期刊
NANO LETTERS
卷 21, 期 2, 页码 1124-1131出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.nanolett.0c04578
关键词
Gold nanoparticles; Antibacterial; Oral administration; In vivo synthesis; Biosafety
类别
资金
- Shenzhen Science and Technology Program [KQTD20190929172743294]
- National Natural Science Foundation of China [21535001, 81730051, 81673039, 32071390]
- National Key R&D Program of China [2018YFA0902600]
- Chinese Academy of Sciences [QYZDJ-SSW-SLH039, 121D11KYSB20170026]
- Shenzhen Bay Laboratory [SZBL2019062801004]
- Guangdong Innovative and Entrepreneurial Research Team Program [2019ZT08Y191]
- Tencent Foundation through the XPLORER PRIZE
Oral administration of two starting materials can robustly synthesize gold nanoparticles in vivo, which exhibit excellent antibacterial efficacy against multidrug resistant bacteria, long half-life, and high biosafety.
Oral administration is a facile and safe way for medication. However, most of the reported nanomedicines could not be taken orally, partially due to their unsatisfied stability, poor absorbance, or toxicity in the gastrointestinal tract. Here, we demonstrate that we could robustly synthesize gold nanoparticles (GNPs) in vivo by orally administering two starting materials, tetrachloroauric acid and aminophenyl boronic acid (ABA). The ABA-activated GNPs (A-GNPs) synthesized in vivo could be absorbed by the gastrointestinal tract and reach the remote infection lesions such as peritonitis caused by multidrug resistant (MDR) bacteria in mice. The A-GNPs exhibit excellent antibacterial efficacy (MIC, 3 mu g/mL), long half-life (16-17 h), effective clearance (residual concentration is near 0 within 72 h), and high biosafety (safe dose/effective dose, 8 times). Our study is a pioneering attempt for synthesizing and taking nanomedicines orally just like preparing and drinking a cocktail.
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