Heterogeneous expression of CFTR in insulin-secreting β-cells of the normal human islet

Variability in estimated gene expression among commonly used RNA-seq pipelines

(2020) Sonali Arora et al.   Scientific Reports

Chloride transporters and channels in β-cell physiology: revisiting a 40-year-old model

(2019) Mauricio Di Fulvio et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

In situ analysis reveals that CFTR is expressed in only a small minority of β-cells in normal adult human pancreas

(2019) Michael G White et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

New Understanding of β-Cell Heterogeneity and In Situ Islet Function

(2018) Richard K.P. Benninger et al.   DIABETES

Animal and model systems for studying cystic fibrosis

(2018) Bradley H. Rosen et al.   Journal of Cystic Fibrosis

The role of beta cell heterogeneity in islet function and insulin release

(2018) Daniela Nasteska et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men

(2018) Patrik Rorsman et al.   PHYSIOLOGICAL REVIEWS

LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion

(2018) Till Stuhlmann et al.   Nature Communications

Calcium Channels in Postnatal Development of Rat Pancreatic Beta Cells and Their Role in Insulin Secretion

(2018) Neivys García-Delgado et al.   Frontiers in Endocrinology

Electrophysiological properties of human beta-cell lines EndoC-βH1 and -βH2 conform with human beta-cells

(2018) Benoît Hastoy et al.   Scientific Reports

CFTR Influences Beta Cell Function and Insulin Secretion Through Non-Cell Autonomous Exocrine-Derived Factors

(2017) Xingshen Sun et al.   ENDOCRINOLOGY

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells

(2017) Anna Edlund et al.   Scientific Reports

Abnormal CFTR Affects Glucagon Production by Islet α Cells in Cystic Fibrosis and Polycystic Ovarian Syndrome

(2017) Wen Qing Huang et al.   Frontiers in Physiology

Heterogeneity of the Pancreatic Beta Cell

(2017) Giselle Dominguez Gutierrez et al.   Frontiers in Genetics

The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion

(2017) Shams Kursan et al.   Scientific Reports

Structural abnormalities in islets from very young children with cystic fibrosis may contribute to cystic fibrosis-related diabetes

(2017) Marika Bogdani et al.   Scientific Reports

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

(2016) Natalie R. Johnston et al.   Cell Metabolism

Role of CFTR in epithelial physiology

(2016) Vinciane Saint-Criq et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human islets contain four distinct subtypes of β cells

(2016) Craig Dorrell et al.   Nature Communications

Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets

(2015) David M. Blodgett et al.   DIABETES

Insulin secretion abnormalities in exocrine pancreatic sufficient cystic fibrosis patients

(2015) Jamie L. Wooldridge et al.   Journal of Cystic Fibrosis

IncreasedSlc12a1expression in β-cells and improved glucose disposal inSlc12a2heterozygous mice

(2015) Saeed Alshahrani et al.   JOURNAL OF ENDOCRINOLOGY

CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells

(2014) Anna Edlund et al.   BMC Medicine

Revisiting CFTR inhibition: a comparative study of CFTRinh-172 and GlyH-101 inhibitors

(2014) N Melis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Evidence for a Causal Relationship Between Early Exocrine Pancreatic Disease and Cystic Fibrosis–Related Diabetes: A Mendelian Randomization Study

(2014) David Soave et al.   DIABETES

Control of Insulin Secretion by Cytochromecand Calcium Signaling in Islets with Impaired Metabolism

(2014) Austin M. Rountree et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium

(2014)   NATURE BIOTECHNOLOGY

Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR

(2014) Jing Hui Guo et al.   Nature Communications

Update on cystic fibrosis-related diabetes

(2013) Andrea Kelly et al.   Journal of Cystic Fibrosis

Mitochondrial function and insulin secretion

(2013) Pierre Maechler   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Metabolic syndrome induces changes in KATP-channels and calcium currents in pancreatic β-cells

(2012) Myrian Velasco et al.   Islets

Cystic Fibrosis Transmembrane Regulator Inhibitors CFTRinh-172 and GlyH-101 Target Mitochondrial Functions, Independently of Chloride Channel Inhibition

(2010) M. Kelly et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Electrical activity in pancreatic islet cells: The VRAC hypothesis

(2010) Leonard Best et al.   Islets

A highly energetic process couples calcium influx through L-type calcium channels to insulin secretion in pancreatic β-cells

(2009) Seung-Ryoung Jung et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cystic Fibrosis-Related Diabetes: Current Trends in Prevalence, Incidence, and Mortality

(2009) A. Moran et al.   DIABETES CARE

On the measurement of the functional properties of the CFTR

(2008) Oscar Moran et al.   Journal of Cystic Fibrosis