Review
Medicine, Research & Experimental
Rong Dong, Bo Zhang, Biqin Tan, Nengming Lin
Summary: Macrophages play a crucial role in M2 polarization, which is regulated by various factors. Long non-coding RNAs (lncRNAs) are essential for the process, guiding macrophages towards an M2 phenotype through multiple mechanisms. Exosomal lncRNAs can also regulate polarization through paracrine action.
Review
Oncology
Mohammad Roshani, Ghazaleh Baniebrahimi, Mahboubeh Mousavi, Noushid Zare, Reza Sadeghi, Reza Salarinia, Amirhossein Sheida, Danial Molavizadeh, Sara Sadeghi, Farzaneh Moammer, Mohammad Reza Zolfaghari, Hamed Mirzaei
Summary: Exosomal lncRNAs play a crucial role in the biology of gastrointestinal cancer and can be utilized as biomarkers for diagnosis, prognosis, and potential treatment targets.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniele Lettieri-Barbato, Katia Aquilano, Carolina Punziano, Giuseppina Minopoli, Raffaella Faraonio
Summary: Cell senescence plays critical roles in various aspects of organism life, including tissue development, homeostasis, tumor suppression, and aging-related diseases. Oxidative stress, caused by inadequate detoxification of reactive oxygen/nitrogen species, is a major driver of senescence. Non-coding RNAs, such as microRNAs, long non-coding RNAs, and circular RNAs, are important regulators of cellular processes, including oxidative stress responses and senescence.
Review
Cell Biology
Lina Ma, Zhang Zhang
Summary: This comment provides an overview of the types and features of lncRNA databases worldwide, and discusses their contribution to lncRNA research.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Yuchan Yuan, Ling Xu, Zhaohong Geng, Jingjing Liu, Lijiao Zhang, Yuhang Wu, Dan He, Peng Qu
Summary: Atherosclerosis is the primary culprit of cardiovascular and cerebrovascular diseases, and non-coding RNA plays a regulatory role in the development and progression of atherosclerosis.
Review
Medicine, General & Internal
Yachen Shi, Qingyun Wang, Ruize Song, Yan Kong, Zhijun Zhang
Summary: Non-coding RNAs, such as microRNAs, circular RNAs, and long non-coding RNAs, play important roles in regulating normal biological processes and may be implicated in the pathogenesis of human diseases like depression. Clinical studies have shown that abnormal expression of ncRNAs in depressed patients compared to healthy individuals, with potential for ncRNAs to serve as biomarkers for diagnosis and treatment. Despite uncertainties regarding their precise roles, ncRNAs demonstrate promising clinical value in the management of depression.
Review
Biochemistry & Molecular Biology
Ania Canseco-Rodriguez, Valeria Masola, Vincenza Aliperti, Maria Meseguer-Beltran, Aldo Donizetti, Ana Maria Sanchez-Perez
Summary: Neuroinflammation plays a major role in the onset of Alzheimer's Disease (AD), and it exerts its toxic effect through regulation of non-coding RNAs such as miRNAs. Although the association between miRNAs and inflammation in AD has been studied, the role of long non-coding RNAs (lncRNAs) in neurodegenerative diseases is less explored. Recent studies have shown that specific lncRNAs in plasma-isolated extracellular vesicles (EVs) may serve as reliable biomarkers for AD, which holds promise for improving risk prediction and patient stratification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Plant Sciences
K. Bharathan Sruthi, Athira Menon, P. Akash, Eppurath Soniya
Summary: Long non-coding RNAs (lncRNAs) are RNA transcripts longer than 200 nucleotides without coding potential. Recent research shows that lncRNAs can code for micropeptides, which are generated from small open reading frames (smORFs) and found in short mRNAs and non-coding RNAs. Although micropeptides play critical roles in plant development and stress, only a few functions have been verified so far.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Junaid Zafar, Junlin Huang, Xiaoxia Xu, Fengliang Jin
Summary: Over the last decade, there has been a growing interest in long non-coding RNAs (lncRNAs) among scientists. LncRNAs play important roles in various biological processes, and have greatly expanded our understanding of RNA's regulatory potential. However, our knowledge of lncRNAs in insects is limited compared to mammals. This article reviews experimentally validated lncRNAs in insects, as well as lncRNAs identified through bioinformatic tools, and discusses the challenges and future prospects of studying lncRNAs in insects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Massimiliano Agostini, Mara Mancini, Eleonora Candi
Summary: Metabolic reprogramming is a hallmark of cancers and long non-coding RNAs play a role in regulating cancer-specific metabolic alterations. This overview focuses on breast cancer metabolic reprogramming and the involvement of long non-coding RNAs in driving these alterations.
Article
Biochemistry & Molecular Biology
Christopher G. Fenton, Mithlesh Kumar Ray, Wei Meng, Ruth H. Paulssen
Summary: Long non-coding RNAs (lncRNAs) have been found to be involved in the development of ulcerative colitis (UC), and their interplay with DNA methylation and the role of environmental factors in disease development remain to be fully explored. This study analyzed mucosal biopsies from UC patients and normal controls to identify UC-associated lncRNAs regulated by differentially methylated regions (DMRs). The study also identified genes involved in inflammatory immune responses downstream of DMR-regulated lncRNAs. Understanding the interplay between lncRNA expression and DNA methylation in UC could enhance our knowledge of its pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Xin Yu, Xueqing Zhu, Hongjun Xu, Linfeng Li
Summary: Keloids are pathological wound healing conditions that significantly impact patients by causing psychosocial and functional distress. The main pathophysiology of keloid is the deposition of extracellular matrix (ECM) and proliferation of human fibroblasts. Recent research has shown that deregulated long non-coding RNAs (LncRNAs) contribute to the formation of keloids. Exploring lncRNA-based methods holds promise as new effective therapies against keloids.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Praneeth R. Kuninty, Karin Binnemars-Postma, Ahmed Jarray, Kunal P. Pednekar, Marcel A. Heinrich, Helen J. Pijffers, Hetty ten Hoopen, Gert Storm, Peter van Hoogevest, Wouter K. den Otter, Jai Prakash
Summary: In this study, engineered nanoliposomes mimic peroxidated phospholipids and specifically target tumor-associated macrophages. The nanoliposomes are efficiently taken up by M2 macrophages and can reduce premetastatic niche or tumor growth in vivo upon treatment with inhibitors or drugs.
NATURE COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Mirjana T. Macvanin, Zoran Gluvic, Jelena Radovanovic, Magbubah Essack, Xin Gao, Esma R. Isenovic
Summary: Diabetic cardiomyopathy (DCMP) is a leading cause of morbidity and mortality in diabetic patients, and non-coding RNAs such as miRNAs and lncRNAs have been found to play a protective role in regulating processes related to DCMP. This paper reviews the literature on the roles of miRNAs and lncRNAs in DCMP in diabetes and demonstrates their potential for future DCMP treatment in diabetic patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Cinzia Aurilia, Simone Donati, Gaia Palmini, Francesca Miglietta, Irene Falsetti, Teresa Iantomasi, Maria Luisa Brandi
Summary: Tumors of the parathyroid glands are common endocrine diseases characterized by parathyroid hormone hypersecretion, with a wide range of clinical presentations and typically treated through surgical removal. Recent studies have suggested that alterations to the epigenetic mechanisms could play a pivotal role in tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Juhee Ryu, Youngkeun Ahn, Hyun Kook, Young-Kook Kim
Summary: This article reviews the role and therapeutic implications of non-coding RNAs (ncRNAs) in vascular calcification (VC). Studies suggest that ncRNAs, including miRNAs, lncRNAs, and circRNAs, play important roles in regulating VC and may be useful in clinical diagnosis and treatment.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, Research & Experimental
Liyan Bai, Hae Jin Kee, Sin Young Choi, Young Mi Seok, Gwi Ran Kim, Seung-Jung Kee, Hyun Kook, Myung Ho Jeong
Summary: The genetic deletion of HDAC5 and treatment with class IIa HDAC inhibitors can prevent increases in blood pressure and arterial wall thickness induced by Ang II. HDAC5 plays a role in vascular contraction and hypertrophy, and its inhibition may be a potential target for hypertension treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Somy Yoon, Mira Kim, Hangyeol Lee, Gaeun Kang, Kenneth Bedi, Kenneth B. Margulies, Rajan Jain, Kwang-Il Nam, Hyun Kook, Gwang Hyeon Eom
Summary: The study reveals that neuronal nitric oxide synthase induces diastolic dysfunction by S-nitrosylation of HDAC2, suggesting a new therapeutic platform for refractory heart failure with preserved ejection fraction.
Review
Neurosciences
Juhyun Song, Young-Kook Kim
Summary: Depressive disorder is a common psychiatric pathology worldwide, with increasing numbers of patients each year according to a report by the World Health Organization. Research has shown that the risk of depression is influenced by various factors including genetics and environmental stress. Understanding the pathogenesis of depressive disorder is crucial for identifying mechanisms and genetic disorders underlying depression.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Duk-Hwa Kwon, Joo-Young Kang, Hosouk Joung, Ji-Young Kim, Anna Jeong, Hyun-Ki Min, Sera Shin, Yun-Gyeong Lee, Young-Kook Kim, Sang-Beom Seo, Hyun Kook
Summary: The balance between KDM2B and SET7, two competing enzymes that respectively inhibit and activate the same gene-regulating protein SRF, plays a critical role in skeletal muscle cell differentiation. KDM2B inhibits cell differentiation by demethylating SRF, while SET7 activates differentiation by methylating SRF. This study reveals SRF as a novel target of KDM2B and provides insights into skeletal muscle development in health and disease.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Medicine, Research & Experimental
Juhyun Song, Young-Kook Kim
Summary: Maintaining visual function is crucial for longevity, but the number of patients with retinal diseases is not decreasing due to the aging population and technological advances. Surgical intervention remains the primary treatment option for retinal diseases, despite associated complications and side effects. The pathogenesis of these diseases is still not fully understood, hindering drug discovery, leading to increased focus on studying the underlying mechanisms and potential therapeutic targets like non-coding RNAs.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Jung Ha Kim, Kabsun Kim, Inyoung Kim, Semun Seong, Hyun Kook, Kyung Keun Kim, Jeong-Tae Koh, Nacksung Kim
Summary: CrkL regulates the coupling signals between osteoblasts and osteoclasts by decreasing RANKL expression, which plays a crucial role in bone homeostasis by inhibiting both osteoblast-dependent osteoclast differentiation and osteoclast-dependent osteoblast differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yongwoon Lim, Anna Jeong, Duk-Hwa Kwon, Yeong-Un Lee, Young-Kook Kim, Youngkeun Ahn, Taewon Kook, Woo-Jin Park, Hyun Kook
Summary: Various heart diseases lead to ineffective cardiac contraction, with cardiac fibrosis being a contributing factor. PCAF plays a key role in the activation of cardiac fibroblasts during cardiac remodeling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sukjun Kim, Soyoung Kim, Hee Ryung Chang, Doyeon Kim, Junehee Park, Narae Son, Joori Park, Minhyuk Yoon, Gwangung Chae, Young-Kook Kim, V. Narry Kim, Yoon Ki Kim, Jin-Wu Nam, Chanseok Shin, Daehyun Baek
Summary: The study uncovers the significant role of human RBPs in miRNA targeting, with most RBPs acting as enhancers rather than suppressors of MT. This finding expands the understanding of miRNA targeting and emphasizes the importance of considering MT within the context of co-regulating RBPs.
NATURE COMMUNICATIONS
(2021)
Review
Medicine, General & Internal
Young-Kook Kim, Juhyun Song
Summary: Hepatic encephalopathy is a common complication in patients with liver cirrhosis, involving various pathogeneses such as ammonia-induced oxidative stress and neuronal cell death. Researchers are exploring the effects of resveratrol on neuropathogenesis and the gut-liver axis to potentially improve the treatment of hepatic encephalopathy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Danbi Jo, Hee Kyung Kim, Young-Kook Kim, Juhyun Song
Summary: Thyroid hormone plays an important role in liver metabolism, and its levels are disrupted in liver failure and hepatic encephalopathy. This study investigates the gene expression changes in the thyroid glands of a bile duct ligation mouse model and confirms the alteration in thyroid function-related genes. Increased levels of free T4 and TSH are also observed in the blood of the mouse model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Young-Kook Kim, Yoon Seok Jung, Juhyun Song
Summary: Hepatic encephalopathy (HE) is a chronic metabolic disease with neurological and psychiatric symptoms, and recent studies suggest a positive correlation with Alzheimer's disease (AD). Our study compares the gene expression in an HE mouse model and an AD mouse model, revealing a potential link between HE-associated genes and neuronal dysfunction in AD mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Danbi Jo, Gwangho Yoon, Yeonghwan Lim, Youngkook Kim, Juhyun Song
Summary: Recent evidence suggests that neurodegenerative diseases, such as Alzheimer's disease, are associated with metabolic disorders like diabetes and obesity. Studies have shown that circular RNAs (circRNAs) are involved in neuropathological mechanisms in the brain, but their role in metabolic imbalance-related neuropathology has not been explored. In this study, researchers profiled and analyzed circRNAs in mouse brain cell lines exposed to obesity-related conditions and found that these circRNAs regulate genes related to inflammatory responses and fatty acid metabolism, which may contribute to the development of neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)