High-Contrast In Vivo Imaging of Tau Pathologies in Alzheimer’s and Non-Alzheimer’s Disease Tauopathies

Novel tau filament fold in corticobasal degeneration

(2020) Wenjuan Zhang et al.   NATURE

Corticobasal degeneration with deep white matter lesion diagnosed by brain biopsy

(2020) Akira Arakawa et al.   NEUROPATHOLOGY

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders

(2020) Antoine Leuzy et al.   JAMA Neurology

Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue

(2019) Cinthya Aguero et al.   Acta Neuropathologica Communications

In vivo binding of a tau imaging probe, [ 11 C]PBB3, in patients with progressive supranuclear palsy

(2019) Hironobu Endo et al.   MOVEMENT DISORDERS

Cellular and regional vulnerability in frontotemporal tauopathies

(2019) Shelley L. Forrest et al.   ACTA NEUROPATHOLOGICA

Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer’s disease and other tauopathies

(2019) Heiko Kroth et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury

(2019) Keisuke Takahata et al.   BRAIN

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

(2019) Tobey J Betthauser et al.   BRAIN

Different Positron Emission Tomography Tau Tracers Bind to Multiple Binding Sites on the Tau Fibril: Insight from Computational Modeling

(2018) N. Arul Murugan et al.   ACS Chemical Neuroscience

Non-Alzheimer’s contributions to dementia and cognitive resilience in The 90+ Study

(2018) John L. Robinson et al.   ACTA NEUROPATHOLOGICA

Longitudinal tau PET in ageing and Alzheimer’s disease

(2018) Clifford R Jack et al.   BRAIN

Preclinical, phase I, and phase II investigational clinical trials for treatment of progressive supranuclear palsy

(2018) Ali Shoeibi et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

18F-Flortaucipir Binding in Choroid Plexus: Related to Race and Hippocampus Signal

(2018) Christopher M. Lee et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vivo Visualization of Tau Accumulation, Microglial Activation, and Brain Atrophy in a Mouse Model of Tauopathy rTg4510

(2018) Ai Ishikawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Comparative In Vitro and In Vivo Quantifications of Pathologic Tau Deposits and Their Association with Neurodegeneration in Tauopathy Mouse Models

(2018) Ruiqing Ni et al.   JOURNAL OF NUCLEAR MEDICINE

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

[18F]-THK5351 PET Correlates with Topology and Symptom Severity in Progressive Supranuclear Palsy

(2018) Matthias Brendel et al.   Frontiers in Aging Neuroscience

Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808

(2018) David T. Chien et al.   JOURNAL OF ALZHEIMERS DISEASE

Assessing the Performance of MM/PBSA, MM/GBSA, and QM–MM/GBSA Approaches on Protein/Carbohydrate Complexes: Effect of Implicit Solvent Models, QM Methods, and Entropic Contributions

(2018) Sushil K. Mishra et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

In vivo quantification of neurofibrillary tangles with [18F]MK-6240

(2018) Tharick A. Pascoal et al.   Alzheimers Research & Therapy

Distinct roles for each N-glycan branch interacting with mannose-binding type Jacalin-related lectins Orysata and Calsepa

(2017) Masamichi Nagae et al.   GLYCOBIOLOGY

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Correlations of18F-THK5351 PET with Postmortem Burden of Tau and Astrogliosis in Alzheimer Disease

(2017) Ryuichi Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Preclinical Evaluation of18F-RO6958948,11C-RO6931643, and11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

(2017) Michael Honer et al.   JOURNAL OF NUCLEAR MEDICINE

Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria

(2017) Günter U. Höglinger et al.   MOVEMENT DISORDERS

The tau positron-emission tomography tracer AV-1451 binds with similar affinities to tau fibrils and monoamine oxidases

(2017) Céline Vermeiren et al.   MOVEMENT DISORDERS

Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain

(2017) Kok Pin Ng et al.   Alzheimers Research & Therapy

In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum

(2016) Hanna Cho et al.   ANNALS OF NEUROLOGY

[F-18]AV-1451 positron emission tomography retention in choroid plexus: More than “off-target” binding

(2016) Milos D. Ikonomovic et al.   ANNALS OF NEUROLOGY

Inter-rater variability of visual interpretation and comparison with quantitative evaluation of 11C-PiB PET amyloid images of the Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI) multicenter study

(2016) Tomohiko Yamane et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

Cerebellar ataxia in progressive supranuclear palsy: An autopsy study of PSP-C

(2016) Shunsuke Koga et al.   MOVEMENT DISORDERS

In vivo visualization of tau deposits in corticobasal syndrome by 18 F-THK5351 PET

(2016) Akio Kikuchi et al.   NEUROLOGY

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

A new method to quantify tau pathologies with 11C-PBB3 PET using reference tissue voxels extracted from brain cortical gray matter

(2016) Yasuyuki Kimura et al.   EJNMMI Research

An autoradiographic evaluation of AV-1451 Tau PET in dementia

(2016) Val J. Lowe et al.   Acta Neuropathologica Communications

Neurodegenerative Diseases: Expanding the Prion Concept

(2015) Lary C. Walker et al.   Annual Review of Neuroscience

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

PET Quantification of Tau Pathology in Human Brain with 11C-PBB3

(2015) Y. Kimura et al.   JOURNAL OF NUCLEAR MEDICINE

18F-THK5351: A Novel PET Radiotracer for Imaging Neurofibrillary Pathology in Alzheimer Disease

(2015) R. Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Identification of a major radiometabolite of [ 11 C]PBB3

(2015) Hiroki Hashimoto et al.   NUCLEAR MEDICINE AND BIOLOGY

A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis

(2014) Susana Boluda et al.   ACTA NEUROPATHOLOGICA

Radiosynthesis, Photoisomerization, Biodistribution, and Metabolite Analysis of 11C-PBB3 as a Clinically Useful PET Probe for Imaging of Tau Pathology

(2014) H. Hashimoto et al.   JOURNAL OF NUCLEAR MEDICINE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study

(2013) Naruhiko Sahara et al.   NEUROBIOLOGY OF AGING

Criteria for the diagnosis of corticobasal degeneration

(2013) M. J. Armstrong et al.   NEUROLOGY

Imaging of Tau Pathology in a Tauopathy Mouse Model and in Alzheimer Patients Compared to Normal Controls

(2013) Masahiro Maruyama et al.   NEURON

Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old

(2011) John L. Robinson et al.   BRAIN

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

In Vivo Positron Emission Tomographic Imaging of Glial Responses to Amyloid-  and Tau Pathologies in Mouse Models of Alzheimer's Disease and Related Disorders

(2011) J. Maeda et al.   JOURNAL OF NEUROSCIENCE

Corticobasal degeneration: a pathologically distinct 4R tauopathy

(2011) Naomi Kouri et al.   Nature Reviews Neurology

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Frontotemporal Lobar Degeneration

(2010) Gil D. Rabinovici et al.   CNS DRUGS

Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges

(2009) David R Williams et al.   LANCET NEUROLOGY

Cerebellar involvement in progressive supranuclear palsy: A clinicopathological study

(2009) Masato Kanazawa et al.   MOVEMENT DISORDERS

Progression of hippocampal degeneration in amyotrophic lateral sclerosis with or without memory impairment: distinction from Alzheimer disease

(2008) Takahiro Takeda et al.   ACTA NEUROPATHOLOGICA