Autophagy blockade mechanistically links proton pump inhibitors to worsened diabetic nephropathy and aborts the renoprotection of metformin/enalapril

Differential Modulation of Autophagy Contributes to the Protective Effects of Resveratrol and Co-enzyme Q10 in Photoaged Mice

(2020) Dalia Kamal Mostafa et al.   Current Molecular Pharmacology

Metformin prevents cell tumorigenesis through autophagy-related cell death

(2019) Mauro De Santi et al.   Scientific Reports

High Dose Vitamin E Attenuates Diabetic Nephropathy via Alleviation of Autophagic Stress

(2019) Yuxue Zhao et al.   Frontiers in Physiology

Proton Pump Inhibitors and Risk of Acute and Chronic Kidney Disease: A Retrospective Cohort Study

(2019) Emily Hart et al.   PHARMACOTHERAPY

The Effect of Proton Pump Inhibitors on Glycemic Control in Patients with Type 2 Diabetes

(2019) Kelly Villegas et al.   Metabolic Syndrome and Related Disorders

Podocytes and autophagy: a potential therapeutic target in lupus nephritis

(2019) Xu-Jie Zhou et al.   Autophagy

The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses

(2018) Yu Cao et al.   Cell Death & Disease

Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients

(2018) Hsun Yang et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Metformin attenuates diabetes-induced tau hyperphosphorylation in vitro and in vivo by enhancing autophagic clearance

(2018) Jin-Liang Chen et al.   EXPERIMENTAL NEUROLOGY

mTORC1 as the main gateway to autophagy

(2017) Yoana Rabanal-Ruiz et al.   Essays in Biochemistry

25 Years of Proton Pump Inhibitors: A Comprehensive Review

(2017) Daniel S. Strand et al.   Gut and Liver

Proton Pump Inhibitors, Nephropathy, and Cardiovascular Disease in Type 2 Diabetes: The Fremantle Diabetes Study

(2017) Timothy M E Davis et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury

(2017) Yan Xie et al.   KIDNEY INTERNATIONAL

Metformin extends C. elegans lifespan through lysosomal pathway

(2017) Jie Chen et al.   eLife

Podocyte Autophagy: A Potential Therapeutic Target to Prevent the Progression of Diabetic Nephropathy

(2017) Na Liu et al.   Journal of Diabetes Research

Transcription factor EB: from master coordinator of lysosomal pathways to candidate therapeutic target in degenerative storage diseases

(2016) Marco Sardiello   Annals of the New York Academy of Sciences

Pleiotropic protective effects of Vitamin D against high fat diet-induced metabolic syndrome in rats: One for all

(2016) Dalia K. Mostafa et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

PPIs and kidney disease: from AIN to CKD

(2016) Dennis G. Moledina et al.   JOURNAL OF NEPHROLOGY

Proton pump inhibitor prescribing patterns in the UK: a primary care database study

(2016) Fatmah Othman et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Proton pump inhibitors are associated with increased risk of development of chronic kidney disease

(2016) Pradeep Arora et al.   BMC Nephrology

Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease

(2016) Benjamin Lazarus et al.   JAMA Internal Medicine

Proton Pump Inhibitors Display Antitumor Effects in Barrett's Adenocarcinoma Cells

(2016) Eduardo Chueca et al.   Frontiers in Pharmacology

Renal biomarkers of male and female Wistar rats (Rattus norvegicus) undergoing renal ischemia and reperfusion

(2015) Telma Bazzano et al.   Acta Cirurgica Brasileira

Mechanisms of Autophagy

(2015) Nobuo N. Noda et al.   Annual Review of Biophysics

Emerging role of podocyte autophagy in the progression of diabetic nephropathy

(2015) Mako Yasuda-Yamahara et al.   Autophagy

Endothelial cell and podocyte autophagy synergistically protect from diabetes-induced glomerulosclerosis

(2015) Olivia Lenoir et al.   Autophagy

Influence of the proton pump inhibitor lansoprazole on distribution and activity of doxorubicin in solid tumors

(2015) Man Yu et al.   CANCER SCIENCE

p62 links autophagy and Nrf2 signaling

(2015) Tao Jiang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy

(2015) Shinji Kume et al.   Diabetes & Metabolism Journal

Multimorbidities and Overprescription of Proton Pump Inhibitors in Older Patients

(2015) Anne Delcher et al.   PLoS One

Autophagy protects renal tubular cells against cyclosporine toxicity

(2014) Nicolas Pallet et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

(2014) Daniel J. Klionsky et al.   Autophagy

Autophagy in diabetic nephropathy

(2014) Yan Ding et al.   JOURNAL OF ENDOCRINOLOGY

Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance-relevant miRNAs in esophageal cancer

(2014) Kirsten Lindner et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Thioredoxin-interacting protein mediates dysfunction of tubular autophagy in diabetic kidneys through inhibiting autophagic flux

(2014) Chunling Huang et al.   LABORATORY INVESTIGATION

The Proton Pump Inhibitor Lansoprazole Improves the Skeletal Phenotype in Dystrophin Deficient mdx Mice

(2013) Arpana Sali et al.   PLoS One

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

(2012)   AMERICAN JOURNAL OF KIDNEY DISEASES

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Intracellular Proton Pumps as Targets in Chemotherapy: V-ATPases and Cancer

(2012) Agustin Hernandez et al.   CURRENT PHARMACEUTICAL DESIGN

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Pathologic Classification of Diabetic Nephropathy

(2010) T. W. C. Tervaert et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway

(2010) Ana I. Morales et al.   KIDNEY INTERNATIONAL

A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62

(2010) A. Lau et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA