Stabilization of microtubules improves cognitive functions and axonal transport of mitochondria in Alzheimer's disease model mice

Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway

(2020) Xiao-Ling Wang et al.   Aging-US

Mitochondrial dysfunction in Alzheimer's disease: Role in pathogenesis and novel therapeutic opportunities

(2019) Judit M. Perez Ortiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy

(2019) Jacob A. Ross et al.   ACTA NEUROPATHOLOGICA

Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies

(2019) Anuradha Venkatramani et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chinese Herbal Medicine Xueshuantong Enhances Cerebral Blood Flow and Improves Neural Functions in Alzheimer’s Disease Mice

(2018) Yangmei Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Synaptic loss in schizophrenia: a meta-analysis and systematic review of synaptic protein and mRNA measures

(2018) Emanuele Felice Osimo et al.   MOLECULAR PSYCHIATRY

Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies

(2018) Qiong Xiang et al.   TECHNOLOGY AND HEALTH CARE

Early disruption of parvalbumin expression and perineuronal nets in the hippocampus of the Tg2576 mouse model of Alzheimer's disease can be rescued by enriched environment

(2018) Vanessa Cattaud et al.   NEUROBIOLOGY OF AGING

GSK3β-mediated tau hyperphosphorylation triggers diabetic retinal neurodegeneration by disrupting synaptic and mitochondrial functions

(2018) Huazhang Zhu et al.   Molecular Neurodegeneration

Core Concept: Perineuronal nets gain prominence for their role in learning, memory, and plasticity

(2018) Helen H. Shen   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synaptic Plasticity, Engrams, and Network Oscillations in Amygdala Circuits for Storage and Retrieval of Emotional Memories

(2017) Marco Bocchio et al.   NEURON

Removal of perineuronal nets disrupts recall of a remote fear memory

(2017) Elise Holter Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(iii) complexes

(2017) Jian-Jun Cao et al.   Chemical Science

Synaptic Ensemble Underlying the Selection and Consolidation of Neuronal Circuits during Learning

(2017) Yoshio Hoshiba et al.   Frontiers in Neural Circuits

Mitochondrial traffic jams in Alzheimer's disease - pinpointing the roadblocks

(2016) Sónia C. Correia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Tau and tauopathies

(2016) Thomas Arendt et al.   BRAIN RESEARCH BULLETIN

Higher-Order Sensory Cortex Drives Basolateral Amygdala Activity during the Recall of Remote, but Not Recently Learned Fearful Memories

(2016) Marco Cambiaghi et al.   JOURNAL OF NEUROSCIENCE

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D

(2016) Lorène Penazzi et al.   NEUROPHARMACOLOGY

Reduced Labeling of Parvalbumin Neurons and Perineuronal Nets in the Dorsolateral Prefrontal Cortex of Subjects with Schizophrenia

(2016) John F Enwright et al.   NEUROPSYCHOPHARMACOLOGY

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology

(2015) Sujeong Yang et al.   EXPERIMENTAL NEUROLOGY

Hippocampal administration of chondroitinase ABC increases plaque-adjacent synaptic marker and diminishes amyloid burden in aged APPswe/PS1dE9 mice

(2015) Matthew D. Howell et al.   Acta Neuropathologica Communications

Inhibitory Act of Selenoprotein P on Cu+/Cu2+-Induced Tau Aggregation and Neurotoxicity

(2014) Xiubo Du et al.   INORGANIC CHEMISTRY

Effect of taxoid and nontaxoid site microtubule-stabilizing agents on axonal transport of mitochondria in untransfected and ECFP-htau40-transfected rat cortical neurons in culture

(2014) Viswanath Das et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neuronal transport defects of the MAP6 KO mouse – a model of schizophrenia – and alleviation by Epothilone D treatment, as observed using MEMRI

(2014) Alexia Daoust et al.   NEUROIMAGE

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

(2013) A.R. Esteves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Persistence of amygdala gamma oscillations during extinction learning predicts spontaneous fear recovery

(2013) J. Courtin et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neurochemical mapping of the human hippocampus reveals perisynaptic matrix around functional synapses in Alzheimer’s disease

(2012) Dávid Lendvai et al.   ACTA NEUROPATHOLOGICA

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies: Figure 1

(2012) Kurt R. Brunden et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?

(2012) C. La Morgia et al.   EUROPEAN JOURNAL OF NEUROLOGY

Both chronic treatments by epothilone D and fluoxetine increase the short-term memory and differentially alter the mood status of STOP/MAP6 KO mice

(2012) Vincent Fournet et al.   JOURNAL OF NEUROCHEMISTRY

Hyperdynamic Microtubules, Cognitive Deficits, and Pathology Are Improved in Tau Transgenic Mice with Low Doses of the Microtubule-Stabilizing Agent BMS-241027

(2012) D. M. Barten et al.   JOURNAL OF NEUROSCIENCE

The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

(2012) B. Zhang et al.   JOURNAL OF NEUROSCIENCE

Amyloid beta impairs mitochondrial anterograde transport and degenerates synapses in Alzheimer's disease neurons

(2011) Marcus J. Calkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Extracellular matrix and perineuronal nets in CNS repair

(2011) Jessica C.F. Kwok et al.   Developmental Neurobiology

How Inhibition Shapes Cortical Activity

(2011) Jeffry S. Isaacson et al.   NEURON

From brain formation to plasticity: Insights on Otx2 homeoprotein

(2010) Sayaka Sugiyama et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Epothilone D Improves Microtubule Density, Axonal Integrity, and Cognition in a Transgenic Mouse Model of Tauopathy

(2010) K. R. Brunden et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons

(2010) Xinglong Wang et al.   Neurodegenerative Diseases

Changes in microtubule turnover accompany synaptic plasticity and memory formation in response to contextual fear conditioning in mice

(2010) P. Fanara et al.   NEUROSCIENCE

NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse—A microtubule-deficient model of schizophrenia

(2010) Avia Merenlender-Wagner et al.   PEPTIDES

Perineuronal Nets Protect Fear Memories from Erasure

(2009) N. Gogolla et al.   SCIENCE

A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer's Disease

(2008) Y. Matsuoka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Faster forgetting contributes to impaired spatial memory in the PDAPP mouse: Deficit in memory retrieval associated with increased sensitivity to interference?

(2008) S. Daumas et al.   LEARNING & MEMORY