Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry

Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target

(2020) Haibo Zhang et al.   INTENSIVE CARE MEDICINE

Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report

(2020) Walter J. Chazin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration

(2020) Xu Yang et al.   Journal of the American Heart Association

Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532)

(2020) M. Montopoli et al.   ANNALS OF ONCOLOGY

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic

(2020)   EUROPEAN JOURNAL OF HUMAN GENETICS

The pivotal link between ACE2 deficiency and SARS-CoV-2 infection

(2020) Paolo Verdecchia et al.   European Journal of Internal Medicine

Baseline Characteristics and Outcomes of 1591 Patients Infected With SARS-CoV-2 Admitted to ICUs of the Lombardy Region, Italy

(2020) Giacomo Grasselli et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

(2020) Mushtaq Hussain et al.   JOURNAL OF MEDICAL VIROLOGY

Prevention and therapy of COVID-19 via exogenous estrogen treatment for both male and female patients

(2020) Zsuzsanna Suba   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

(2020) Markus Hoffmann et al.   MOLECULAR CELL

A preliminary observation: Male pattern hair loss among hospitalized COVID‐19 patients in Spain – A potential clue to the role of androgens in COVID‐19 severity

(2020) Andy Goren et al.   Journal of Cosmetic Dermatology

The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues

(2020) Behrooz Darbani   International Journal of Environmental Research and Public Health

Individual variation of the SARS‐CoV‐2 receptor ACE2 gene expression and regulation

(2020) Jiawei Chen et al.   AGING CELL

Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies

(2020) Georgia Ragia et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population

(2020) Elisa Benetti et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

COVID-19

(2020) Paolo Verdecchia et al.   HYPERTENSION

Genetic diversity and evolution of SARS-CoV-2

(2020) Tung Phan   INFECTION GENETICS AND EVOLUTION

ACE2 Expression Is Increased in the Lungs of Patients With Comorbidities Associated With Severe COVID-19

(2020) Bruna G G Pinto et al.   JOURNAL OF INFECTIOUS DISEASES

Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2

(2020) Stepan Nersisyan et al.   PLoS One

Polygenic risk scores in coronary artery disease

(2019) Abhiram S. Rao et al.   CURRENT OPINION IN CARDIOLOGY

Genetic Risk Scores for Diabetes Diagnosis and Precision Medicine

(2019) Miriam S Udler et al.   ENDOCRINE REVIEWS

Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium

(2018) Anja Rudolph et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

A rare loss-of-function variant of ADAM17 is associated with late-onset familial Alzheimer disease

(2018) Daniela Hartl et al.   MOLECULAR PSYCHIATRY

The personal and clinical utility of polygenic risk scores

(2018) Ali Torkamani et al.   NATURE REVIEWS GENETICS

MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells

(2018) Saya Ito et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Aberrant DNA methylation of ADAMTS16 in colorectal and other epithelial cancers

(2018) Felix Kordowski et al.   BMC CANCER

Histone demethylase KDM7A controls androgen receptor activity and tumor growth in prostate cancer

(2018) Kyoung-Hwa Lee et al.   INTERNATIONAL JOURNAL OF CANCER

Integrative epigenetic taxonomy of primary prostate cancer

(2018) Suzan Stelloo et al.   Nature Communications

Human Calmodulin Mutations

(2018) Helene H. Jensen et al.   Frontiers in Molecular Neuroscience

Protective regulation of the ACE2/ACE gene expression by estrogen in human atrial tissue from elderly men

(2017) A Bukowska et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

miRNAs as drivers of TMPRSS2-ERG negative prostate tumors in African American men

(2017) Moray J Campbell   Frontiers in Bioscience-Landmark

Preliminary analysis of the association between methylation of the ACE2 promoter and essential hypertension

(2017) Rui Fan et al.   Molecular Medicine Reports

The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells

(2017) Stephen Wilson et al.   Oncotarget

miRNA-200c-3p is crucial in acute respiratory distress syndrome

(2017) Qiang Liu et al.   Cell Discovery

TheACE2G8790A Polymorphism: Involvement in Type 2 Diabetes Mellitus Combined with Cerebral Stroke

(2016) Yan-Hui Wu et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Association between circulating levels of ACE2-Ang-(1–7)-MAS axis and ACE2 gene polymorphisms in hypertensive patients

(2016) Dan Liu et al.   MEDICINE

Tissue-Specific Expression of Estrogen Receptor 1 Is Regulated by DNA Methylation in a T-DMR

(2016) Ryo Maekawa et al.   MOLECULAR ENDOCRINOLOGY

Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: Role of epigenetic histone modifications

(2015) Kulbhushan Tikoo et al.   BIOCHEMICAL PHARMACOLOGY

Expression of ERG protein in prostate cancer: variability and biological correlates

(2015) G. Ayala et al.   ENDOCRINE-RELATED CANCER

Identification ofTMPRSS2as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza

(2015) Zhongshan Cheng et al.   JOURNAL OF INFECTIOUS DISEASES

The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans

(2015) et al.   SCIENCE

The ACE2/Apelin Signaling, MicroRNAs, and Hypertension

(2015) Lai-Jiang Chen et al.   International Journal of Hypertension

MicroRNA-145 Targets the Metalloprotease ADAM17 and Is Suppressed in Renal Cell Carcinoma Patients

(2015) Kai Doberstein et al.   NEOPLASIA

Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17

(2014) Jing Ren et al.   Cellular & Molecular Immunology

Analysis of ADAM17 Polymorphisms and Susceptibility to Sporadic Abdominal Aortic Aneurysm

(2014) You Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Novel Calmodulin Mutations Associated With Congenital Arrhythmia Susceptibility

(2014) N. Makita et al.   Circulation-Cardiovascular Genetics

Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells

(2014) Mingliang Chu et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MicroRNA-145 inhibits cell proliferation by directly targeting ADAM17 in hepatocellular carcinoma

(2014) YUWU LIU et al.   ONCOLOGY REPORTS

Androgen Regulation of the TMPRSS2 Gene and the Effect of a SNP in an Androgen Response Element

(2013) Liesbeth Clinckemalie et al.   MOLECULAR ENDOCRINOLOGY

TheACE2gene: its potential as a functional candidate for cardiovascular disease

(2012) Louise M. Burrell et al.   CLINICAL SCIENCE

ADAM-17: the enzyme that does it all

(2010) Monika Gooz   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Renin-angiotensin-aldosterone system gene polymorphisms in coronary artery bypass graft surgery patients

(2010) Georgia Ragia et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

A review of estrogen receptor α gene (ESR1) polymorphisms, mood, and cognition

(2010) Erin E. Sundermann et al.   MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY

Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

(2009) Hong Peng Jia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Identification of a Calmodulin-Binding Domain within the Cytoplasmic Tail of Angiotensin-Converting Enzyme-2

(2009) Zon W. Lai et al.   ENDOCRINOLOGY

Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection

(2009) Rui Xiang Lei et al.   HEPATOLOGY

Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2–ERG fusion status

(2009) K Mwamukonda et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Tissue-specific regulation of ACE/ACE2 and AT1/AT2receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-α knock-out mice

(2008) K. Bridget Brosnihan et al.   EXPERIMENTAL PHYSIOLOGY

Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study

(2008) P. E. Morange et al.   JOURNAL OF MOLECULAR MEDICINE-JMM