期刊
ORGANIC LETTERS
卷 23, 期 3, 页码 930-935出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c04133
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资金
- Recruitment Program of Global Experts
- Shanghai Jiao Tong University
A regio-, chemo-, and enantioselective nickel-catalyzed hydrocyanation of 1,3-dienes has been achieved by using a specific multichiral diphosphite ligand. Besides aryl-substituted 1,3-dienes, challenging aliphatic 1,3-diene substrates can also be selectively converted to the corresponding 1,2-adducts with high yields and the highest enantioselectivities to date.
A regio-, chemo-, and enantioselective nickel-catalyzed hydrocyanation of 1,3-dienes is reported. The key to the success of this asymmetric transformation is the use of a specific multichiral diphosphite ligand. In addition to aryl-substituted 1,3-dienes, highly challenging aliphatic 1,3-diene substrates can also be preferentially converted to the corresponding 1,2-adducts in decent yields with the highest enantioselectivities to date.
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