pressure response (LAPR) to incremental pacing, which can predict left ventricular diastolic dysfunction. High E/e' values and body mass index were independent predictors of pacing-induced left atrial hypertension.
MEDICINA-LITHUANIA
(2023)
Article
Cardiac & Cardiovascular Systems
Hyo-Jeong Ahn, Myung-Jin Cha, Euijae Lee, So-Ryoung Lee, Eue-Keun Choi, Seongwook Han, Gi-Byung Nam, Jong-Il Choi, Hui-Nam Pak, Il-Young Oh, Dong-Gu Shin, Young Keun On, Sang Weon Park, Young-Hoon Kim, Seil Oh
Summary: This study investigated the recurrence of atrial fibrillation (AF) after radiofrequency catheter ablation (RFCA) in young patients. The results showed that patients under 60 years old had a higher rate of AF recurrence within 1 year after the procedure. These young patients may have distinct pathophysiology of AF and require more comprehensive management.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kyungseon Choi, Sang Jun Park, Sola Han, Yongseok Mun, Da Yun Lee, Dong-Jin Chang, Seok Kim, Sooyoung Yoo, Se Joon Woo, Kyu Hyung Park, Hae Sun Suh
Summary: This study evaluated the patient-centered economic burden of exudative AMD for two years, demonstrating a significant impact on reimbursement, nonreimbursement, and out-of-pocket costs. This highlights the need for expanded reimbursement strategies for patients with this condition.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)