Article
Microbiology
Maria Laura Breser, Lucia Tisera, Maria Soledad Orellano, Luciana Paola Bohl, Paula Isaac, Ismael Bianco, Carina Porporatto
Summary: Bovine mastitis, a common and costly disease in dairy cattle, is often caused by non-aureus staphylococci (NAS) which have strong biofilm biomass. The intensity of biofilm biomass is associated with antibiotic resistance, and chitosan (Ch) shows potential to counteract the biofilm protection. This research suggests considering bacterial biomass when designing new antimicrobial therapies to improve cure rates by reducing antibiotic concentrations.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Physical
Xufeng Zhu, Xu Chen, Zhi Jia, Dongliang Huo, Yanan Liu, Jie Liu
Summary: By constructing a nanozyme with antibacterial activity, the research successfully disrupted bacterial biofilms and demonstrated its therapeutic efficacy in rescuing skin wound infections and chronic lung infections in mice.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Environmental Sciences
Jinxin Liu, Feng Yu, Douglas R. Call, David A. Mills, Anyun Zhang, Zhe Zhao
Summary: Exposure to antibiotic-treated animals had a direct impact on the soil microbiome and resistome, leading to significant increases in antimicrobial resistance genes (ARGs) in the exposed soil. Evaluating on-farm effects to soil after exposure to antibiotic-treated animals can help in designing effective management strategies to mitigate antibiotic resistance in food-animal production.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Infectious Diseases
Edet E. Udo, Samar S. Boswihi, Bindu Mathew, Bobby Noronha, Tina Verghese
Summary: This study investigated the genotypes and antibiotic resistance of chloramphenicol-resistant MRSA isolates in Kuwait hospitals and found that the resurgence of chloramphenicol resistance was due to the introduction and spread of closely related fexA-positive CC5-ST5-V and CC5-ST627-VI clones.
Article
Chemistry, Applied
Ruilian Li, Limeng Zhu, Dongdong Liu, Wenjing Wang, Chen Zhang, Siming Jiao, Jinhua Wei, Lishi Ren, Yuchen Zhang, Xun Gou, Xianghua Yuan, Yuguang Du, Zhuo A. Wang
Summary: The study demonstrated that a cell wall polymer analog, HCOS, showed apparent antifungal activity against Candida strains, especially those in biofilm. Mechanistic studies suggested that HCOS exerts its activity by interfering with the connection and assembly of cell wall polysaccharides.
CARBOHYDRATE POLYMERS
(2022)
Article
Environmental Sciences
Yangcheng Ding, Jinglong Han, Huajun Feng, Yuxiang Liang, Wenli Jiang, Shuhao Liu, Bin Liang, Meizhen Wang, Zhiling Li, Aijie Wang, Nanqi Ren
Summary: The study demonstrated that advanced reduction process with UV/sulfite system can effectively degrade halogenated antibiotics like florfenicol, preventing the proliferation and transmission of related antibiotic resistance genes in the subsequent biotreatment process.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Infectious Diseases
Weidong Qian, Xinchen Li, Min Yang, Chanchan Liu, Yi Kong, Yongdong Li, Ting Wang, Qian Zhang
Summary: This study investigated the association between biofilm formation and antibiotic resistance in extensively drug-resistant Escherichia coli isolates. The results showed that stronger biofilm formation was correlated with larger proportions of extensively drug-resistant isolates. These findings provide novel insights for the prevention and treatment of E. coli-related infections.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Weidong Qian, Xinchen Li, Min Yang, Chanchan Liu, Yi Kong, Yongdong Li, Ting Wang, Qian Zhang
Summary: This study evaluated the antibiotic resistance/susceptibility profiles and biofilm-forming capacities of 81 Escherichia coli isolates from pediatric individuals in China, revealing an association between biofilm formation and resistance to several antibiotics for extensively drug-resistant strains. This finding provides novel insights for the prevention and treatment against E. coli-related infections.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Microbiology
Stephen J. Kassinger, Monique L. van Hoek
Summary: Tularemia caused by Francisella tularensis has been historically developed into a biological weapon. In order to optimize patient treatment and potentially develop new antimicrobials, understanding the genetically encoded determinants of antibiotic resistance in Francisella is crucial. Research has been conducted on both the experimental and bioinformatic aspects of antibiotic resistance in Francisella, as well as the difference in phenotypic resistance between planktonic and biofilm forms of the bacteria.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Fisheries
Cristian Oliver, Constanza Cespedes, Natacha Santibanez, Pamela Ruiz, Alex Romero
Summary: Improper use of antibiotics in the Chilean aquaculture industry leads to the generation of multidrug resistance bacteria, which form biofilms and serve as reservoirs of pathogens in the marine environment.
JOURNAL OF FISH DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Natalia Kazmierczak, Bartlomiej Grygorcewicz, Marta Roszak, Beata Bochentyn, Lidia Piechowicz
Summary: The investigation and development of novel treatment strategies are necessary to address problems related to biofilm-related infections and antibiotic resistance. Bacteriophages, as promising alternatives to conventional antibiotics, have been shown to be effective antibiofilm agents in both in vitro and in vivo larva model studies. The results demonstrate that phages vB_SauM-A, vB_SauM-C, and vB_SauM-D can effectively reduce the colony-forming unit number of multidrug-resistant S. aureus strains in biofilms, independently of the phage titer used. Furthermore, bacteriophages were found to be more efficient than antibiotics in removing biofilm biomass and reducing staphylococci count. Additionally, phages vB_SauM-A, vB_SauM-C, and vB_SauM-D can enhance the survival rate and prolong the survival time of Galleria mellonella larvae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Infectious Diseases
Maria Baltogianni, Vasileios Giapros, Chrysoula Kosmeri
Summary: Neonatal sepsis is a major cause of morbidity and mortality in newborns. Antibiotic resistance is a significant issue in neonatal intensive care units, and biofilm infections also pose challenges. This review aims to discuss various approaches to combat antibiotic-resistant bacteria and biofilm infections in NICUs.
Article
Infectious Diseases
Robin Fruh, Annette Anderson, Fabian Cieplik, Elmar Hellwig, Annette Wittmer, Kirstin Vach, Ali Al-Ahmad
Summary: This study investigated the adaptation of oral bacteria to the oral antiseptic CHX and its potential cross-adaptation to antibiotics. The results showed that repeated exposure to subinhibitory concentrations of CHX led to increased resistance to CHX and certain antibiotics, while decreasing biofilm-forming capacity.
Review
Environmental Sciences
Sahar Gholipour, Zahra Shamsizadeh, Willis Gwenzi, Mahnaz Nikaeen
Summary: This systematic review investigates the occurrence, behavior, fate, and detection methods of bacterial biofilm resistome in drinking water distribution systems. Antibiotic resistant bacteria and genes were found in biofilms, including those for sulfonamides, tetracycline, and beta-lactamase. The presence of certain bacteria indicates potential human health risks through drinking water consumption. The effects of water quality parameters and residual chlorine, as well as the controlling factors of the biofilm resistome, are still poorly understood.
Article
Microbiology
Yayu Xiao, Peiyu Zhang, Huan Zhang, Huan Wang, Guo Min, Hongxia Wang, Yuyu Wang, Jun Xu
Summary: Widespread and inappropriate use of antibiotics increases the spread of antibiotics and antimicrobial resistance genes in aquatic environments and organisms. The growth response of Bellamya aeruginosa to florfenicol was tested under different concentrations of sediment organic matter. The study found that high organic matter content in sediment impacted the growth, intestinal bacterial community, antimicrobial resistance genes, and metabolic pathways of B. aeruginosa.
Article
Biochemistry & Molecular Biology
Ezekiel J. Maier, Brian C. Haynes, Stacey R. Gish, Zhuo A. Wang, Michael L. Skowyra, Alyssa L. Marulli, Tamara L. Doering, Michael R. Brent
Article
Chemistry, Analytical
Rui Mao, Lifei Qi, Jianjun Li, Ming Sun, Zhuo Wang, Yuguang Du
Article
Chemistry, Medicinal
Guiqiang Zhang, Jing Liu, Ruilian Li, Siming Jiao, Cui Feng, Zhuo A. Wang, Yuguang Du
Article
Chemistry, Multidisciplinary
Rui Mao, Lifei Qi, Zhuo Wang, Hongtao Liu, Yuguang Du
Article
Multidisciplinary Sciences
Jinhua Wei, Zhuo A. Wang, Bing Wang, Marefa Jahan, Zhongfu Wang, Peter C. Wynn, Yuguang Du
SCIENTIFIC REPORTS
(2018)
Article
Microbiology
Zhuo A. Wang, Cara L. Griffith, Michael L. Skowyra, Nichole Salinas, Matthew Williams, Ezekiel J. Maier, Stacey R. Gish, Hong Liu, Michael R. Brent, Tamara L. Doering
Article
Chemistry, Medicinal
Ruilian Li, Xianghua Yuan, Jinhua Wei, Xiafei Zhang, Gong Cheng, Zhuo A. Wang, Yuguang Du
Article
Microbiology
Chen Zhang, Siming Jiao, Zhuo A. Wang, Yuguang Du
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Chemistry, Medicinal
Bolin Jing, Gong Cheng, Jianjun Li, Zhuo A. Wang, Yuguang Du
Article
Chemistry, Medicinal
Limeng Zhu, Ruilian Li, Siming Jiao, Jinhua Wei, Yalu Yan, Zhuo A. Wang, Jianjun Li, Yuguang Du
Article
Biochemistry & Molecular Biology
Yujie Wang, Rong Wen, Dongdong Liu, Chen Zhang, Zhuo A. Wang, Yuguang Du
Summary: Chitosan oligosaccharide has been shown to have a protective effect on intestinal mucus in inflammatory bowel disease, improving DSS-induced mucus defects, with its structural characteristics playing a key role in this activity.
Review
Biochemistry & Molecular Biology
Tong Xu, Ruijie Sun, Yuchen Zhang, Chen Zhang, Yujing Wang, Zhuo A. Wang, Yuguang Du
Summary: Functional oligosaccharides can repair damaged intestines and have positive effects on intestinal health by regulating intestinal barrier function, immune response, and intestinal microbial composition.