期刊
NEUROLOGICAL SCIENCES
卷 42, 期 3, 页码 773-785出版社
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-020-04964-8
关键词
Coronavirus; COVID-19; Neuro-COVID syndrome; neuroinvasion; neurological manifestations; SARS-CoV-2
SARS-CoV-2 infection causing COVID-19 has neurological manifestations, ranging from headaches and dizziness to taste or smell dysfunction. Some cases may initially present with purely neurological symptoms, followed by non-neurological symptoms a few days later.
SARS-CoV-2 infection, resulting in Coronavirus disease 2019 (COVID-19), has significantly affected the entire world. It was labelled a pandemic by World Health Organization. Although it commonly produces respiratory symptoms, neurological features have been described. Neurological manifestations may vary from non-specific symptoms such as headache, dizziness, myalgia and/or fatigue, olfactory or taste dysfunction to specific syndromes including meningitis, stroke, acute transverse myelitis and Guillain-Barre syndrome. This review describes potential pathogenetic mechanisms and neurological manifestations of COVID-19 along with its management. Considering structural and pathogenetic similarity of SARS-CoV-2 with SARS-CoV and MERS viruses, we compared their neurological manifestations and mentioned few features expected in COVID-19 in future. Interestingly, many COVID-19 cases may present with pure neurological manifestations at onset with non-neurological features manifesting few days later and we propose the term Neuro-COVID syndrome for such cases. Awareness of neurological manifestations may facilitate its management and improve outcome in such patients.
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