期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111434
关键词
Rheumatoid arthritis; Gold nanoparticles; Tocilizumab; Polydopamine; Oxide free radical
资金
- Natural Science Foundation of China [81571829]
- Fundamental Research Funds for the Central Universities [lzujbky-2020-it29]
- State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences [LSL-1907]
- Medical Subject Fund of Stomatology College of Lanzhou University [lzukqky-2019-t08]
A novel anti-rheumatoid arthritis composite was developed using gold nanoparticles and polydopamine nanoparticles as drug carriers, showing excellent abilities to scavenge oxygen free radicals and inhibit inflammatory factors. The composite had good biocompatibility and promoted the growth of chondrocytes and fibroblasts, indicating potential application in the treatment of RA related diseases.
Rheumatoid arthritis (RA) is the most common chronic autoimmune disorder associated with high-cost, side effects, and low therapeutic effects. To improve the treatment of RA, we originally developed a novel anti-RA Au@polydopamine nanoparticles (PDANPs)/TCZ composite using PDANPs as the binding sites of gold nanoparticles (AuNPs) and the drug carries of tocilizumab (TCZ) through a facile and environmentally-friend method, aiming to effectively scavenge oxygen free radicals (OFR) and inhibit the formation of related inflammatory factors. Characterizations showed that AuNPs with the size of 11.4 +/- 2.9 nm randomly distributed onto the surface of PDANPs (145.8 +/- 31.9 nm), meanwhile TCZ was chemically cross-linked to PDANPs through Schiff base linkage. The synthesized composite had good biocompatibility that can promote the proliferation and growth of chondrocytes and fibroblasts. More importantly, Au@PDANPs/TCZ composite showed more excellent abilities to scavenge OFR and inhibit the related inflammatory factors in vitro and in vivo than that of AuNPs and PDANPs owing to the synergistic scavenging effect, ensuring its best therapeutic effect in RA therapy. This new composite will have application potential in the treatment of RA related disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据