Article
Biochemistry & Molecular Biology
Elisabeth M. Haberl, Thomas S. Weiss, Georg Peschel, Kilian Weigand, Nikolai Koehler, Josch K. Pauling, Juergen J. Wenzel, Marcus Hoering, Sabrina Krautbauer, Gerhard Liebisch, Christa Buechler
Summary: The study revealed differences in lipid metabolism between liver cancer tissues and non-tumor liver tissues, as well as in the impact of HBV and HCV infections on hepatic lipid concentrations. The tumor suppressor protein p53 showed a negative correlation with free cholesterol in tumors, indicating its role in cholesterol metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Dario Magaquian, Susana Delgado Ocana, Consuelo Perez, Claudia Banchio
Summary: Neuroinflammation does not affect NSCs proliferation but induces aberrant neuronal differentiation, leading to dystrophic, non-functional neurons. PtdCho-enriched media can enhance neuronal differentiation under inflammatory stress, increasing the population of healthy normal neurons and ameliorating neuronal damage to modulate neuronal plasticity. These findings contribute to understanding NSCs behavior under inflammatory conditions and offer new avenues for improving neurogenic capacity in the brain.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Qiujian Yu, Xiaoqin Cheng
Summary: This study aimed to propose membrane aging as a critical pathogenesis of Alzheimer's disease (AD) and established a hydroxyurea-induced membrane aging model to further prove this hypothesis.
Article
Clinical Neurology
Jingjing Xu, Xiaochen Huang, Yujie Guo, Xiaojun Ma, Pengfei Li, Shaobo Zhou, Chi Zhang, Rui Chen, Nicholas Van Halm-Lutterodt, Linhong Yuan
Summary: This study investigated the effects of ApoE deficiency and DHA treatment on brain Aβ and lipid levels. The results showed that DHA treatment had different impacts on brain lipid and Aβ metabolism in ApoE-deficient and wild-type mice, suggesting a modifying role of ApoE status on the responses to DHA treatment.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2023)
Article
Chemistry, Applied
Changfeng Hu, Jingyi Song, Wumeng Jin, Wenqiang Wang, Hongjin Bai, Cuiyun Wu, Lirong Shen
Summary: Walnut oil, rich in polyunsaturated fatty acids, has many health benefits. The synthesis and accumulation of walnut oil in the embryo development process may be influenced by a special mechanism for triacylglycerol biosynthesis. Shotgun lipidomics analysis revealed that triacylglycerol synthesis in walnut kernels occurred before 84 days after flowering and was enhanced between 84 and 98 days. Acyl editing through phosphatidylcholine played a role in the flux of fatty acids for triacylglycerol synthesis. Therefore, triacylglycerol biosynthesis in walnut kernels is directly linked to lipid metabolism.
Article
Biochemistry & Molecular Biology
Yang Bai, Xiaofang Zhu, Xinya Guo, Wenhua Zhang, Guozheng Zhang, Huatao Chen, Qun Zhang
Summary: The study isolated and characterized two AAPTs, GmAAPT1 and GmAAPT2, from soybeans, which showed strong similarity in amino acid contents and expression patterns and were found to localize to the endoplasmic reticulum and Golgi apparatus. In vitro enzymatic analyses revealed that GmAAPT1 and GmAAPT2 contributed to PC and PE synthesis, playing a role in regulating seed TAG and polyunsaturated fatty acid levels. Overexpression of GmAAPT1 and GmAAPT2 in Arabidopsis resulted in decreased seed TAG and polyunsaturated fatty acids levels, leading to reduced seed germination under freezing stress. This suggests that GmAAPTs mediate TAG metabolism and negatively regulate seed freezing tolerance.
PLANT SIGNALING & BEHAVIOR
(2021)
Article
Chemistry, Applied
Robbe Demets, Lore Gheysen, Ann Van Loey, Imogen Foubert
Summary: This research investigates the role of carotenoids in the oxidative stability of mixtures of fish oil and lipid extracts of two different microalgae. It finds that the initial amount of carotenoids relative to n-3 LC-PUFA is a good indicator to differentiate between oxidatively stable and unstable mixtures. The degradation of fucoxanthin, diatoxanthin, and beta-carotene during storage illustrates their antioxidative role.
Article
Biochemistry & Molecular Biology
Kiryl Zhaliazka, Mikhail Matveyenka, Dmitry Kurouski
Summary: Abrupt aggregation of amyloid beta(1-42) (Aβ) peptide is a hallmark of Alzheimer's disease (AD), and lipids have been found to uniquely alter the rate and structure of Aβ(1-42) aggregation. In this study, the effect of phosphatidylcholine (PC), cardiolipin (CL), and cholesterol (Chol) on Aβ(1-42) aggregation was investigated. The results showed that these lipids significantly accelerated the rate of fibril formation and modified the secondary structure of Aβ(1-42) aggregates.
Article
Food Science & Technology
Xiaodan Lu, Luyao Huang, Yanjun Chen, Ling Hu, Rongbin Zhong, Lijiao Chen, Wenjian Cheng, Baodong Zheng, Peng Liang
Summary: Lipid metabolism disorder is a significant threat to human health, and various supplements have been studied to treat it. This study focused on the effect of DHA-enriched phospholipids from large yellow croaker roe (LYCRPLs) on lipid regulation in rats, specifically analyzing the fecal metabolites using metabolomics. The results showed that LYCRPLs activated several metabolic pathways related to lipid metabolism, and L-cysteine was identified as a potential biomarker for LYCRPLs' effects on rat fecal metabolites.
Article
Chemistry, Applied
Eija Ahonen, Annelie Damerau, Jukka-Pekka Suomela, Maaria Kortesniemi, Kaisa M. Linderborg
Summary: This study investigated the oxidative stability, alpha-tocopherol response, and oxidation pattern of DHA in different lipid structures. It found that DHA was more stable in triacylglycerols than as ethyl esters, but the addition of alpha-tocopherol reversed this trend. The oxidation products formed were mostly similar between the two lipid structures, but some structure-related differences were also detected.
Article
Nutrition & Dietetics
Liana L. Guarneiri, Meredith L. Wilcox, Kevin C. Maki
Summary: This study aimed to evaluate the bioavailability of EPA+DHA in a phospholipid-enhanced fish oil product and a krill oil product. Results showed similar absorption of EPA+DHA from both products, but with different absorption profiles, with the phospholipid-enhanced fish oil product having a higher and earlier peak concentration.
Article
Cell Biology
Etienne Deragon, Martin Schuler, Riccardo Aiese Cigliano, Younes Dellero, Gregory Si Larbi, Denis Falconet, Juliette Jouhet, Eric Marechal, Morgane Michaud, Alberto Amato, Fabrice Rebeille
Summary: Thraustochytrids are marine protists that naturally accumulate triacylglycerol with long chains of polyunsaturated fatty acids, such as DHA. Through genome sequencing and metabolic analysis, a peroxisomal adenylate transporter gene (AlANT1) was found to be associated with DHA accumulation in Thraustochytrids, providing a new approach to enhance DHA production in these organisms.
Article
Food Science & Technology
Ann-Dorit Moltke SOrensen, Adane Tilahun Getachew, Charlotte Jacobsen
Summary: The study found that starfish could be a potential source of marine oil containing omega-3 fatty acids and phospholipids, however, the extraction method still needs further optimization.
Article
Food Science & Technology
Hongxia Che, Hongyan Li, Lin Song, Xiufang Dong, Xihong Yang, Tiantian Zhang, Yuming Wang, Wancui Xie
Summary: Research comparing the effects of DHA-PL and DHA-TG on inflammatory bowel disease revealed both could reverse colitis and regulate gut microbiota. However, DHA-PL showed advantages in regulating oxidative stress, inflammatory responses, and intestinal barrier permeability, potentially making it a more effective choice for preventing and treating colitis.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.