Review
Biochemistry & Molecular Biology
Lauren H. Fairley, Shatarupa Das, Vivek Dharwal, Nadia Amorim, Karl J. Hegarty, Ridhima Wadhwa, Guntipally Mounika, Philip M. Hansbro
Summary: Oxidative stress, primarily caused by reactive oxygen species (ROS) produced by impaired mitochondria, is a major feature of COPD. While antioxidants have shown potential in mitigating oxidative damage, currently available agents are not widely used. Mitochondria-targeted antioxidants (MTAs) offer a more precise approach to reducing ROS and have demonstrated greater protective effects in COPD, making them promising therapeutic agents. However, challenges and future directions for the use of MTAs in COPD treatment need to be discussed.
Review
Neurosciences
Priyajit Banerjee, Ishita Saha, Diptendu Sarkar, Arpan Kumar Maiti
Summary: Conventional therapeutics can only treat the symptoms of Parkinson's disease (PD), so the focus of research in recent years has been on slowing down or preventing the progression of neuronal degeneration in PD. Non-targeted antioxidants have been part of the conventional treatment, but their importance has diminished due to controversial results in clinical trials. In contrast, mitochondrial-targeted antioxidants (MTAs) have emerged as a better alternative with higher advantages, but sufficient clinical trials have not been conducted to investigate their efficacy in PD treatment.
NEUROTOXICITY RESEARCH
(2022)
Review
Cell Biology
Roman A. A. Zinovkin, Konstantin G. G. Lyamzaev, Boris V. V. Chernyak
Summary: Oxidative stress is always present in all stages of cancer development. Antioxidants can have both beneficial and detrimental effects, depending on the stage of cancer. Mitochondria-targeted antioxidants have potential in cancer therapy, but further research is needed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ekaterina M. Fock, Rimma G. Parnova
Summary: Lipopolysaccharide (LPS) challenge leads to oxidative stress and mitochondrial dysfunction, causing cell and tissue damage. Mitochondrial reactive oxygen species (mtROS) play a key role in inflammation, with excessive levels impairing mitochondrial function and causing oxidative damage. Mitochondria-targeted antioxidants (mito-AOX) have shown promise in protecting against LPS-induced damage and developing new treatment strategies for Gram-negative infections.
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Medicine, General & Internal
Claudia M. Deus, Jose Teixeira, Nuno Raimundo, Paolo Tucci, Fernanda Borges, Luciano Saso, Paulo J. Oliveira
Summary: Parkinson's disease is an incurable neurodegenerative movement disorder characterized by dopaminergic cell neurodegeneration. Oxidative stress, especially mitochondrial dysfunction, plays a crucial role in the pathogenesis of Parkinson's disease. Modulating oxidative stress, particularly using dietary mitochondria-targeted antioxidants, may be a promising approach to prevent or treat Parkinson's disease.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Tarun Pant, Nnamdi Uche, Matea Juric, Zeljko J. Bosnjak
Summary: Metabolic imbalances and persistent hyperglycemia in diabetes mellitus drive the production of reactive oxygen species (ROS), leading to vascular complications. Recent studies show that changes in long non-coding RNA (lncRNA) regulate mitochondrial function in oxidative stress. Mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. This review discusses the potential of lncRNA as a diagnostic biomarker and regulator of oxidative stress in diabetes-associated vascular complications, as well as the use of MTAs in animal models and clinical trials.
Article
Biochemistry & Molecular Biology
Macarena Gonzalez, Tanisha Prashar, Haley Connaughton, Michael Barry, Rebecca Robker, Ryan Rose
Summary: This study investigated the potential of mitochondrial antioxidants to protect sperm quality during cryopreservation. The results showed that the addition of BGP-15 or L-carnitine to the cryopreservation medium improved sperm motility and prevented loss of viability. These antioxidants also reduced DNA oxidative damage, with BGP-15 significantly reducing DNA fragmentation. Overall, this study highlights the importance of mitochondrial antioxidants in improving long-term fertility preservation in males.
Review
Chemistry, Multidisciplinary
Ting Huang, Tianyuan Zhang, Jianqing Gao
Summary: Mitochondria, as the main energy suppliers in cells, play a significant role in regulating cellular processes. Dysfunctional mitochondria have been found to be associated with various diseases, and supplementation of functional mitochondria is considered a potential therapeutic strategy. This review summarizes the latest findings on mitochondrial delivery strategies and provides an overview of the role of mitochondria, mechanisms of intercellular mitochondrial transfer, therapeutic benefits, challenges, and prospects of mitochondrial delivery. Understanding mitochondrial delivery has the potential to improve the therapeutic outcomes of mitochondrial dysfunctional diseases in the future.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Nanoscience & Nanotechnology
Irati Beltran Hernandez, Guillaume C. M. Grinwis, Alessia Di Maggio, Paul M. P. van Bergen en Henegouwen, Wim E. Hennink, Erik Teske, Jan W. Hesselink, Sebastiaan A. van Nimwegen, Jan A. Mol, Sabrina Oliveira
Summary: NB-PDT utilizes nanobodies and photosensitizer to deliver therapeutic agents to cancer cells, causing cell death upon light irradiation. Successful treatment of feline OSCC and identification of EGFR as a relevant target have been demonstrated through experiments.
Article
Biochemistry & Molecular Biology
Kristell Le Gal, Clotilde Wiel, Mohamed X. Ibrahim, Marcus Henricsson, Volkan I. Sayin, Martin O. Bergo
Summary: Research suggests that mitochondria-targeted antioxidants have no anti-cancer effects in malignant melanoma and lung cancer.
Article
Materials Science, Multidisciplinary
Tanveer A. Tabish, Mian Zahid Hussain, Roland A. Fischer, Angela Casini
Summary: Much progress has been made in subcellular targeted therapy of cancer by attacking disease cell's mitochondria. Mitochondrial dysfunction controls key metabolic changes and is related to tumor invasion, proliferation, tumorigenesis, and metastasis. Supramolecular metal-organic frameworks (MOFs) can be targeted to the tumor's mitochondria selectively and disrupt cancer cells' metabolic processes. Mitochondria-targeted MOFs (mitoMOFs) have the potential to revolutionize targeted therapy and improve therapeutic outcomes with minimal side-effects.
Article
Chemistry, Physical
Yuting Fang, Pengcheng Lei, Haoran Xing, Kangli Xu, Maogen Zhu, Zhechen Fan, Kaiwen Qi, Qianyao Wu, Yongchun Zhu
Summary: This study demonstrates the relationship between zinc dendrites formation and the step-edge structure on zinc foil anodes. By using a solvent-controlled replacement reaction, the step edges can be chemically flattened, leading to uniform zinc deposition without dendrites growth. Additionally, the generated zinc fluoride can be embedded in polyvinylidene fluoride to act as a protective layer against corrosion on the zinc foil surface. Experimental results show that this treatment method enables dendrite-free and corrosion-free zinc plating in batteries.
ENERGY STORAGE MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Xin Liu, Xiaofan Wang, Jing Chang, Hongmin Zhang, Pengxiu Cao
Summary: Oxidative stress, caused by an imbalance in oxidant/antioxidant processes, plays a critical role in pulmonary diseases. The relationship between oxidative stress and pulmonary diseases needs to be comprehensively studied to identify effective therapeutics. This review analyzed publications related to oxidative stress and pulmonary diseases over four periods, revealing the association between oxidative stress and lung injury, lung cancer, asthma, COPD, and pneumonia. Antioxidants, targeting reactive oxygen species (ROS), may be an important choice in combined therapies for refractory pulmonary diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Karina-Alexandra Cojocaru, Ionut Luchian, Ancuta Goriuc, Lucian-Mihai Antoci, Cristian-Gabriel Ciobanu, Roxana Popescu, Cristiana-Elena Vlad, Mihaela Blaj, Liliana Georgeta Foia
Summary: Mitochondria play crucial roles in cellular functions, including calcium regulation, apoptosis, and reactive oxygen species production. They are involved in important biochemical pathways and are responsible for the majority of cellular ATP production. Mitochondrial dysfunction is associated with various metabolic disorders, neurodegenerative diseases, aging, and cancer. This article discusses the pathophysiological changes and mitochondrial involvement in metabolic disorders, highlighting genetic changes at the mtDNA level and summarizing progress in therapeutic strategies.
Article
Nutrition & Dietetics
Junquan Tian, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yuying Li, Kang Yao, Yulong Yin
Summary: Age-related osteoporosis is a common disease in the elderly, mainly caused by excessive activity of osteoclasts. Most approved drugs inhibit osteoclasts to treat osteoporosis. This study shows that supplementing dimethyl alpha-ketoglutarate (DM-AKG) can inhibit the differentiation of osteoclasts. The mechanism involves regulating NF-kappa B signaling pathway and oxidative phosphorylation through PHD1-dependent manner.
Article
Nutrition & Dietetics
Tao Wang, Junquan Tian, Wenxuan Su, Fan Yang, Jie Yin, Qian Jiang, Yuying Li, Kang Yao, Tiejun Li, Yulong Yin
Summary: This study evaluated the optimal dosage of ornithine a-ketoglutarate (OKG) and explored its preventive effect on DSS-induced colitis in mice. Results showed that 1% OKG supplementation increased body weight, serum growth hormone (GH), insulin (INS), alkaline phosphatase (ALP), and certain amino acids, while decreasing urea nitrogen (BUN), NH3L, and Ile. Moreover, 1% OKG supplementation prevented DSS-induced colitis in mice by altering microbial compositions and reducing the secretion of inflammatory cytokines in serum.
Article
Cell & Tissue Engineering
Junquan Tian, Yuying Li, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Yulong Yin, Kang Yao
Summary: Early weaning inhibits the self-renewal and function of intestinal stem cells, leading to intestinal atrophy. This is potentially due to the suppression of Wnt signaling and activation of proinflammatory cytokines. These findings may offer a potential therapeutic approach for alleviating intestinal problems caused by early weaning.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Junquan Tian, Yuying Li, Xuetai Bao, Fan Yang, Xiongzhuo Tang, Qian Jiang, Chengbo Yang, Yulong Yin, Kang Yao
Summary: Early weaning disrupts intestinal epithelial development and increases the risk of gastrointestinal diseases. Glutamine (Gln), found in plasma and milk, has been reported to have positive effects on intestinal health. This study investigated the impact of Gln on intestinal stem cell (ISC) activity in response to early weaning. The results show that Gln improves early weaning-induced epithelial atrophy and enhances ISC-mediated epithelial regeneration by augmenting WNT signaling.
Article
Agriculture, Dairy & Animal Science
Junquan Tian, Fan Yang, Xuetai Bao, Qian Jiang, Yuying Li, Kang Yao, Yulong Yin
Summary: Intensive farming in the pig industry has led to an increase in phosphorus pollution. Dietary strategies to improve bone growth, such as the supplementation of alpha-ketoglutarate, can optimize the utilization of dietary phosphorus and reduce its release into the environment. This study found that dietary alpha-ketoglutarate supplementation improves bone growth and enhances the digestibility of phosphorus and calcium in piglets' diets. These findings may offer a nutritional strategy for reducing phosphorus pollution from the pig industry.
Review
Biochemistry & Molecular Biology
Meng Li, Mengqi Qian, Qian Jiang, Bie Tan, Yulong Yin, Xinyan Han
Summary: A growing body of evidence highlights the disease-preventative properties of flavonoids in natural foods. This review introduces the classification, sources, and properties of flavonoids, and summarizes the experimental results and molecular mechanisms regarding the effects of flavonoid consumption on obesity, cancers, and neurogenerative diseases that pose significant public health threats. The dosage and duration of flavonoid intervention in these diseases are discussed, providing guidance for healthy dietary habits for individuals with different physical statuses.
Article
Biochemistry & Molecular Biology
Zhaojie Wang, Qian Jiang, Pingping Li, Panpan Shi, Chao Liu, Wenmao Wang, Ke Huang, Yulong Yin, Peng Huang
Summary: This study explores the potential benefits of using Ampelopsis grossedentata as an antioxidant and anti-inflammatory agent in the context of intestinal inflammation. The results show that Ampelopsis grossedentata exhibits a protective effect on the intestinal barrier function and effectively alleviates oxidative stress and inflammation in animal models. Additionally, it regulates gut microbiota, promoting the growth of beneficial bacteria and inhibiting harmful microbes. These findings suggest that Ampelopsis grossedentata may serve as a valuable dietary supplement for addressing oxidative stress and inflammation.
Article
Agriculture, Dairy & Animal Science
Shengting Deng, Chengkun Fang, Ruiwen Zhuo, Qian Jiang, Yating Song, Kaili Yang, Sha Zhang, Juanyi Hao, Rejun Fang
Summary: Iron complexation of polysaccharides has gained attention in glycobiology research. This study investigated the effects of maternal supplementation with tapioca polysaccharide iron (TpFe) on reproductive performance, colostrum composition, cord blood active components, and growth performance of nursing piglets. The results demonstrated that TpFe supplementation improved feed intake, reproductive performance, colostrum composition, antioxidant and immunological performance, and growth performance in piglets. The findings highlight the potential benefits of TpFe as a natural compound for enhancing piglet production performance.
Article
Agriculture, Dairy & Animal Science
Shengwang Jiang, Chaoyun Yang, Yintao Xiao, Saizhen Zheng, Qian Jiang, Jiashun Chen
Summary: This study investigated the effects of dietary supplementation with Gracilaria lemaneiformis polysaccharides (GLPs) on the growth performance, antioxidant capacity, immune function, and meat quality of broiler chickens. The results showed that dietary supplementation with 2,000 mg/kg GLPs improved broiler growth performance, antioxidant capacity, immune function, and the composition of gut microbiota.
JOURNAL OF POULTRY SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Yiming Wu, Chongqi Zhao, Guanzhong Song, Haibo Shen, Xilong Li, Xiaokang Ma, Bie Tan, Yulong Yin, Qian Jiang
Summary: This study reports the procedures for obtaining a bacterial consortium YM-1 from the intestines of free-range chickens by anaerobic culture. YM-1 was able to effectively de-epoxidize DON by 99.2% within 24 hours under an anaerobic condition. The products of DON degraded by YM-1, mainly consisting of DOM-1, were validated to be non-toxic to the IPEC-J2 cells, indicating the potential use of YM-1 as a bio-agent for DON decontamination.
ANNALS OF AGRICULTURAL SCIENCES
(2023)
Review
Agriculture, Dairy & Animal Science
Nian Liu, Haibo Shen, Fan Zhang, Xiang Liu, Qinrui Xiao, Qian Jiang, Bie Tan, Xiaokang Ma
Summary: Oligosaccharides are low molecular weight carbohydrates that have various health benefits, including promoting growth, regulating immunity, improving intestinal flora, and possessing anti-inflammatory and antioxidant properties. They are classified into common oligosaccharides, which are easily absorbed by the intestine, and functional oligosaccharides, which are not easily absorbed and have special physiological functions. This review provides a theoretical basis for further research on functional oligosaccharides and their potential application in replacing antibiotics in the pig industry.
Article
Agriculture, Dairy & Animal Science
Zhe Yang, Fang Wang, Yexin Yin, Peng Huang, Qian Jiang, Zhimou Liu, Yulong Yin, Jiashun Chen
Summary: This study aimed to determine the effects of dietary Litsea cubeba essential oil (LEO) supplementation on various aspects of weaned piglets. The results showed that high-dose LEO supplementation improved growth performance, immune function, antioxidant level, intestinal morphology, and microbial composition. LEO supplementation also increased the concentration of short chain fatty acids in the cecum and colon.
Article
Biotechnology & Applied Microbiology
Cong Li, Longteng Ma, Lifen Wang, Zixi Zhang, Yuguang Chen, Jiashun Chen, Qian Jiang, Zehe Song, Xi He, Bie Tan, Dingfu Xiao, Xiaokang Ma
Summary: The current study aimed to investigate the solid-state fermentation process of Quercus liaotungensis (QL) by Bacillus subtilis (BS). The optimal process was determined based on the nutritional value, tannin content and DPPH clearance of QL after fermentation. The results showed that the QL significantly improved the nutritional value after solid-state fermentation with BS.
FERMENTATION-BASEL
(2023)
