Review
Immunology
Mingzhu Li, Chao Zhao, Yun Zhao, Jingran Li, Lihui Wei
Summary: The incidence rate and mortality rate of cervical cancer have been increasing among young women in China. To address this, it is crucial to improve HPV vaccination rates, especially among the younger population. China currently offers five types of HPV vaccines, all of which have undergone clinical trials and have been proven to be safe, effective, and immunogenic in preventing persistent HPV infections and genital precancerous lesions. However, the low vaccination rate in China calls for increased efforts to reduce the incidence and mortality rates of cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Kandace L. Amend, Bruce Turnbull, Li Zhou, Morgan A. Marks, Christine Velicer, Patricia Saddier, John D. Seeger
Summary: This study assesses the safety of the 4-valent HPV vaccine in males and finds associations with same-day allergic reactions, ear infections, intracranial injury, cellulitis, and concussion. However, other adverse outcomes are determined to be more likely related to activities common in adolescent males rather than the vaccination itself.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Infectious Diseases
Min-Taek Lee, Wonbin Choi, Seung-Hun You, Sewon Park, Jeong-Yeon Kim, Dal Ri Nam, Ju Won Lee, Sun-Young Jung
Summary: This study utilized latent class analysis to identify five clusters of serious adverse events (AEs) following mRNA COVID-19 vaccination, and examined the potential factors associated with each cluster. The findings highlight the importance of monitoring and understanding the safety profiles of mRNA COVID-19 vaccines.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Immunology
John Hansen, Arnold Yee, Ned Lewis, Se Li, Christine Velicer, Patricia Saddier, Nicola P. Klein
Summary: The study aimed to assess the safety of the nine-valent human papillomavirus vaccine (HPV9) following routine administration. The results showed that there were no new safety concerns identified related to HPV9.
Article
Medicine, General & Internal
Kalyani Sonawane, Yueh-Yun Lin, Haluk Damgacioglu, Yenan Zhu, Maria E. Fernandez, Jane R. Montealegre, Cecilia Ganduglia Cazaban, Ruosha Li, David R. Lairson, Ying Lin, Anna R. Giuliano, Ashish A. Deshmukh
Summary: By analyzing data from the National Immunization Survey and Vaccine Adverse Event Reporting System from 2015 to 2018, it was found that parents' safety concerns regarding the HPV vaccine have increased, while trends in adverse event reporting have not changed significantly. These findings suggest an urgent need to address caregivers' safety concerns in order to increase HPV vaccine confidence.
Article
Immunology
Lauri E. Markowitz, John T. Schiller
Summary: HPV vaccines are highly effective in preventing HPV-attributable cancers and have been introduced into national immunization programs in over 100 countries. The success of these vaccines has sparked interest in ambitious disease reduction goals.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Guohua Zhong, Chunlan Zhuang, Xiaowen Hu, Qi Chen, Zhaofeng Bi, Xinhua Jia, Siying Peng, Yufei Li, Yue Huang, Qiufen Zhang, Ying Hong, Youlin Qiao, Yingying Su, Huirong Pan, Ting Wu, Lihui Wei, Shoujie Huang, Jun Zhang, Ningshao Xia
Summary: A study conducted in China showed that Hepatitis E vaccination during or shortly before pregnancy is not associated with increased risks for both the pregnant women and pregnancy outcomes.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Biotechnology & Applied Microbiology
Maria E. Sundaram, Burney A. Kieke, Kayla E. Hanson, Edward A. Belongia, Eric S. Weintraub, Matthew F. Daley, Rulin C. Hechter, Nicola. P. Klein, Edwin. M. Lewis, Allison L. Naleway, Jennifer C. Nelson, James G. Donahue
Summary: This observational cohort study investigated the occurrence of three rare and serious adverse events following 9-valent human papillomavirus (9vHPV) vaccination compared to other vaccinations. The study found no statistically significant increase in risks associated with 9vHPV vaccination for these adverse events.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Health Care Sciences & Services
Fabian Eibensteiner, Valentin Ritschl, Faisal A. Nawaz, Sajjad S. Fazel, Christos Tsagkaris, Stefan Tino Kulnik, Rik Crutzen, Elisabeth Klager, Sabine Volkl-Kernstock, Eva Schaden, Maria Kletecka-Pulker, Harald Willschke, Atanas G. Atanasov
Summary: This study used Twitter polls to gauge the public's perception on the safety and acceptance of COVID-19 vaccines, finding that while there was uncertainty about vaccine safety, there was a high willingness to undergo vaccination among the study sample.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Immunology
Sol Seo Choi, BongKyoo Choi
Summary: This study examines the social inequality in HPV vaccination among teenagers in the United States and finds that it differs based on the source of vaccination information. Low socioeconomic status teenagers have higher discrepancies between parental reports and provider records. The proportion of HPV-unvaccinated teenagers is lowest at the highest socioeconomic status level in parental reports, but the opposite is true in provider records.
Article
Virology
Rongdong Huang, Ruihuan Gan, Dongjuan Zhang, Jianxiong Xiao
Summary: This study found that the 2vHPV vaccine was associated with significantly more systemic adverse events compared to other vaccines and placebo, but no significant differences were observed in serious adverse events. Further research is needed to gather more information on the safety of HPV vaccines.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Immunology
Nchang'wa Nhumba, Bruno Sunguya
Summary: Cervical cancer is a major health issue in Tanzania, and the HPV vaccine is an effective intervention. However, the uptake of the second dose of the vaccine is low, with factors such as age, attitude, and awareness influencing the uptake.
Article
Oncology
Alexandre Crosnier, Chadi Abbara, Morgane Cellier, Laurence Lagarce, Marina Babin, Delphine Bourneau-Martin, Marie Briet
Summary: This study found that the renal toxicity of anti-EGFR drugs is primarily related to renal failure in the context of digestive toxicity. Signals of disproportionate reporting were observed for afatinib and erlotinib with acute kidney injury, and for afatinib, cetuximab, and erlotinib with renal failure. Additionally, erlotinib was associated with haemolytic and uremic syndrome and thrombotic microangiopathy.
Article
Immunology
John D. Seeger, Kandace L. Amend, Bruce R. Turnbull, Li Zhou, Morgan A. Marks, Christine Velicer, Patricia Saddier
Summary: This study assessed the risk of new onset autoimmune conditions among males receiving the 4-valent human papillomavirus (HPV) vaccine (4vHPV), and the results showed that the incidence of autoimmune conditions among vaccinated males was similar to that among unvaccinated males.
Article
Medicine, General & Internal
Giulia Ciccarese, Astrid Herzum, Gaetano Serviddio, Corrado Occella, Aurora Parodi, Francesco Drago
Summary: HPV vaccines may have a therapeutic role in addition to standard treatments for anogenital warts and oral warts, especially for persistent lesions.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Rebecca E. Chandler
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2020)
Article
Public, Environmental & Occupational Health
Lovisa Sandberg, Henric Taavola, Yasunori Aoki, Rebecca Chandler, G. Niklas Noren
Article
Public, Environmental & Occupational Health
Eiko Iwasa, Yu Fujiyoshi, Yuki Kubota, Ryota Kimura, Rebecca E. Chandler, Henric Taavola, G. Niklas Noren, Rika Wakao
Article
Public, Environmental & Occupational Health
Sara Hult, Daniele Sartori, Tomas Bergvall, Sara Hedfors Vidlin, Birgitta Grundmark, Johan Ellenius, G. Niklas Noren
Correction
Public, Environmental & Occupational Health
Linda Harmark, Gerda Weits, Rietje Meijer, Federica Santoro, G. Niklas Noren, Florence van Hunsel
Letter
Immunology
Karsten Juhl Jorgensen, Margrete Auken, Louise Brinth, Rebecca Chandler, Peter C. Gotzsche, Tom Jefferson
Article
Public, Environmental & Occupational Health
Stefan Baral, Rebecca Chandler, Ruth Gil Prieto, Sunetra Gupta, Sharmistha Mishra, Martin Kulldorff
Summary: In response to COVID-19, Sweden implemented a mitigation strategy focused on risk-tailored approaches and minimizing disruptions to education and healthcare services. Compared to other countries, Sweden reported higher case counts and mortality rates, impacting the socioeconomic situation.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Mathematics
Jonas Nordqvist
Summary: This paper discusses wildly ramified power series defined over a field of positive characteristic, introducing a new invariant called the second residue fixed point index and providing a closed formula for it. The new invariant is closely related to the residue fixed point index and characterizes power series with large multiplicity having the smallest possible multiplicity at the origin under iteration.
JOURNAL OF NUMBER THEORY
(2021)
Article
Public, Environmental & Occupational Health
Rika Wakao, Ingrid M. Lonnstedt, Yasunori Aoki, Rebecca E. Chandler
Summary: This study aimed to explore the sensitivity of a global database of individual case safety reports (ICSRs) to known pharmacogenomic risk variants common in Japan. The results showed that pharmacogenomic differences in populations may contribute to differences in adverse drug reaction (ADR) reporting between countries in a global database of ICSRs. Regional analyses within a global database can inform on the effectiveness of local risk minimization measures and should be leveraged to catalyze the conversion of real-world usage into safer use of drugs in ethnically tailored ways.
Article
Computer Science, Artificial Intelligence
G. Niklas Noren, Eva-Lisa Meldau, Rebecca E. Chandler
Summary: The study describes and evaluates the vigiGroup algorithm, which can identify and describe groups of individual case reports with similar suspected adverse drug reactions, taking into account co-reported adverse event terms. Results show that vigiGroup performs well in terms of clustering stability and clinical coherence, with consensus clustering and statistical shrinkage leading to meaningful improvements in performance compared to the baseline mixture model.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Corine Ekhart, Florence van Hunsel, Eugene van Puijenbroek, Rebecca Chandler, Eva-Lisa Meldau, Henric Taavola, G. Niklas Noren
Summary: This study explored the adverse event reporting pattern of vortioxetine and compared it with selective serotonin reuptake inhibitors. The results showed that the adverse event pattern of vortioxetine is consistent with labeled adverse events and the safety profile of selective serotonin reuptake inhibitors. Additionally, some previously unknown adverse event signals were identified.
Editorial Material
Public, Environmental & Occupational Health
Rebecca E. Chandler
Article
Pharmacology & Pharmacy
Rani Lill Anjum, Rebecca E. Chandler, Elena Rocca
Summary: This article presents a new approach for assessing causality in pharmacovigilance, known as the Dx3 approach. It qualitatively evaluates three types of dispositions related to drugs, patient vulnerability, and patient-drug interaction. The article provides a checklist to guide the assessment process and emphasizes the goals of offering a qualitative way to assess causality and encouraging the collection of qualitative patient narratives.
PHARMACEUTICAL MEDICINE
(2022)
Article
Immunology
Steven B. Black, Rebecca E. Chandler, Kathryn M. Edwards, Miriam C. J. M. Sturkenboom
Summary: During the SARS-CoV-2 pandemic, questions about vaccine safety arose. This article reviews the various tools and capabilities used for monitoring vaccine safety, discusses their strengths and limitations, and highlights the challenges faced by middle and low income countries due to unequal vaccine safety pharmacovigilance capacity.