Article
Immunology
Ben Bassett, Selvaraj Subramaniyam, Yang Fan, Seth Varney, Hope Pan, Ana M. D. Carneiro, Chang Y. Chung
Summary: Minocycline shows promising results in alleviating depressive-like behaviors induced by chronic mild stress, potentially by directly acting on microglia to reduce their phagocytic potential and reverse the pathogenic phagocytic potential of neurotoxic M1 microglia. This mechanism may help reduce negative phenotypes associated with reduced neurogenesis caused by exposure to chronic stress.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Medicine, Research & Experimental
Kuo Zhang, Fan Wang, Mengying Zhai, Meiyao He, Yuxuan Hu, Lijin Feng, Yuting Li, Jingyu Yang, Chunfu Wu
Summary: Chronic stress can induce depressive-like behavior and inhibit adult hippocampal neurogenesis. Chronic corticosterone treatment decreases the proliferation and survival of neural stem cells, impairs the migration of newborn neurons, and increases neuronal autophagy. Inhibiting hyperactive neuronal autophagy can reverse the decrease in neuronal brain-derived neurotrophic factor levels, rescue neurogenesis, and exert antidepressant effects.
Review
Immunology
Shaoyi Fang, Zhibin Wu, Yali Guo, Wenjun Zhu, Chunmiao Wan, Naijun Yuan, Jianbei Chen, Wenzhi Hao, Xiaowei Mo, Xiaofang Guo, Lili Fan, Xiaojuan Li, Jiaxu Chen
Summary: This review explores the roles of adult hippocampal neurogenesis and microglia in the etiology of depression, and discusses the mechanisms by which microglia regulate adult hippocampal neurogenesis in depression and potential drugs for improving neurogenesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elif Tunc-Ozcan, Sarah M. Brooker, Jacqueline A. Bonds, Yung-Hsu Tsai, Radhika Rawat, Tammy L. McGuire, Chian-Yu Peng, John A. Kessler
Summary: Hippocampal BMP signaling is identified as a common pathway mediating the behavioral effects of multiple antidepressant classes and electroconvulsive therapy. Inhibition of hippocampal BMP signaling is shown to be both necessary and sufficient to mediate the effects of these treatments, involving a key role in neurogenesis in the hippocampus.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Chen-xin Li, Ying Zheng, Hong Zhu, Cheng-wu Li, Zhang He, Cong Wang, Jian-hua Ding, Gang Hu, Ming Lu
Summary: The study highlights the crucial role of beta-arrestin2 in the therapeutic effects of fluoxetine on depression, potentially through the modulation of neurogenesis via the 5-HT receptor-beta-arrestin axis. Deletion of beta-arrestin2 affected mouse behaviors and neurotransmitter levels, without exacerbating changes induced by chronic mild stress, and also impacted dendritic morphology and proliferating cells.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Immunology
Ayla Batu Ozturk, Nail Can Ozturk, Furkan Ayaz
Summary: Many neurodegenerative diseases show neuroinflammation and impaired neuron production in the hippocampus. Immunotherapeutic strategies targeting microglia may be problematic. Instructing monocytes/macrophages from the periphery could be a less invasive strategy. However, the interaction between CNS neurons and macrophages is poorly understood.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Barbara Planchez, Natalia Lagunas, Anne-Marie Le Guisquet, Marc Legrand, Alexandre Surget, Rene Hen, Catherine Belzung
Summary: Studies have shown that increasing adult hippocampal neurogenesis can promote stress resilience and prevent the development of stress-induced depressive-like symptoms.
Article
Immunology
Yi Luo, Keyi Lv, Zhulin Du, Dandan Zhang, Mei Chen, Jing Luo, Lian Wang, Tianyao Liu, Hong Gong, Xiaotang Fan
Summary: Autism spectrum disorder (ASD) lacks effective pharmacological treatments. Minocycline, known for its anti-inflammatory properties and neuroprotective effects, inhibits microglial activation. This study used a mouse model of autism and found that minocycline administration improved ASD-like behaviors, neurogenesis, and inhibited microglia activation. These findings suggest that minocycline supplementation might be a potential strategy for improving ASD symptoms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Qiu-Qin Han, Shi-Yu Shen, Xiao-Rong Chen, Adam Pilot, Ling-Feng Liang, Jia-Rui Zhang, Wen-Hui Li, Yi Fu, Jia-Mei Le, Pei-Qing Chen, Jin Yu
Summary: The activated microglia may abnormally engulf neuronal synapses under depressive pathological conditions, leading to synaptic loss and behavioral impairments. Inhibiting microglial phagocytosis can reverse synaptic loss and alleviate behavioral impairments.
Article
Behavioral Sciences
Liang Liu, Er-Qiang Wang, Cheng Du, Hui-Sheng Chen, Yan Lv
Summary: The study showed that minocycline treatment improved cognitive and mood function in a rat model of GWI by reversing gut microbiome alterations, neuroinflammation, and decreased hippocampal neurogenesis. This suggests that minocycline may serve as a potential prophylactic or therapeutic agent for GWI treatment.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Wu Jiang, Yi-Yun Tang, Wei-Wen Zhu, Cheng Li, Ping Zhang, Run-Qi Li, Yong-Jun Chen, Wei Zou, Xiao-Qing Tang
Summary: The study demonstrates that hydrogen sulfide improves depression- and anxiety-like behaviors in diabetic rats by activating the hippocampal PI3K/AKT pathway and enhancing hippocampal neurogenesis. This finding enhances our understanding of the therapeutic potential of hydrogen sulfide as a treatment strategy for depression in diabetes mellitus.
Article
Cell Biology
Chong Gao, Meiling Wu, Qiaohui Du, Jiagang Deng, Jiangang Shen
Summary: This study found that naringin promotes adult hippocampal neurogenesis and improves depression-like behaviors by regulating the BDNF/TrkB/CREB signaling pathway. The results showed that naringin enhances the proliferation of neural stem/progenitor cells and accelerates neuronal differentiation, and its antidepressant and anxiolytic effects are attributed to enhanced hippocampal neurogenesis via activating CREB signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Kelli Somelar, Monika Jurgenson, Kulli Jaako, Kaili Anier, Anu Aonurm-Helm, Liga Zvejniece, Alexander Zharkovsky
Summary: Chronic pain may lead to depression, and in rodent models of neuropathic pain, reduced neurogenesis in the hippocampus is associated with the development of affective disorders. Our study revealed that neuropathic pain induces long-term changes in hippocampal plasticity, specifically a reduction in mature functional neurons.
Article
Cell Biology
Jose Erik Alvarez-Contino, Estela Diaz-Sanchez, Marina Mirchandani-Duque, Jose Andres Sanchez-Perez, Miguel A. Barbancho, Alexander Lopez-Salas, Natalia Garcia-Casares, Kjell Fuxe, Dasiel O. Borroto-Escuela, Manuel Narvaez
Summary: This study found that intranasal infusion of GALR2 and Y1R agonists promotes neuroblast proliferation and induces the expression of the neurotrophic factor BDNF in the ventral hippocampus, resulting in antidepressant effects. These effects may be mediated by increased formation of Y1R-GALR2 heteroreceptor complexes. These findings may provide a new approach for the development of novel therapies for major depressive disorder.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Clinical Neurology
Hui Wang, Liang Liang, Can Yang, Ling Xiao, Huiling Wang, Gaohua Wang, Zhixian Zhu
Summary: This study found that low-density lipoprotein receptor-related protein 1 (LRP1) in the hippocampus of rats is positively correlated with depressive-like behaviors. Administration of LRP1 improved depressive-like behaviors, while LRP1 knockdown alleviated the inhibition of synaptic plasticity induced by chronic unpredicted mild stress (CUMS). Furthermore, LRP1 knockdown increased synaptic plasticity through microtubule dynamics and activation of the Akt/GSK-3 beta signaling pathway. These findings suggest that LRP1 may serve as a potential therapeutic target for depression.
JOURNAL OF AFFECTIVE DISORDERS
(2023)