期刊
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
卷 42, 期 10, 页码 1621-1635出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/03639045.2016.1160106
关键词
Coating efficiency; contact angle; film formation; glass transition temperature; intrinsic viscosity; inverse gas chromatography; Myvacet (R) 9-45K; triethyl citrate
资金
- Harke Group
- BASF formerly Cognis
- Evonik Industries
- Henry Lamotte Oils
- Jungbunzlauer Ladenburg
- Kerry Ingredients Flavors
- Temmler Ireland
Solubility parameters of HPMCAS have not yet been investigated intensively. On this account, total and three-dimensional solubility parameters of HPMCAS were determined by using different experimental as well as computational methods. In addition, solubility properties of HPMCAS in a huge number of solvents were tested and a Teas plot for HPMCAS was created. The total solubility parameter of about 24 MPa0.5 was confirmed by various procedures and compared with values of plasticizers. Twenty common pharmaceutical plasticizers were evaluated in terms of their suitability for supporting film formation of HPMCAS under dry coating conditions. Therefore, glass transition temperatures of mixtures of polymer and plasticizers were inspected and film formation of potential ones was further investigated in dry coating of pellets. Contact angles of plasticizers on HPMCAS were determined in order to give a hint of achievable coating efficiencies in dry coating, but none was found to spread on HPMCAS. A few common substances, e.g. dimethyl phthalate, glycerol monocaprylate, and polyethylene glycol 400, enabled plasticization of HPMCAS; however, only triethyl citrate and triacetin were found to be suitable for use in dry coating. Addition of acetylated monoglycerides to triacetin increased coating efficiency, which was likewise previously demonstrated for triethyl citrate.
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