Functional crosstalk between Long non-coding RNAs and the NLRP3 inflammasome in the regulation of diseases

Emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in various pathophysiological processes of disease, such as cancer occurrence, viral invasion, and inflammatory damage. The main inflammatory body component, nod-like receptor protein 3 (NLRP3), is the trigger point of inflammatory reactions and inflammation-related diseases and coordinates the body's response to inflammation. At present, increasing evidence shows that the interaction of lncRNAs and the NLRP3 inflammasome plays an important role in the inflammatory response and different diseases. This may be involved in the development and progression of various diseases by activating signalling pathways and a variety of molecular regulatory mechanisms-this article reviews progress in research on the relationship between lncRNAs and the NLRP3 inflammasome under different conditions.

Automated summary

The interaction between long noncoding RNAs (lncRNAs) and the NLRP3 inflammasome plays a significant role in inflammatory responses and various diseases, potentially involved in the development and progression of diseases by activating signaling pathways and multiple molecular regulatory mechanisms.