Article
Medicine, Research & Experimental
Xia Lv, Xiang-Yan Zhang, Qian Zhang, Ying-Jie Nie, Guang-Heng Luo, Xia Fan, Song Yang, Qing-Hua Zhao, Jian-Quan Li
Summary: The study reveals that NEAT1 plays a role in the inflammation and cell cycle progression of ARDS via the NEAT1/miR-27a/PTEN regulatory network, providing new insight into the pathologic mechanism behind ARDS.
LABORATORY INVESTIGATION
(2021)
Article
Chemistry, Applied
Lujia Zhang, Li Dong, Liuqing Yang, Yinghua Luo, Fang Chen
Summary: Acrylamide, a potential carcinogen formed in high-heat carbohydrate-rich foods, induces mitochondrial dysfunction. The overexpression of miR-27a-5p regulates mitochondrial dysfunction, with Btf3 identified as its target gene. The miR-27a-5p-Btf3-ATM-p53 axis plays a crucial role in promoting AA-induced cell apoptosis by disrupting mitochondrial structure and function.
Article
Agriculture, Multidisciplinary
Shi-Yong Zhu, Xue-Nan Li, Yi Zhao, Xue-Yan Dai, Jian-Ying Guo, Jin-Long Li
Summary: The study found that atrazine induced Foxo1 deficiency in the B cell zone of the spleen, leading to toxicity, while lycopene ameliorated atrazine-induced apoptosis in the B cell zone through regulating the miR-27a-3p/Foxo1 pathway. This research underscores the important role of lycopene in maintaining homeostasis during B cell maturation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Oncology
Rana S. Moubarak, Lisa Koetz-Ploch, Gavriel Mullokandov, Avital Gaziel, Ana De Pablos-Aragoneses, Diana Argibay, Kevin Kleffman, Elena Sokolova, Marianne Berwick, Nancy E. Thomas, Iman Osman, Brian D. Brown, Eva Hernando
Summary: Melanoma is a highly prevalent cancer with high metastatic potential. The study found that miR-124a plays a suppressive role in the metastasis of melanoma, especially in brain metastasis. Overexpression of miR-124a does not inhibit tumor growth but specifically controls the metastatic process of melanoma. miR-124a has the potential to be used as a therapeutic agent to impair melanoma metastatic growth and improve patient survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mengqi Yu, Lanlan Li, Meng Liu, Lei Wang, Xiaoxiao Gao, Lisheng Zhou, Nan Liu, Jianning He
Summary: The quality of wool in agricultural animals is related to the development of hair follicles, which is influenced by hair follicle stem cells (HFSCs) and microRNA miR-27a. This study found that miR-27a inhibits the AKT/MTOR signaling pathway by targeting PIK3R3, thereby affecting the proliferation and apoptosis of HFSCs. These findings provide new insights into improving sheep wool quality.
Article
Biochemistry & Molecular Biology
Yizhen Huang, Zhenlei Zhang, Jianle Wang, Shuying Shen, Teng Yao, Yining Xu, Zizheng Chen, Bin Fang, Jianjun Ma
Summary: The study identified the crucial role of circRNA circSPG21 in regulating IVDD by modulating the balance of anabolic and catabolic factors, influencing cell senescence and alleviating symptoms of the disease. This finding suggests that targeting circSPG21 could potentially serve as an effective therapeutic strategy for IVDD.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xiang-jun Chen, Sha Liu, Dong-mei Han, De-zhi Han, Wei-jing Sun, Xiao-chun Zhao
Summary: RP11-705C15.3 is identified as an oncogene in melanoma, which promotes tumor growth and metastasis by regulating the miR-145-5p/NRAS/MAPK signaling axis, and is positively correlated with the malignancy and overall survival of melanoma patients.
CANCER GENE THERAPY
(2021)
Review
Oncology
Yin-zhao Jia, Jing Liu, Geng-qiao Wang, Zi-fang Song
Summary: Disorders of miR-484 expression are observed in various diseases including cancer, and it is considered a key regulator in these diseases. It targets proteins involved in inflammation, apoptosis, and mitochondrial function. Contrary to previous beliefs, miR-484 not only acts as a tumor suppressor but also promotes tumorigenesis and metastasis in liver, prostate, and lung tissues.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Guiyue Cai, Ruitao Zou, Huizhi Yang, Jiahao Xie, Xiaoxuan Chen, Chunchan Zheng, Sujun Luo, Na Wei, Shuang Liu, Rongyi Chen
Summary: This study investigates the regulatory effect of the circ_0084043-miR-134-5p axis on melanoma and its impact on the expression levels of Pyk2, RAC1, Cyclin D1, MMP2, and MMP9. The results show that PCDH9, regulated by the circ_0084043-miR-134-5p axis, can suppress the malignant behavior of melanoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Xiaoyan Li, Fenglei Gao, Yushan Fan, Shefeng Xie, Chengde Li, Li Meng, Li Li, Shouquan Zhang, Hengxi Wei
Summary: This study identified a novel circRNA, circ-ANKHD1, that may play a role in the biological functions of granulosa cells. Circ-ANKHD1 may promote granulosa cell proliferation and reduce apoptosis, possibly through modulation of miR-27a-3p/SFRP1.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Oncology
Kai-Lee Wang, Ying-Chun Yu, Shih-Min Hsia
Summary: The review provides a summary of the latest research on the metabolites, pharmacokinetics, and pharmacological effects of isoliquiritigenin (ISL) and its derivatives, highlighting the therapeutic molecular targets involved in antitumor effects in different cancers. It also includes a comprehensive account of the applications of ISL in various therapeutic schemes for treating different cancers, either alone or in combination with other drugs.
Article
Biochemistry & Molecular Biology
Xian Shi, Xidan Xu, Nian Shi, Yongjun Chen, Manni Fu
Summary: MiR-767-3p has been found to inhibit the expression of ASF1B, thus reducing melanoma tumorigenesis. This has potential implications for the treatment of melanoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lu Yu, Xiaogang Zhang, Xingchao Liu, Gang Li, Mingliang Chen, Zexin Liu, Qinghe Liu
Summary: This study found that the interaction between circTMOD3 and miR-27a plays an important role in LPS-induced chondrocyte apoptosis in OA. circTMOD3 promotes chondrocyte apoptosis induced by LPS by suppressing miR-27a maturation.
JOURNAL OF BONE AND MINERAL METABOLISM
(2022)
Article
Agriculture, Dairy & Animal Science
Bo Li, Xiaoyu Huang, Chen Yang, Ting Ge, Leiyun Zhao, Xiaoqiang Zhang, Lintao Tian, Enping Zhang
Summary: This study reveals the mechanism by which miR-27a regulates lipid synthesis in sheep through targeting CPT1B, thereby promoting the formation of lipid droplets. These findings are important for improving the nutritional value of sheep meat.
Article
Clinical Neurology
Junjie Li, Lijia Peng, Wenya Bai, Peihua Peng, Wendong Chen, Wei Yang, Jianlin Shao
Summary: The study demonstrated that biliverdin protects against cerebral ischemia/reperfusion injury by regulating the miR-27a-3p/Rgs1 axis to inhibit inflammation and apoptosis.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.
