Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture

A Probabilistic Classification Tool for Genetic Subtypes of Diffuse Large B Cell Lymphoma with Therapeutic Implications

(2020) George W. Wright et al.   CANCER CELL

H1 histones control the epigenetic landscape by local chromatin compaction

(2020) Michael A. Willcockson et al.   NATURE

Mesoscale modeling reveals formation of an epigenetically driven HOXC gene hub

(2019) Gavin D. Bascom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The expanding landscape of ‘oncohistone’ mutations in human cancers

(2019) Benjamin A. Nacev et al.   NATURE

A Mutation in Histone H2B Represents a New Class of Oncogenic Driver

(2019) Richard L Bennett et al.   Cancer Discovery

Targeting the Immune Microenvironment in Lymphomas of B-Cell Origin: From Biology to Clinical Application

(2019) Mulder et al.   Cancers

NSD2 overexpression drives clustered chromatin and transcriptional changes in a subset of insulated domains

(2019) Priscillia Lhoumaud et al.   Nature Communications

Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming

(2018) Ralph Stadhouders et al.   NATURE GENETICS

Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes

(2018) Bjoern Chapuy et al.   NATURE MEDICINE

Principles of Chromosome Architecture Revealed by Hi-C

(2018) Kyle P. Eagen   TRENDS IN BIOCHEMICAL SCIENCES

An activating mutation of the NSD2 histone methyltransferase drives oncogenic reprogramming in acute lymphocytic leukemia

(2018) Alok Swaroop et al.   ONCOGENE

Emerging roles of linker histones in regulating chromatin structure and function

(2017) Dmitry V. Fyodorov et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Germinal Center B Cell Dynamics

(2016) Luka Mesin et al.   IMMUNITY

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape

(2016) C. Lu et al.   SCIENCE

Structural Mechanisms of Nucleosome Recognition by Linker Histones

(2015) Bing-Rui Zhou et al.   MOLECULAR CELL

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development

(2015) Ana Ortega-Molina et al.   NATURE MEDICINE

Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3

(2015) Jin-Man Kim et al.   Scientific Reports

Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma

(2014) H. Li et al.   BLOOD

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells

(2014) J. Reichel et al.   BLOOD

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation

(2013) Wendy Béguelin et al.   CANCER CELL

Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphoma

(2013) Jessica Okosun et al.   NATURE GENETICS

H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation

(2013) S.-M. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Genomic Landscape of the Somatic Linker Histone Subtypes H1.1 to H1.5 in Human Cells

(2013) Annalisa Izzo et al.   Cell Reports

High-Resolution Mapping of H1 Linker Histone Variants in Embryonic Stem Cells

(2013) Kaixiang Cao et al.   PLoS Genetics

The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial–mesenchymal transition and invasive properties of prostate cancer

(2012) T Ezponda et al.   ONCOGENE

Histone H1 Depletion Impairs Embryonic Stem Cell Differentiation

(2012) Yunzhe Zhang et al.   PLoS Genetics

Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells

(2009) Sarah Eminli et al.   NATURE GENETICS

Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells

(2008) David J. Wong et al.   Cell Stem Cell