Review
Nutrition & Dietetics
Hammad Ullah, Ayesha Khan, Kannan R. R. Rengasamy, Alessandro Di Minno, Roberto Sacchi, Maria Daglia
Summary: Depression is a prevalent and serious health issue globally, and current treatment options are limited. SAMe and probiotics have shown potential therapeutic roles in depression by regulating microbial imbalance and reducing inflammation.
Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Article
Cell Biology
Takafumi Ogawa, Koji Masumura, Yuki Kohara, Muneyoshi Kanai, Tomoyoshi Soga, Yoshikazu Ohya, T. Keith Blackwell, Masaki Mizunuma
Summary: Methionine restriction can extend lifespan and delay aging-associated pathologies. Supplementation with S-adenosyl-L-homocysteine (SAH) can mimic the effects of methionine restriction by reducing methionine levels and activating AMP-activated protein kinase (AMPK), thereby extending lifespan.
Article
Biochemistry & Molecular Biology
Maria Becker, Karin Abaev, Elena Shmerkin, Liza Weinstein-Fudim, Albert Pinhasov, Asher Ornoy
Summary: This study found that SAMe treatment increased serotonin levels in the prefrontal cortex of female Sub mice and increased dopamine and DOPAC levels in both males and females. SAMe also changed the expression of genes related to monoamine metabolism. These effects may explain the alleviation of depressive symptoms and suggest the beneficial effects of SAMe as an epigenetic modulator in the treatment of depression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Sarah Holper, R. Watson, L. Churilov, P. Yates, Y. Y. Lim, K. J. Barnham, N. Yassi
Summary: This study aims to investigate whether daily oral administration of 400 mg S-adenosyl methionine (SAMe) can reduce plasma levels of p-tau181 in AD patients over 180 days, in order to attenuate or prevent AD-associated neurodegeneration. This is a randomized, double-blind, placebo-controlled trial involving 60 participants with mild cognitive impairment or dementia due to AD. The primary outcome measure is the change in plasma p-tau181 concentration between baseline and after 180 days of treatment.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2023)
Review
Pharmacology & Pharmacy
Jefferson A. Leite, Bruno Ghirotto, Vitor P. Targhetta, Jean de Lima, Niels O. S. Camara
Summary: Histone deacetylases (HDACs) play a crucial role in neurodegenerative and neuropsychiatric disorders, with both Zn2+-dependent and NAD(+)-dependent enzymes being potential therapeutic targets. While most studies have focused on Zn2+-dependent HDACs, growing evidence suggests that NAD(+)-dependent HDACs, known as sirtuins, also play an important role in pathogenesis.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Clinical Neurology
Raphael O. Cerqueira, Carolina Ziebold, Daniel Cavalcante, Giovany Oliveira, Javiera Vasquez, Juan Undurraga, Alfonso Gonzalez-Valderrama, Ruben Nachar, Carlos Lopez-Jaramillo, Cristiano Noto, Nicolas Crossley, Ary Gadelha
Summary: This study compares patients with affective and non-affective psychosis (A-FEP and NA-FEP) in a Latin American sample. The findings suggest that characteristics of FEP patients could be utilized to enhance diagnosis and inform treatment decisions.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Nutrition & Dietetics
Ting Liu, Kunhong Deng, Ying Xue, Rui Yang, Rong Yang, Zhicheng Gong, Mimi Tang
Summary: Depression is one of the most common mental diseases, but its understanding is insufficient. The relationship between carnitine and depression has been confirmed in multiple studies, and the level of acylcarnitines can serve as biomarkers for depression, while supplementing acetyl-L-carnitine is beneficial for the treatment of depression.
FRONTIERS IN NUTRITION
(2022)
Review
Genetics & Heredity
Kamila Czarnecka, Jakub Chuchmacz, Przemyslaw Wojtowicz, Pawel Szymanski
Summary: Memantine is a non-competitive N-methyl-D-aspartate receptor antagonist used to treat Alzheimer's disease by modulating glutamate transmission in the brain. Research suggests that it is well tolerated by patients and may also benefit conditions such as schizophrenia and depression.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Neurosciences
Md Asif Nashiry, Shauli Sarmin Sumi, Salem A. Alyami, Mohammad Ali Moni
Summary: Several studies have shown that many patients with Parkinson's disorder (PD) experience psychiatric symptoms such as depression, anxiety, hallucination, delusion, and cognitive dysfunction. To understand the relationship between PD and psychiatric symptoms, a bioinformatics framework was created to analyze the effects of PD mRNA expression on psychiatric disorders in PD patients. Through various analyses, significant correlations between PD and bipolar disorder and schizophrenia were found, providing crucial information for understanding the intricate relationship between PD and psychiatric diseases.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Yongzhi Gao, Nathaniel Martin, Matthijs J. van Haren
Summary: NNMT is an enzyme that methylates nicotinamide to generate 1-methyl nicotinamide, playing roles in human health beyond metabolic functions and contributing to various diseases, including cancers. However, the development of cell-active inhibitors against NNMT still faces challenges and lacks progress.
DRUG DISCOVERY TODAY
(2021)
Article
Psychiatry
Aidin Abbaspour, Masoud Bahreini, Sherafat Akaberian, Kamran Mirzaei
Summary: The study found that most patients with psychiatric disorders were affected by ineffective parenting styles. Despite the involvement of several bio-psycho-social factors in the development of psychiatric disorders, the crucial roles of parents, especially mothers, should not be ignored. It was suggested that parents and parental bonding were important and fundamental factors for mental health promotion.
Article
Psychiatry
Tuyen T. Le, Joshua D. Di Vincenzo, Kayla M. Teopiz, Yena Lee, Danielle S. Cha, Leanna M. W. Lui, Nelson B. Rodrigues, Roger C. Ho, Bing Cao, Kangguang Lin, Flora Nasri, Hartej Gill, Orly Lipsitz, Mehala Subramaniapillai, Rodrigo B. Mansur, Joshua D. Rosenblat, Roger S. McIntyre
Summary: Psychotic depression is a severe subtype of major depressive disorder with high relapse and mortality rates. Ketamine may be an alternative pharmacotherapy, but its efficacy and safety in patients with psychotic depression have not been established.
PSYCHIATRY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mangal S. Kadam, V. L. S. Prasad Burra
Summary: Methylation plays a significant role in various diseases, and methyltransferases are important targets for drug development. However, the function of methyltransferases relies on the presence of SAM. This article provides a comprehensive analysis of SAM-receptor interactions and reveals crucial insights into the structure and function of SAM.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Health Care Sciences & Services
Dror Ben-Zeev, Ayesha Chander, Justin Tauscher, Benjamin Buck, Subigya Nepal, Andrew Campbell, Guy Doron
Summary: This study conducted a fully remote randomized waitlist-controlled trial of CORE, a smartphone intervention for people with serious mental illness (SMI). Results showed that CORE was highly usable and acceptable, with significant reductions in psychiatric symptoms and disability levels, as well as improvements in recovery and self-esteem.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Medicine, Research & Experimental
Barbara Rejc, Yoji Kato, Natasa Karas-Kuzelicki, Josko Osredkar, Ksenija Gersak
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2016)
Article
Medicine, Research & Experimental
Natasa Karas-Kuzelicki, Simona Mencej-Bedrac, Janez Jazbec, Janja Marc, Irena Mlinaric-Rascan
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2016)
Article
Multidisciplinary Sciences
Alenka Smid, Natasa Karas-Kuzelicki, Janez Jazbec, Irena Mlinaric-Rascan
SCIENTIFIC REPORTS
(2016)
Article
Obstetrics & Gynecology
Barbara Rejc, Natasa Karas-Kuzelicki, Josko Osredkar, Ksenija Gersak
JOURNAL OF PERINATAL MEDICINE
(2017)
Review
Biochemistry & Molecular Biology
Raffaella Franca, Natasa K. Kuzelicki, Claudio Sorio, Eleonora Toffoletti, Oksana Montecchini, Alice Poropat, Marco Rabusin, Debora Curci, Dino Paladin, Gabriele Stocco, Giuliana Decorti
CURRENT MEDICINAL CHEMISTRY
(2018)
Article
Dentistry, Oral Surgery & Medicine
N. Karas Kuzelicki, A. Smid, T. Kek, A. Eberlinc, K. Gerak, I. Mlinaric-Rascan
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2018)
Article
Multidisciplinary Sciences
Alenka Smid, Natasa Karas-Kuzelicki, Miha Milek, Janez Jazbec, Irena Mlinaric-Rascan
Article
Pharmacology & Pharmacy
Natasa Karas Kuzelicki, Irena Prodan Zitnik, David Gurwitz, Adrian Llerena, Ingolf Cascorbi, Sofia Siest, Maurizio Simmaco, Marc Ansari, Mario Pazzagli, Chiara Di Resta, Ivan Brandslund, Matthias Schwab, Pieter Vermeersch, Jeantine E. Lunshof, George Dedoussis, Christodoulos S. Flordellis, Uwe Fuhr, Julia C. Stingl, Ron H. N. van Schaik, Vangelis G. Manolopoulos, Janja Marc
Article
Environmental Sciences
Masa Kenda, Natasa Karas Kuzelicki, Mitsuru Iida, Hiroyuki Kojima, Marija Sollner Dolenc
ENVIRONMENTAL HEALTH PERSPECTIVES
(2020)
Article
Pharmacology & Pharmacy
Masa Kenda, Damjan Avsec, Taja Zore, Eva Kogovsek, Ursa Pecar Fonovic, Janko Kos, Kristof Bozovicar, Tomaz Bratkovic, Natasa Karas Kuzelicki, Bojana Zegura, Metka Filipic, Marija Sollner Dolenc
Summary: This study investigated the effects of seven different TKIs on endocrine receptors, revealing varied activities such as antiestrogenic, antiandrogenic, and glucocorticoid activities. Synergistic effects were observed when certain TKIs were combined with glucocorticoids.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Lara Slavec, Natasa Karas Kuzelicki, Igor Locatelli, Ksenija Gersak
Summary: This study systematically reviewed the relevant genetic risk factors for non-syndromic orofacial cleft (nsOFC) in populations of European ancestry. The meta-analysis identified several genetic variants in genes/loci such as IRF6, GRHL3, 8q24, VAX1, TGFA, FOXE1, ABCA4, NOG, GREM1, AXIN2, DVL2, WNT3A, and WNT5A that are strongly associated with nsOFC phenotypes. These findings suggest that these genes have high potential as biomarkers for nsOFC in European populations.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Lara Slavec, Ksenija Gersak, Andreja Eberlinc, Tinka Hovnik, Luca Lovrecic, Irena Mlinaric-Rascan, Natasa Karas Kuzelicki
Summary: The etiology of nsOFC is usually multifactorial, while syOFC is often caused by single mutations in known genes. This study identified six disease-causing variants in three genes, showing the usefulness of their sequencing approach in distinguishing between syOFC and nsOFC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Natasa Karas Kuzelicki, Alenka Smid, Masa Vidmar Golja, Tina Kek, Borut Gersak, Uros Mazic, Irena Mlinaric-Rascan, Ksenija Gersak
Summary: This study investigated the association between polymorphisms in the genes of the folate and methionine pathways and the risk of congenital heart defects (CHDs). The rs2236225 polymorphism in the MTHFD1 gene was confirmed as an important modulator of CHD risk, while polymorphisms in the MTRR, FPGS, and SLC19A1 genes were identified as risk factors in only one of the models. Furthermore, a strong synergistic effect was found between the MTHFD1 polymorphism and a lack of maternal folate supplementation during early pregnancy.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
Review
Medicine, General & Internal
Jasna Omersel, Natasa Karas Kuzelicki
JOURNAL OF CLINICAL MEDICINE
(2020)