Initiation of PI3K/AKT pathway by IGF-1 decreases spinal cord injury-induced endothelial apoptosis and microvascular damage

Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway

(2020) Zhanyang Qian et al.   BRAIN BEHAVIOR AND IMMUNITY

IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway

(2020) Mingzhuo Lin et al.   Stem Cell Research & Therapy

Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells

(2020) Justyna Janowska et al.   MOLECULAR NEUROBIOLOGY

Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity

(2020) Weiwei Shi et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Plasma cyclic glycine proline/IGF-1 ratio predicts clinical outcome and recovery in stroke patients

(2019) Dawei Fan et al.   Annals of Clinical and Translational Neurology

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

Effects of IGF‐1 isoforms on muscle growth and sarcopenia

(2019) Francesca Ascenzi et al.   AGING CELL

IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury

(2019) Kyan James Allahdadi et al.   Stem Cell Research & Therapy

The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells

(2018) Tian Shuang et al.   BIOCHEMICAL PHARMACOLOGY

Therapeutic Effect of Platelet-Rich Plasma in Rat Spinal Cord Injuries

(2018) Nan-Fu Chen et al.   Frontiers in Neuroscience

Neuromodulation in the restoration of function after spinal cord injury

(2018) Nicholas D James et al.   LANCET NEUROLOGY

Neutrophil elastase inhibition effectively rescued angiopoietin-1 decrease and inhibits glial scar after spinal cord injury

(2018) Hemant Kumar et al.   Acta Neuropathologica Communications

miR-21 and miR-19b delivered by hMSC-derived EVs regulate the apoptosis and differentiation of neurons in patients with spinal cord injury

(2018) Guanghui Xu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) Spencer L James et al.   LANCET NEUROLOGY

IGF-1 and somatocrinin trigger islet differentiation in human amniotic membrane derived mesenchymal stem cells

(2018) Avinash Kharat et al.   LIFE SCIENCES

Matrix Metalloproteinase-8 Inhibition Prevents Disruption of Blood–Spinal Cord Barrier and Attenuates Inflammation in Rat Model of Spinal Cord Injury

(2017) Hemant Kumar et al.   MOLECULAR NEUROBIOLOGY

The diversity and disparity of the glial scar

(2017) Katrina L. Adams et al.   NATURE NEUROSCIENCE

Serum Insulin-Like Growth Factor 1 and the Risk of Ischemic Stroke

(2017) Hamidreza Saber et al.   STROKE

Traumatic spinal cord injury

(2017) Christopher S. Ahuja et al.   Nature Reviews Disease Primers

miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis

(2016) Xintong Ge et al.   BRAIN RESEARCH

Insulin-like growth factor 1 rescues R28 retinal neurons from apoptotic death through ERK-mediated BimEL phosphorylation independent of Akt

(2016) Dejuan Kong et al.   EXPERIMENTAL EYE RESEARCH

The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity

(2016) Adam H. Dyer et al.   NEUROSCIENCE

Insulin-like growth factor-1 attenuates apoptosis and protects neurochemical phenotypes of dorsal root ganglion neurons with paclitaxel-induced neurotoxicity in vitro

(2016) Cheng Chen et al.   NUTRITIONAL NEUROSCIENCE

Elevated Serum Insulin-Like Growth Factor 1 Levels in Patients with Neurological Remission after Traumatic Spinal Cord Injury

(2016) Arash Moghaddam et al.   PLoS One

Nanowired Delivery of Growth Hormone Attenuates Pathophysiology of Spinal Cord Injury and Enhances Insulin-Like Growth Factor-1 Concentration in the Plasma and the Spinal Cord

(2015) Dafin F. Muresanu et al.   MOLECULAR NEUROBIOLOGY

EphB3 receptors function as dependence receptors to mediate oligodendrocyte cell death following contusive spinal cord injury

(2015) Y Tsenkina et al.   Cell Death & Disease

Role and Importance of IGF-1 in Traumatic Brain Injuries

(2015) Annunziato Mangiola et al.   Biomed Research International

Adipose stem cells-conditioned medium blocks 6-hydroxydopamine-induced neurotoxicity via the IGF-1/PI3K/AKT pathway

(2014) Xianjun Wang et al.   NEUROSCIENCE LETTERS

Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: Targets for disease modification?

(2014) Fares Bassil et al.   PROGRESS IN NEUROBIOLOGY

Treadmill exercise reduces spinal cord injury-induced apoptosis by activating the PI3K/Akt pathway in rats

(2013) SUN-YOUNG JUNG et al.   Experimental and Therapeutic Medicine

Molecular and cellular mechanisms underlying the role of blood vessels in spinal cord injury and repair

(2012) Martin Oudega   CELL AND TISSUE RESEARCH

Activation of ERK1/2 and PI3K/Akt by IGF-1 on GAP-43 Expression in DRG Neurons with Excitotoxicity Induced by Glutamate In Vitro

(2011) Zhen Liu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Rescuing vasculature with intravenous angiopoietin-1 and  v 3 integrin peptide is protective after spinal cord injury

(2010) S. Han et al.   BRAIN

Sustained Expression of Vascular Endothelial Growth Factor and Angiopoietin-1 Improves Blood–Spinal Cord Barrier Integrity and Functional Recovery after Spinal Cord Injury

(2010) Juan J. Herrera et al.   JOURNAL OF NEUROTRAUMA

AAV4-mediated Expression of IGF-1 and VEGF Within Cellular Components of the Ventricular System Improves Survival Outcome in Familial ALS Mice

(2010) James C Dodge et al.   MOLECULAR THERAPY

Neuronal Activity Drives Localized Blood-Brain-Barrier Transport of Serum Insulin-like Growth Factor-I into the CNS

(2010) Takeshi Nishijima et al.   NEURON

Limaprost reduces motor disturbances by increasing the production of insulin-like growth factor I in rats subjected to spinal cord injury

(2010) Takehiro Umemura et al.   Translational Research

Two Faces of Chondroitin Sulfate Proteoglycan in Spinal Cord Repair: A Role in Microglia/Macrophage Activation

(2008) Asya Rolls et al.   PLOS MEDICINE