Article
Pharmacology & Pharmacy
Lei Sun, Man Li, Ling Deng, Yuchun Niu, Yichun Tang, Yu Wang, Linlang Guo
Summary: This study demonstrates that MGA mutation can serve as a novel predictive biomarker for ICI response in non-squamous NSCLC, showing better efficacy and survival outcomes in related patients, associated with higher TMB, neoantigen load, and DNA damage repair deficiency.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Joshua A. Roth, Meghna S. Trivedi, Stacy W. Gray, Donald L. Patrick, Debbie M. Delaney, Kate Watabayashi, Paul Litwin, Parth Shah, Katherine D. Crew, Monica Yee, Mary W. Redman, Joseph M. Unger, Vassiliki Papadimitrakopoulou, Judy Johnson, Karen Kelly, David Gandara, Roy S. Herbst, Dawn L. Hershman, Scott D. Ramsey
Summary: Biomarker-driven master protocols in oncology clinical trials represent a new paradigm, but participants in the study showed incorrect knowledge and expectations regarding the uses of genomic results in the Lung Cancer Master Protocol (Lung-MAP), despite having a reasonable understanding of the benefits and risks associated with the study.
JCO ONCOLOGY PRACTICE
(2021)
Review
Oncology
Prachi Mishra, Dipranjan Laha, Robert Grant, Naris Nilubol
Summary: This article reviews current treatment practices for thyroid cancer and emphasizes on novel targeted molecular therapy. With rapidly expanding knowledge of the molecular biology and increased availability of genetic testing, exciting paradigm shifts in treatment strategies have been observed. Targeted therapies and personalized treatments have become a trend with the development of new treatment strategies, accelerating the advancement of treatments for thyroid cancer.
Article
Oncology
Hossein Borghaei, Mary W. Redman, Karen Kelly, Saima N. Waqar, Francisco Robert, Gauri J. Kiefer, Philip J. Stella, Katherine Minichiello, David R. Gandara, Roy S. Herbst, Vassiliki A. Papadimitrakopoulou
Summary: The S1400A study aimed to evaluate the activity of durvalumab in patients with squamous cell carcinoma of lung. Results showed a response rate of 14% in PD-L1-positive patients, indicating that the drug has comparable toxicity to others in its class.
CLINICAL LUNG CANCER
(2021)
Article
Oncology
Albrecht Stenzinger, Brian Cuffel, Noman Paracha, Eric Vail, Jesus Garcia-Foncillas, Clifford Goodman, Ulrik Lassen, Gilles Vassal, Sean D. Sullivan
Summary: This article presents a simple metric, cost per correctly identified patient (CCIP), to inform policies on genomic testing strategies. The results show that, in most evaluated cancer types, the cost to correctly identify patients using NGS is lower than sequential single-gene testing (SGT).
Article
Biochemistry & Molecular Biology
Shruti Magesh, Pranava Gande, Rishabh Yalamarty, Daniel John, Jaideep Chakladar, Wei Tse Li, Weg M. Ongkeko
Summary: In this study, the expression of transfer RNA-derived fragments (tRFs) was analyzed in lung squamous cell carcinoma (LUSC) to investigate their association with etiology and clinical outcomes. The results showed significant differences in tRF expression among different subtypes of LUSC, and these tRFs were correlated with patient survival. Particularly, tRF expression in smoking-induced LUSC and non-smoking-induced LUSC was associated with cancer stage and treatment efficacy. These findings may contribute to the development of improved diagnostic and therapeutic approaches for LUSC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shankha Satpathy, Karsten Krug, Pierre M. Jean Beltran, Sara R. Savage, Francesca Petralia, Chandan Kumar-Sinha, Yongchao Dou, Boris Reva, M. Harry Kane, Shayan C. Avanessian, Suhas V. Vasaikar, Azra Krek, Jonathan T. Lei, Eric J. Jaehnig, Tatiana Omelchenko, Yifat Geffen, Erik J. Bergstrom, Vasileios Stathias, Karen E. Christianson, David Heiman, Marcin P. Cieslik, Song Cao, Xiaoyu Song, Jiayi Ji, Wenke Liu, Kai Li, Bo Wen, Yize Li, Zeynep H. Gumus, Myvizhi Esai Selvan, Rama Soundararajan, Tanvi H. Visal, Maria G. Raso, Edwin Roger Parra, Ozgun Babur, Pankaj Vats, Shankara Anand, Tobias Schraink, MacIntosh Cornwell, Fernanda Martins Rodrigues, Houxiang Zhu, Chia-Kuei Mo, Yuping Zhang, Felipe da Veiga Leprevost, Chen Huang, Arul M. Chinnaiyan, Matthew A. Wyczalkowski, Gilbert S. Omenn, Chelsea J. Newton, Stephan Schurer, Kelly Ruggles, David Fenyo, Scott D. Jewell, Mathangi Thiagarajan, Mehdi Mesri, Henry Rodriguez, Sendurai A. Mani, Namrata D. Udeshi, Gad Getz, James Suh, Qing Kay Li, Galen Hostetter, Paul K. Paik, Saravana M. Dhanasekaran, Ramaswamy Govindan, Li Ding, Ana Robles, Karl R. Clauser, Alexey Nesvizhskii, Pei Wang, Steven A. Carr, Bing Zhang, D. R. Mani, Michael A. Gillette
Summary: The proteogenomic analysis of LSCC reveals a deeper understanding of its biology and potential therapeutic directions. New therapeutic targets and rationale for further exploration have been identified, along with support for complex regulation of metabolic pathways and immune-related research directions. Furthermore, insights from triangulation with other cancers highlight unique and shared vulnerabilities, guiding future research into LSCC biology and treatment.
Article
Oncology
Yifei Fang, Yunhui Qu, Longtao Ji, Hao Sun, Jiaqi Li, Yutong Zhao, Feifei Liang, Zhi Wang, Jiao Su, Jingjing Liu, Liping Dai, Songyun Ouyang
Summary: The study reveals an association between hypomethylation of the FUT7 gene and lung cancer, especially for LUSC. This provides novel support for the use of blood-based methylation markers in assessing lung cancer risk.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Jian He, Nianxiang Qiu, Xianchao Zhou, Mei Meng, Zixue Liu, Jingquan Li, Shiyu Du, Zhiqiang Sun, Hui Wang
Summary: By studying the mRNA and protein levels of SIRT2 in different cancers, we found that SIRT2 affects the prognosis of various types of cancers, especially LUAD. Further research suggested that SIRT2 mRNA levels are positively correlated with the infiltrating status of multiple immunocytes in LUAD, and it may contribute to the recruitment of certain immune cells. Triacetylresveratrol showed the most potent agonist efficiency to SIRT2, making it a potential immunomodulator for LUAD. Therefore, SIRT2 could be a promising biomarker for prognosis prediction in LUAD patients, and triacetylresveratrol could be used in combination therapies with anti-PD-1 immunotherapy.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhenyi Niu, Runsen Jin, Yan Zhang, Hecheng Li
Summary: Lung cancer is a major cause of cancer-related death worldwide, with patients with lung squamous cell carcinoma (LSCC) not benefiting from targeted therapies. Immunotherapy has improved outcomes in cancer patients, but its clinical application in LSCC is hindered by low response rates and adverse events. Understanding the mechanisms of LSCC pathogenesis and the connections between signaling pathways is important for developing more effective treatments. This review discusses classical signaling pathways, potential therapeutic targets, epigenetic and immune checkpoint therapies, and combination strategies for LSCC.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Oncology
Jie Mei, Yun Cai, Ofek Mussafi, Mingfeng Zheng, Yongrui Xu, Ruo Chen, Guanyu Jiang, Wenjun Mao, Wei Xia, Yuan Wan
Summary: Non-small cell lung cancer (NSCLC) is a heterogeneous disease with different molecular features. A new subtype, LASC, was identified through clustering analysis of transcriptome data and showed the highest immune escaping phenotype among all NSCLC subtypes. FOLR1 was identified as a biomarker for distinguishing LASC and validated using internal cohorts.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Review
Chemistry, Medicinal
Archana Sonkar, Pranesh Kumar, Anurag Gautam, Biswanath Maity, Sudipta Saha
Summary: This review summarizes the current understanding of different signaling pathways in lung cancer, describing the main molecular pathways and changes involved in the development, progression, and cellular breakdown of the disease. It also focuses on targeted therapies for lung cancer.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Fumihiko Kinoshita, Yuka Oku, Shinkichi Takamori, Takatoshi Fujishita, Ryo Toyozawa, Kensaku Ito, Fumihiro Shoji, Tatsuro Okamoto
Summary: The efficacy and safety of N + GC in the second-line or later treatment of LSCC patients have been proven. However, the management of adverse events is essential.
INVESTIGATIONAL NEW DRUGS
(2023)
Article
Medicine, General & Internal
Quewang Liu, Yueying Wang, Meiyu Duan, Yusi Fan, Xingyuan Pan, Shuai Liu, Qiong Yu, Lan Huang, Fengfeng Zhou
Summary: The study found that sex-specific models outperformed sex-independent models in detecting early-stage lung cancers, and Venn plots indicated that females and males shared only a few transcriptomic biomarkers of early-stage lung cancers. Therefore, sex information plays an important role in optimizing disease diagnosis models.
Article
Medicine, General & Internal
Saurabh Singh, Manju Mathew, Thomy Mertzanidou, Shipra Suman, Joey Clemente, Adam Retter, Marianthi-Vasiliki Papoutsaki, Lorna Smith, Francesco Grussu, Veeru Kasivisvanathan, Alistair Grey, Eoin Dinneen, Greg Shaw, Martyn Carter, Dominic Patel, Caroline M. Moore, David Atkinson, Eleftheria Panagiotaki, Aiman Haider, Alex Freeman, Daniel Alexander, Shonit Punwani
Summary: This study aims to clinically validate two advanced MRI techniques in order to predict biopsy results and avoid unnecessary biopsies for men suspected of prostate cancer. The study will use histological analysis to validate the effectiveness of these MRI techniques and determine the true positive rate and false positive rate through experimental results. This will provide a foundation for developing more accurate methods for diagnosing prostate cancer.
Article
Oncology
Scott N. Gettinger, Mary W. Redman, Lyudmila Bazhenova, Fred R. Hirsch, Philip C. Mack, Lawrence H. Schwartz, Jeffrey D. Bradley, Thomas E. Stinchcombe, Natasha B. Leighl, Suresh S. Ramalingam, Susan S. Tavernier, Hui Yu, Joseph M. Unger, Katherine Minichiello, Louise Highleyman, Vassiliki A. Papadimitrakopoulou, Karen Kelly, David R. Gandara, Roy S. Herbst
Summary: Overall, in patients with advanced, pretreated, immune checkpoint inhibitor-naive SqNSCLC, the addition of ipilimumab to nivolumab did not lead to improved outcomes. There was no significant difference in overall survival and progression-free survival between the nivolumab/ipilimumab and nivolumab alone groups. Adverse events were more common in the nivolumab/ipilimumab group, but discontinuation rates were similar between the two groups.
Article
Oncology
Scott N. Gettinger, Mary W. Redman, Lyudmila Bazhenova, Fred R. Hirsch, Philip C. Mack, Lawrence H. Schwartz, Jeffrey D. Bradley, Thomas E. Stinchcombe, Natasha B. Leighl, Suresh S. Ramalingam, Susan S. Tavernier, Hui Yu, Joseph M. Unger, Katherine Minichiello, Louise Highleyman, Vassiliki A. Papadimitrakopoulou, Karen Kelly, David R. Gandara, Roy S. Herbst
Summary: In this study, it was found that adding ipilimumab to nivolumab did not improve outcomes in patients with advanced, pretreated, immune checkpoint inhibitor-naive squamous non-small cell lung cancer.