Review
Psychiatry
Adriana Farcas, Charles Hindmarch, Felicia Iftene
Summary: This article reviews recent research findings on the contribution of the BDNF gene Val66Met polymorphisms to schizophrenia. The Met/Met genotype is associated with higher positive symptom scores, while increased BDNF levels under Risperidone treatment correlate with weight gain in Val/Val genotype carriers.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Lijun Chu, Xia Sun, Xiaoju Jia, Dazhi Li, Ping Gao, Yong Zhang, Jie Li
Summary: This study found that anxiety trait is associated with the BDNF polymorphism in panic disorder patients. The BDNF Met/Met genotype may decrease plasma BDNF levels and increase trait anxiety.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Cheng-Loong Liang, Han-Jung Chen, Yi-Che Lee, Cheng-Chun Wu, Chon-Haw Tsai, Po-Lin Chen, Wei-Lun Chang, Po-Yen Yeh, Cheng-Yu Wei, Ming-Jun Tsai, Yu Sun, Chih-Hao Lin, Jiunn-Tay Lee, Ta-Chang Lai, Li-Ming Lien, Mei-Chen Lin, Cheng-Li Lin, Hao-Kuang Wang, Chung Y. Hsu
Summary: This study examined the impact of smoking on functional outcomes in young stroke patients in Taiwan. The results indicated that smokers had a higher risk of unfavorable functional outcomes at 3 months after stroke.
FRONTIERS IN NEUROLOGY
(2021)
Article
Genetics & Heredity
Buse Yuksel, Murat Dogan, Olcay Boyacioglu, Mustafa Sahin, Seda Orenay-Boyacioglu
Summary: Tinnitus is the perception of sound in the absence of external stimuli. The genes BDNF and BDNF-AS may play a role in the auditory pathway and affect hearing performance. This study suggests that certain polymorphisms in the BDNF-AS gene (rs925946, rs1488830, rs1519480, and rs10767658) may have an impact on the auditory pathway and affect hearing performance.
Article
Multidisciplinary Sciences
Louise Martens, Luisa Herrmann, Lejla Colic, Meng Li, Anni Richter, Gusalija Behnisch, Oliver Stork, Constanze Seidenbecher, Bjoern H. Schott, Martin Walter
Summary: This study found that the Met allele of the Val66Met SNP of the BDNF gene is associated with lower Glx/NAA ratio in the pregenual anterior cingulate cortex (pgACC). Met carriers did not show decreased glutamate or glutamine levels, but instead exhibited increased NAA compared to Val homozygotes. This finding may help explain conflicting evidence regarding Val66Met as a risk factor for developing psychiatric illnesses.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
A. Yehya, Z. Altaany, O. Beni-Yonis
Summary: This study aimed to screen MTH-FR C677T (A1298C) and BDNF G196A (Val66Met) polymorphisms in Jordanian patients with diabetic peripheral neuropathy (DPN) and determine their relationships. The results showed that the MTHFR C>T-677 SNP and the BDNF G>A-196 SNP can serve as genetic risk markers for DPN.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Xiangyang Xie, Jessica Houtz, Guey-Ying Liao, Yuting Chen, Baoji Xu
Summary: This study elucidates the role of brain-derived neurotrophic factor (BDNF) in controlling dietary fat intake. Mice with impaired BDNF release showed overconsumption of high-fat diet (HFD) and developed severe obesity. The results indicate that BDNF release suppresses excess dietary fat intake.
Article
Biochemistry & Molecular Biology
Mohamed E. Elhadidy, Ayman Kilany, Ola Hosny Gebril, Neveen Hassan Nashaat, Hala M. Zeidan, Amal Elsaied, Adel F. Hashish, Ehab Ragaa Abdelraouf
Summary: This study investigated the presence of the brain-derived neurotrophic factor (BDNF) val66Met polymorphism in a group of children with specific learning disorder (LD) and its impact on their cognitive abilities. The results showed that children with LD who carried the Met allele had a higher frequency of deficits in reading, writing, and phonemic segmentation compared to non-Met allele carriers. This suggests that the Val66Met polymorphism acts as a genetic modifier of learning performance in some children with specific learning disorder (developmental dyslexia).
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Review
Psychiatry
Yuxia Wang, Ou Li, Nana Li, Zhongwei Sha, Zhenghao Zhao, Jian Xu
Summary: This meta-analysis reviewed recent studies on the association between the BDNF Val66Met polymorphism and susceptibility to MDD. The findings showed that there is no significant association between the BDNF Val66Met polymorphism and MDD overall, but the Met allele is associated with genetic susceptibility to MDD among white populations.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychiatry
Shufang Mei, Wencai Chen, Sijing Chen, Yani Hu, Xiaoyan Dai, Xiujun Liu
Summary: This study found no association between the Val66Met polymorphism of the BDNF gene and susceptibility to ADHD through a meta-analysis.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Ding Quan Ng, Ivy Cheng, Claire Wang, Chia Jie Tan, Yi Long Toh, Yong Qin Koh, Yu Ke, Koon Mian Foo, Raymond J. Chan, Han Kiat Ho, Lita Chew, Mohamad Farid bin Harunal Rashid, Alexandre Chan
Summary: This study found that lower plasma BDNF levels were associated with worse cognitive function in cancer patients. BDNF may serve as a predictive biomarker for cancer-related cognitive impairment.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Vasiliki Koute, Amalia Michalopoulou, Vasileios Siokas, Athina-Maria Aloizou, Dimitrios Rikos, Dimitrios P. Bogdanos, Eleftherios Kontopoulos, Ioanna N. Grivea, George A. Syrogiannopoulos, Alexandros Papadimitriou, Georgios M. Hadjigeorgiou, Efthimios Dardiotis
Summary: The study revealed a significant association of the BDNF rs6265 variant with decreased headache risk, particularly in the dominant and log-additive models. Additionally, Val66Met was also linked to decreased childhood migraine risk for the first time.
NEUROLOGICAL RESEARCH
(2021)
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Mattia Fonderico, Giovanni Bosco Zimatore, Nunzia Alessandra Losignore, Sandro Sorbi, Maria Pia Amato
Summary: The study suggests a potential protective effect of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly due to the detrimental effect of increased BDNF concentration in a neuroinflammatory environment. Higher EDSS score is associated with a progressive disease course, with a marginal association with the presence of the BDNF Val66Met polymorphism.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Maria Yoldi-Negrete, Lino Palacios-Cruz, Elsa Tirado-Duran, Laura Ivonne Jimenez-Rodriguez, Joanna Jimenez-Pavon, Sandra Hernandez, Alejandro Aguilar, Ingrid Pamela Morales-Cedillo, Mariana Jimenez-Tirado, Ana Fresan-Orellana, Francisco Juarez Garcia, Claudia Becerra-Palars, Beatriz Camarena-Medellin
Summary: This study aims to identify demographic, clinical, cognitive, and genetic factors associated with poor functioning in patients with type I bipolar disorder (BD). The results showed that residual depressive symptoms, anxiety, cognitive complaints, and being a Met carrier were more frequent in the poor functioning group. Being a Met carrier and cognitive complaints were the most important predictors of poor functioning in type I BD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Brian S. Wolff, Hannah R. Allen, Li Rebekah Feng, Leorey N. Saligan
Summary: Recent clinical studies have suggested that a common polymorphism of the BDNF gene may be related to the severity of fatigue following cancer treatment. In this study, transgenic mice homozygous for the Val66Met BDNF gene were used to investigate the effect of the polymorphism on fatigue-like behavior. The results showed that the Val66Met mice lost more weight during the baseline wheel-running period and exhibited a less severe fatigue-like phenotype during the first week after chemotherapy treatment.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Robynne G. Braun, George F. Wittenberg
Summary: There are various technological and methodological approaches available for motor function rehabilitation after stroke, and it is important to tailor these approaches to specific patient impairments while avoiding unsubstantiated claims. Evidence suggests that neurorehabilitation methods can change measurable nervous system properties, but there are still gaps in understanding the neural substrates targeted, hindering their prescriptive application and general refinement. Ongoing research using technologies to capture quantitative information about motor performance is narrowing these gaps and improving efforts towards better functional recovery after stroke.
SEMINARS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Robynne G. Braun, Laura Heitsch, John W. Cole, Arne G. Lindgren, Adam de Havenon, Jason A. Dude, Keith R. Lohse, Steven C. Cramer, Bradford B. Worrall
Summary: This article discusses the limitations of global outcome measures in stroke clinical trials and highlights the importance of focusing on specific domains in the recovery process. It emphasizes the need to capture domain-specific aspects of recovery and suggests utilizing commonly collected clinical data to guide the selection of relevant recovery domains for more detailed testing.
Letter
Clinical Neurology
Adam de Havenon, Aaron Bangad, Lesli E. Skolarus, Chad M. Aldridge, Robynne G. Braun, John W. Cole, Steven C. Cramer, Arne G. Lindgren, N. Abimbola Sunmonu, Bradford B. Worrall, Keith R. Lohse