Article
Multidisciplinary Sciences
Ivana Kern, Olaf Schoffer, Thomas Richter, Wieland Kiess, Gunter Flemming, Ulf Winkler, Juergen Quietzsch, Olaf Wenzel, Marlen Zurek, Ulf Manuwald, Janice Hegewald, Shi Li, Jens Weidner, Jan de Laffolie, Klaus-Peter Zimmer, Joachim Kugler, Martin W. Laass, Ulrike Rothe
Summary: This study investigated the incidence, prevalence and future trends of inflammatory bowel disease (IBD) in children and adolescents in Saxony, Germany. The results showed that the incidence and prevalence of IBD have been increasing over time, indicating the need for adequate healthcare resources for these young patients in the future.
Article
Multidisciplinary Sciences
Fan Dong, Ivana Kern, Jens Weidner, Kathleen Kuegler, Ulrike Rothe, Makan Amin, Martin W. Laass, Gunter Flemming, Ulf Winkler, Thomas Richter, Joachim Kugler, Ulf Manuwald
Summary: In Saxony, the incidence of Crohn's disease (CD) in children and adolescents has significantly increased from 2000 to 2014. This study aims to describe the initial characteristics and clinical course of CD in this population and identify drug treatment options associated with better outcomes.
Article
Gastroenterology & Hepatology
Joyce Wing Yan Mak, Carmen Lok Tung Ho, Kylie Wong, Tsz Yan Cheng, Terry Cheuk Fung Yip, Wai Keung Leung, Michael Li, Fu Hang Lo, Ka Man Ng, Shun Fung Sze, Chi Man Leung, Steven Woon Choy Tsang, Edwin Hok Shing Shan, Kam Hon Chan, Belsy C. Y. Lam, Aric Josun Hui, Wai Hung Chow, Siew Chien Ng
Summary: Elderly-onset IBD patients exhibit different clinical characteristics and disease course compared to adult-onset IBD patients, with a higher risk of infections and cancer development. These patients also have increased hospitalizations related to infections and IBD, highlighting the need for specific therapeutic strategies for this special population.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Multidisciplinary Sciences
Ulf Manuwald, Olaf Schoffer, Joachim Kugler, Henna Riemenschneider, Thomas Michael Kapellen, Wieland Kiess, Ulrike Rothe
Summary: The study investigated the trends of type 1 diabetes among children and adolescents in Saxony over the past 21 years, showing an increasing incidence rate but a stable point prevalence in recent years. Cohort prevalence is predicted to continue rising, suggesting the need for further research on environmental factors.
Article
Public, Environmental & Occupational Health
Shi Li, Ivana Kern, Ulf Manuwald, Joachim Kugler, Ulrike Rothe
Summary: This study aimed to assess the completeness of the Saxon Pediatric IBD Registry in Germany and provide an analysis of the data. The results showed a high level of completeness (95.7%) for the registry, indicating that the epidemiological data are reliable.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Article
Gastroenterology & Hepatology
Giulia Catassi, Giulia D'Arcangelo, Lorenzo Norsa, Matteo Bramuzzo, Iva Hojsak, Kaija-Leena Kolho, Claudio Romano, Marco Gasparetto, Angelo Di Giorgio, Seamus Hussey, Anat Yerushalmy-Feler, Dan Turner, Manar Matar, Batia Weiss, Anna Karoliny, Patrizia Alvisi, Christos Tzivinikos, Marina Aloi
Summary: This study compared the characteristics and disease course of very early-onset primary sclerosing cholangitis associated with inflammatory bowel disease (VEO-PSC-IBD) with early and adolescent-onset PSC-IBD. The results showed that VEO-PSC-IBD had similar baseline characteristics and a milder disease course compared to early-onset PSC-IBD.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Natalia S. F. Queiroz, Camilla de Almeida Martins, Abel B. Quaresma, Adriano A. F. Hino, Flavio Steinwurz, Ryan C. Ungaro, Paulo G. Kotze
Summary: In Latin America, IBD patients diagnosed with COVID-19 have similar outcomes to global data, with risk factors for severe COVID-19 being similar to previous reports.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Manasi Agrawal, Erica J. Brenner, Xian Zhang, Jean-Frederic Colombel, Michael D. Kappelman, Ryan C. Ungaro, Richard B. Gearry, Gilaad G. Kalpan, Michele Kissous-Hunt, James D. Lewis, Siew C. Ng, Jean-Francois Rahier, Walter Reinisch, Frank M. Ruemmele, Flavio Steinwurz, Fox E. Underwood
Summary: More than one third of IBD patients stopped medication due to COVID-19, with those diagnosed with ulcerative colitis or IBD-unspecified less likely to stop compared to Crohn's disease patients. Specific medications such as 5-aminosalicylic acid were more likely to be continued, while anti-tumour necrosis factor therapy and immunomodulator therapy were more likely to be stopped. Other demographic and clinical characteristics did not impact prescription patterns.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Mathematics, Interdisciplinary Applications
Vedrana Makevic, Ivan D. Milovanovich, Nevena Popovac, Radmila Jankovic, Jelena Trajkovic, Andrija Vukovic, Bojana Milosevic, Jovan Jevtic, Silvio R. de Luka, Andjelija Z. Ilic
Summary: This study aimed to differentiate between the two clinical phenotypes of inflammatory bowel disease (IBD) in pediatric patients, or either of the phenotypes versus control, using the fractal dimension and lacunarity of intestinal cell chromatin. The results showed significant differences in fractal dimension and lacunarity between the ulcerative colits (UC) group and Crohn's disease (CD) group, as well as the UC group and control group in most colon segments. The fractal dimension was also able to differentiate CD from the control group in the ileocecal valve and rectum. This study identified the potential of fractal analysis of intestinal cell nuclei as an observer-independent histological tool for diagnosing ulcerative colitis, paving the way for the development of computer-aided diagnosis systems.
FRACTAL AND FRACTIONAL
(2023)
Review
Gastroenterology & Hepatology
M. Ellen Kuenzig, Stephen G. Fung, Luba Marderfeld, Joyce W. Y. Mak, Gilaad G. Kaplan, Siew C. Ng, David C. Wilson, Fiona Cameron, Paul Henderson, Paulo G. Kotze, Jasmine Bhatti, Vixey Fang, Samantha Gerber, Evelyne Guay, Supun Kotteduwa Jayawarden, Leo Kadota, Fernando D. Maldonado, Jessica Amankwah Osei, Ryan Sandarage, Amanda Stanton, Melissa Wan, Eric Benchimol
Summary: The incidence of pediatric-onset inflammatory bowel disease (IBD) is increasing worldwide, with the highest rates in Northern Europe and North America and the lowest rates in Southern Europe, Asia, and the Middle East. Most studies reported significant increases in incidence, while there is limited data on very early onset IBD.
Article
Endocrinology & Metabolism
Zemin Lv, Yunyun Yu, Yangmei Luo, Song Lin, Xuang Xiang, Xiaowen Mao, Shigang Cheng
Summary: This study investigated the clinicopathological characteristics and long-term survival outcomes of pediatric adrenal malignancies. The results showed that there were no significant changes in the clinicopathological characteristics of pediatric adrenal malignancies in the past two decades, but the prognosis of patients has improved. Early diagnosis of the disease and complete resection of local tumors are key factors in improving prognosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pediatrics
Laurence Chapuy, Bertrand Leduc, David Godin, Amelie Damphousse, Nathalie Patey, Dorothee Dal Soglio, Prevost Jantchou, Colette Deslandres
Summary: This study reports the phenotype and outcomes of very-early-onset inflammatory bowel disease (VEO-IBD) and early-onset IBD (EO-IBD) in a Montreal pediatric cohort. The results showed differences in phenotype between VEO-IBD and EO-IBD, but there was no significant difference in the rate of steroid-free clinical remission between the two groups at 1-year post-diagnosis and at the end of follow-up.
FRONTIERS IN PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Patrizia Alvisi, Flavio Labriola, Luca Scarallo, Paolo Gandullia, Daniela Knafelz, Matteo Bramuzzo, Giovanna Zuin, Maria Rosa Pastore, Maria Teresa Illiceto, Erasmo Miele, Francesco Graziano, Claudio Romano, Daniela Bartoletti, Salvatore Oliva, Serena Arrigo, Fiammetta Bracci, Sara Renzo, Anna Agrusti, Marina Aloi, Paolo Lionetti
Summary: This study aimed to evaluate the epidemiological trends of pediatric inflammatory bowel diseases (IBD) in Italy from 2009 to 2018. The results showed that the minimal incidence rate of IBD in Italy seemed to have stabilized over the last two decades, with a slight predominance of ulcerative colitis (UC) over Crohn's disease (CD). The diagnostic delay for CD has significantly decreased, indicating an improved diagnostic capacity.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Pediatrics
Kaija-Leena Kolho
Summary: The prevalence of pediatric-onset inflammatory bowel disease (IBD) has been increasing in recent decades, leading to a rise in patients with moderate to severe disease subtype treated with TNF alpha antagonists. While most pediatric patients initially respond to these drugs, dose escalation may be required during the first year of therapy. Due to limited data on therapeutic drug monitoring during therapy with the TNF alpha-blocker adalimumab in pediatric patients, this review focuses on the literature on therapeutic drug monitoring of infliximab and its potential to guide management.
FRONTIERS IN PEDIATRICS
(2021)
Review
Health Care Sciences & Services
Jochen Schmitt, Martin Roessler, Peter Scriba, Felix Walther, Xina Grahlert, Maria Eberlein-Gonska, Ralf Kuhlen, Olaf Schoffer
Summary: This study did not provide evidence for reductions in mortality in patients ventilated for more than 24 hours due to clinical peer review. A stronger focus on identification of structures and care processes related to mortality is required to improve the effectiveness of clinical peer review.
BMJ QUALITY & SAFETY
(2023)
Article
Public, Environmental & Occupational Health
Luana F. Tanaka, Olaf Schoffer, Jochem Koenig, Veronika Weyer-Elberich, Maria Blettner, Stefanie J. Klug
Summary: This study analyzed baseline data from the MARZY study conducted in Germany from 2005 to 2007 to assess the prevalence of hysterectomy in women aged 30-65 years. The results showed that the prevalence of hysterectomy increased with age, with the highest rate occurring among women aged 60-64 years. The age at which hysterectomy occurred also showed a trend of being postponed. The majority of hysterectomies were performed due to benign diseases.
Article
Immunology
Dirk Roggenbuck, Alexander Goihl, Mandy Sowa, Steffi Lopens, Stefan Roediger, Peter Schierack, Karsten Conrad, Ulrich Sommer, Korinna Joehrens, Robert Gruetzmann, Dirk Reinhold, Martin W. Laass
Summary: This study examined the expression of GP2-isoform (GP21-4) in intestinal biopsies of pediatric patients with Crohn's disease (CD), coeliac disease (CeD), ulcerative colitis (UC), and healthy children (HC). The results showed that transcription of GP21-4 was elevated in the proximal small intestine in CeD and CD patients, and CeD patients had higher levels of duodenal GP22/4-mRNA compared to HC/UC patients. Duodenal synthesis of small GP2 isoforms was demonstrated in epithelial cells and Brunner glands, with a more frequent apical location in CD/CeD patients. All four GP2 isoforms interacted with gliadin and phosphopeptidomannan. Gliadin digestion improved binding to GP2 isoforms. The findings suggest an autoimmune link between CeD/CD and GP2.
CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Sabine Sommerlatte, Celine Lugnier, Olaf Schoffer, Patrick Jahn, Anna-Lena Kraeft, Eleni Kourti, Patrick Michl, Anke Reinacher-Schick, Jochen Schmitt, Thomas Birkner, Jan Schildmann, Stephan Herpertz
Summary: This study provides quantitative data on the mental burden and moral distress among physicians and nurses working in oncology in Germany, and found a significant correlation between mental burden and moral distress. To protect healthcare workers, it is necessary to provide a safe working environment and psychosocial support.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medical Informatics
Ines Reinecke, Joscha Siebel, Saskia Fuhrmann, Andreas Fischer, Martin Sedlmayr, Jens Weidner, Franziska Bathelt
Summary: This study presents an approach to increase the structuredness of drug data, based on available drug prescriptions and a drug catalog. Through the application of three algorithms, the degree of structuredness was significantly improved. The results show promising potential for further enhancing the accuracy of similarity matching algorithms.
JMIR MEDICAL INFORMATICS
(2023)
Review
Health Care Sciences & Services
Linda Ossenbrink, Tina Haase, Patrick Timpel, Olaf Schoffer, Madlen Scheibe, Jochen Schmitt, Stefanie Deckert, Lorenz Harst
Summary: This systematic review evaluated the effectiveness of digital health interventions containing game components on behavioral, patient-reported, and clinical outcomes for patients with type 2 diabetes. The findings suggest that these interventions can significantly improve motivation for physical activity, exercise intensity, dietary behavior, health literacy, mental quality of life, glycated hemoglobin level, BMI, fasting plasma glucose level, waist circumference, and aerobic capacity.
JMIR SERIOUS GAMES
(2023)
Article
Public, Environmental & Occupational Health
Christoph Bobeth, Kees Kleihues-van Tol, Martin Roessler, Veronika Bierbaum, Michael Gerken, Christian Guenster, Patrik Droege, Thomas Ruhnke, Monika Klinkhammer-Schalke, Jochen Schmitt, Olaf Schoffer
Summary: The WiZen project investigates the effectiveness of certification in oncology by linking nationwide health insurance and cancer registry data. The linkage quality was validated using indirect identifiers and the project provides a promising method for future health care research.
Article
Public, Environmental & Occupational Health
Jochen Schmitt, Thomas Bierbaum, Max Geraedts, Holger Gothe, Martin Haerter, Falk Hoffmann, Peter Ihle, Ursula Kramer, Monika Klinkhammer-Schalke, Silke Kuske, Stefanie March, Jens-Peter Reese, Olaf Schoffer, Enno Swart, Horst Christian Vollmar, Felix Walther, Wolfgang Hoffmann
Review
Medicine, General & Internal
Anke Reinacher-Schick, Matthias Philip Ebert, Pompiliu Piso, Dietrich Hueppe, Jochen Schmitt, Jan Schildmann
Summary: This study analyzed the impact of the COVID-19 pandemic on cancer care in Germany, specifically focusing on colonoscopies, colorectal cancer diagnoses, surgeries, and mortality rates. The findings showed an increase in screening colonoscopies but a decrease in diagnostic and therapeutic colonoscopies performed in hospitals. The number of first colorectal cancer diagnoses and surgeries also decreased. While specific mortality data from Germany were lacking, international modeling data suggested that decreased screening rates during the pandemic may lead to increased mortality, which can be partially offset by intensified screening strategies in the post-pandemic period.
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Letter
Medicine, General & Internal
Thomas Datzmann, Jochen Schmitt, Olaf Schoffer
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Fan Dong, Ivana Kern, Jens Weidner, Kathleen Kuegler, Ulrike Rothe, Makan Amin, Martin W. Laass, Gunter Flemming, Ulf Winkler, Thomas Richter, Joachim Kugler, Ulf Manuwald
Summary: In Saxony, the incidence of Crohn's disease (CD) in children and adolescents has significantly increased from 2000 to 2014. This study aims to describe the initial characteristics and clinical course of CD in this population and identify drug treatment options associated with better outcomes.
Article
Endocrinology & Metabolism
Martin Eichler, Leopold Hentschel, Susanne Singer, Beate Hornemann, Stephan Richter, Christine Hofbauer, Peter Hohenberger, Bernd Kasper, Dimosthenis Andreou, Daniel Pink, Jens Jakob, Robert Gruetzmann, Stephen Fung, Eva Wardelmann, Karin Arndt, Kerstin Hermes-Moll, Olaf Schoffer, Marius Fried, Helena K. Jambor, Juergen Weitz, Klaus-Dieter Schaser, Martin Bornhaeuser, Jochen Schmitt, Markus K. Schuler
Summary: This study investigated the Health-Related Quality of Life (HRQoL) in adult sarcoma patients and survivors through a longitudinal study. The results showed that HRQoL of sarcoma patients was influenced by factors such as tumor location, treatment method, and lifestyle. Additionally, female gender, age between 55 and 65 years, lower socioeconomic status, and comorbidities were associated with lower HRQoL. The study also found that HRQoL improved partially over time and with increased physical activity among sarcoma patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Vinzenz Voelkel, Michael Gerken, Kees Kleihues-van Tol, Olaf Schoffer, Veronika Bierbaum, Christoph Bobeth, Martin Roessler, Christoph Reissfelder, Alois Fuerst, Stefan Benz, Bettina M. Rau, Pompiliu Piso, Marius Distler, Christian Guenster, Judith Hansinger, Jochen Schmitt, Monika Klinkhammer-Schalke
Summary: This study analyzes the impact of certification of designated cancer centers on the survival of colorectal cancer patients in Germany. The findings suggest that treatment at certified facilities is associated with better outcomes.
Article
Public, Environmental & Occupational Health
Thomas Datzmann, Olaf Schoffer, Jochen Schmitt, Heiko Boehme, Johannes Fritzmann, Marius Distler, Ulrike Ubbelohde, Esther Giehl-Brown, Tjark Henke, Mechthild Krause, Hanno Glimm, Martin Bornhaeuser, Juergen Weitz
Summary: Translational research in medicine is crucial for driving medical innovations faster and more effectively. Clinical registries and prospective cohort studies play a key role in providing comprehensive data and advancing cutting-edge oncological research.