The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses

Peptidyl arginine deiminase autoimmunity and the development of ACPA in rheumatoid arthritis. The "hapten carrier" model

(2019) Isabelle Auger et al.   Arthritis & Rheumatology

The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis

(2018) Yi Tian Ting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Biology of T Regulatory Type 1 Cells and Their Therapeutic Application in Immune-Mediated Diseases

(2018) Maria Grazia Roncarolo et al.   IMMUNITY

Citrullination only infrequently impacts peptide binding to HLA class II MHC

(2017) John Sidney et al.   PLoS One

Aire Gets Company for Immune Tolerance

(2015) Ludger Klein   CELL

Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

(2014) Agata N. Burska et al.   MEDIATORS OF INFLAMMATION

Citrulline-Specific Th1 Cells Are Increased in Rheumatoid Arthritis and Their Frequency Is Influenced by Disease Duration and Therapy

(2014) Eddie A. James et al.   Arthritis & Rheumatology

Autoantibodies to Posttranslationally Modified Type II Collagen as Potential Biomarkers for Rheumatoid Arthritis

(2013) Rocky Strollo et al.   ARTHRITIS AND RHEUMATISM

Induction of bone loss in DBA/1J mice immunized with citrullinated autologous mouse type II collagen in the absence of adjuvant

(2013) Anand Dusad et al.   IMMUNOLOGIC RESEARCH

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

(2013) Stephen W. Scally et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HLA-DRB1 Genotypes and the Risk of Developing Anti Citrullinated Protein Antibody (ACPA) Positive Rheumatoid Arthritis

(2013) Nathalie Balandraud et al.   PLoS One

Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis

(2012) Geoffrey M. Thiele et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

(2012) Soumya Raychaudhuri et al.   NATURE GENETICS

T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles

(2012) Soi Law et al.   ARTHRITIS RESEARCH & THERAPY

Identification and functional characterization of T cells reactive to citrullinated vimentin in HLA-DRB1*0401-positive humanized mice and rheumatoid arthritis patients

(2011) Omri Snir et al.   ARTHRITIS AND RHEUMATISM

HLA-DR1001 presents “altered-self” peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets

(2010) Eddie A. James et al.   ARTHRITIS AND RHEUMATISM

Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

(2010) Bryan Knuckley et al.   BIOCHEMISTRY

An Autoantigen-Specific, Highly Restricted T Cell Repertoire Infiltrates the Arthritic Joints of Mice in an HLA-DR1 Humanized Mouse Model of Autoimmune Arthritis

(2010) Z. Qian et al.   JOURNAL OF IMMUNOLOGY

Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis

(2009) Alexei von Delwig et al.   ARTHRITIS AND RHEUMATISM

Rheumatoid arthritis

(2009) Lars Klareskog et al.   LANCET

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis

(2009) Masako Murai et al.   NATURE IMMUNOLOGY

Immunity to Citrullinated Proteins in Rheumatoid Arthritis

(2008) Lars Klareskog et al.   Annual Review of Immunology

The shared epitope hypothesis in rheumatoid arthritis: Evaluation of alternative classification criteria in a large UK Caucasian cohort

(2008) Ann W. Morgan et al.   ARTHRITIS AND RHEUMATISM

Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice

(2008) Jonathan A. Hill et al.   JOURNAL OF EXPERIMENTAL MEDICINE