期刊
NEW PHYTOLOGIST
卷 229, 期 3, 页码 1261-1267出版社
WILEY
DOI: 10.1111/nph.17034
关键词
AtGLR3.3 ligand-binding domain structure; glutamate receptor-like channels; long-distance calcium signalling; plant intercellular communication; vascular tissues
资金
- Piano di Sviluppo di Ateneo 2019 (University of Milan)
- Ministero dell'Istruzione, dell'Universita e della Ricerca Fondo per Progetti di ricerca di Rilevante Interesse Nazionale 2017 [PRIN 2017ZBBYNC]
- Department of Biosciences (University of Milan)
- University of Milan
Recent studies have highlighted the physiological role of plant glutamate receptor-like channels (GLRs), but the mechanisms of activation and the physiological significance of amino acid binding are still unclear. Recent biochemical and structural evidence regarding Arabidopsis thaliana GLR3.3 isoform binding to glutamate and other amino acids provides a foundation for better understanding the activation and modulation of GLRs in various physiological responses.
In recent years, studies have shed light on the physiological role of plant glutamate receptor-like channels (GLRs). However, the mechanism by which these channels are activated, and in particular, what is the physiological role of their binding to amino acids, remains elusive. The first direct biochemical demonstration that the Arabidopsis thaliana GLR3.3 isoform binds glutamate and other amino acids in a low micromolar range of concentrations was reported only recently. The first crystal structures of the ligand-binding domains of AtGLR3.3 and AtGLR3.2 isoforms also have been released. We foresee that these new experimental pieces of evidence provide the basis for a better understanding of how GLRs are activated and modulated in different physiological responses.
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