期刊
DRUG DISCOVERY TODAY
卷 21, 期 9, 页码 1521-1531出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2016.06.001
关键词
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资金
- College of Engineering and Informatics, NUI Galway
- Health Research Board [HRA_POR/2011/84]
- Science Foundation Ireland
- European Regional Development Funds [13/RC/2073]
- Health Research Board (HRB) [HRA-POR-2011-84] Funding Source: Health Research Board (HRB)
In vitro tumour models utilise various cancer cells and an appropriate extracellular matrix equivalent to recapitulate the in vivo tumour microenvironment. Three-dimensional tissue surrogates (e.g., decellularised tissue grafts, decellularised monolayers, hydrogels, electrospun fibres and sponges) are increasingly used as alternatives to conventional two-dimensional monolayer cultures to model the tissue environment more faithfully for drug development and screening. Herein, we critically assess the advances and shortfalls of these three-dimensional systems as in vitro models of cancer.
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